Shanghai First People's Hospital

Rapid versus slow puncture in endoscopic ultrasound-guided liver biopsy: a multicenter randomized crossover trial

Abstract Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapi...

GNAZ suppresses lung adenocarcinoma progression through HUWE1-mediated KIF11 ubiquitination and modulates the response to osimertinib

Osimertinib is a standard targeted therapy for EGFR-mutant lung adenocarcinoma (LUAD), yet substantial variation in treatment response remains a clinical problem. Here, we investigated the role of GNAZ, a heterotrimeric G-protein α-subunit that remains poorly characterized in lun...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Different concentrations of atropine in children with high myopia: a 2-year multicenter double-blind, randomized controlled trial

High myopia in children risks irreversible visual impairment, yet optimal interventions remain debated. This multicenter double-blind, randomized-controlled trial aims to evaluate the effect and safety of different atropine eyedrops for myopia control in children with high myopia...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Myocardial tissue characteristics assessed by multiparametric CMR in hyperthyroid patients with suspected cardiac involvement

Abstract Background Hyperthyroidism is reportedly associated with increased cardiovascular risk and heart failure. However, a definite association between hyperthyroidism and cardiomyopathy has not been reported. This study aimed to analyze alterations in myocardial tissue charac...

PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies

PRDM16 is a PR domain-containing epigenetic regulator with intrinsic histone methyltransferase activity and scaffolding interactions with corepressor complexes such as CtBP1/2. Beyond its well-established roles in adipose biology, emerging evidence positions PRDM16 as a central n...

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial

Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myop...

Endothelial function in relation to low-level chronic residential air pollution in a general population: a cohort study

Background Given the recently updated clean-air targets, this population study assessed endothelial function at low exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and ≤2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC).Methods In 453 Flemi...

Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics

Abstract Cerebrospinal fluid contributes to homeostasis in the central nervous system, but how its dynamics are altered in glioblastoma is unclear. We find that glioblastoma drives leptomeningeal perivascular fibrosis that is associated with impaired fluid transport and clearance...

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor demarcation are critical for effective treatment. Herein, we developed a strategic platform that combines a novel ultrasensitive magnetic...

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...

Macrophage-derived IL-1β drives endothelial-mesenchymal transition in diabetes mellitus erectile dysfunction

Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...