Shanghai Ninth People's Hospital

Large language models for patient-centred evidence generation and use

Preprint. Not peer reviewed. For people with multimorbidity, disease-specific evidence can leave practical questions unanswered. We propose an evidence operating system (Evidence OS) that follows patient priorities through evidence synthesis, research and the return of findings t...

Integrated postmortem brain transcriptomics identifies a five-gene Alzheimer’s disease-associated signature with a reproducible whole-blood CEBPB correlate

Transcriptomic profiling provides a systems-level view of Alzheimer’s disease (AD), capturing coordinated neuronal, glial, vascular, and immune-related changes. Yet the same breadth that makes transcriptomics informative also complicates interpretation because technical heterogen...

Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression

Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have y...

Artificial intelligence in radiographic quantification and severity assessment of peri‐implant marginal bone loss: A systematic review

ABSTRACT Purpose To critically assess artificial intelligence (AI)‐based radiographic models for quantitative measurement, localization/detection, segmentation/keypoints, diagnostic classification, and severity or morphology assessment of peri‐implant marginal bone loss (MBL) and...

Population Pharmacokinetics of Topical Timolol Maleate Gel in Healthy Volunteers and Infants With Superficial Infantile Hemangioma

Although timolol ophthalmic solutions or hospital-compounded formulations have been used off-label for the treatment of superficial infantile hemangioma (IH), no topical timolol formulation has been developed specifically for this indication. This study was the first to develop a...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Large language models for patient-centred evidence generation and use

Author preprint. Not peer reviewed. For patients with several health conditions, evidence for one disease may leave important questions about care unanswered. Large language models (LLMs) offer ways to help formulate these questions, examine the literature, and prepare requests f...

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...

An iPAS-optimized phage cocktail delivered by a skin-derived ECM hydrogel for antimicrobial-regenerative treatment of seawater immersion wounds infected with MDR E. coli

Seawater immersion (SWI) wounds are prone to multidrug-resistant (MDR) bacterial infections and impaired tissue repair, yet dual-function wound dressings that combine robust antibacterial activity with proregenerative capacity remain scarce. Through shotgun metagenomic sequencing...

Clinical characteristics and immunodiagnostic efficacy validation of cervical lymph node tuberculosis: a retrospective study based on clinically confirmed cases

This study aimed to investigate the clinical characteristics and diagnostic performance of immunological tests in cervical tuberculous lymphadenitis (CTBL) across different age cohorts, providing reference for early clinical identification and diagnosis. A retrospective cohort st...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

ARID1A Mediates ROS-Induced Osteoclast Activation in TMJ Osteoarthritis

Excessive osteoclast activation drives rapid subchondral bone destruction, serving as a critical early-stage event precipitating temporomandibular joint osteoarthritis (TMJ-OA). Although epigenetic remodeling is widely recognized as an important interface between pathological env...

Risk Scrutiny and Future Opportunities of Robot-Assisted Implant Surgery: A Narrative Review

Introduction and aims Robot-assisted implant surgery (RAIS) signifies a major advancement in computer-guided implant technology. In comparison to traditional hand-guided placement, RAIS enhances the precision and standardization of implant positioning. However, the increased tech...

20-year experience of biomet stock alloplastic temporomandibular joint replacement in Chinese patients after technical modifications: a single-center retrospective study.

OBJECTIVES: To evaluate the clinical and radiographic outcomes of the Biomet stock alloplastic temporomandibular joint replacement (ATJR) after seven progressive surgical modifications in Chinese patients at a single center. MATERIALS AND METHODS: Patients who underwent ATJR from...

Magnesium-containing hierarchical porous scaffold incorporating alpha-lipoic acid ethosomes for neurovascularized bone regeneration under diabetic conditions

Diabetes mellitus severely impairs bone regeneration due to a compromised neurovascular microenvironment. Current therapeutic approaches frequently overlook the need to support neurovascular repair under hyperglycemic conditions, leading to suboptimal bone defect healing. To addr...

Morphology‐Engineered Bismuth‐Porphyrin MOFs for H 2 S Scavenging Mediated Synergistic Photo‐Immunotherapy Against MRSA‐Infected Diabetic Wounds

ABSTRACT Diabetic wounds infected with methicillin‐resistant Staphylococcus aureus (MRSA) pose a significant challenge to clinical healing. Proliferating MRSA not only invades neutrophils to induce immunosuppression but also produces hydrogen sulfide (H 2 S) and forms biofilms to...

Parturition attenuates endothelial senescence to resist nitrosative stress-induced heart failure with preserved ejection fraction in mice

Abstract Background Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of heart failure patients and is biased toward elderly females. Nitrosative stress-induced HFpEF animal studies fail to phenocopy this sex bias and the underlying pathological mechanisms r...

Cell-inspired dual-tandem catalytic nanoreactors drive targeted hearing protection

Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen specie...

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor demarcation are critical for effective treatment. Herein, we developed a strategic platform that combines a novel ultrasensitive magnetic...

Home enteral nutrition management in postoperative oral cancer patients: an evidence summary

Abstract Background This study aimed to establish a standardized management system for home enteral nutrition (HEN) for patients with postoperative oral cancer and provide scientific guidance for clinical professionals by systematically searching relevant literature and summarizi...