Shahid Beheshti University of Medical Sciences

Extensive head and neck necrotizing fasciitis induced by mandibular canine tooth infection in an uncontrolled diabetic patient: a case report

Abstract Background Head and neck necrotizing fasciitis is a rare, progressive soft tissue infection that usually originates from odontogenic sources. Systemic diseases, including immunosuppression and diabetes mellitus, can complicate patient management. Case presentation We rep...

Functional resonance analysis method and monte carlo simulation: evaluating performance variability in a socio-technical direct reduction iron plant

Direct Reduction Iron (DRI) units are complex socio-technical systems where traditional failure-centric risk models often fail to capture emergent behaviors. This study aims to develop an integrated resilience-based framework to quantify performance variability and identify criti...

Trends (2014–2023), forecasting (2024–2026), and risk factors of drug-resistant tuberculosis in Iran: a negative binomial time-series generalized linear model

Drug-resistant tuberculosis (DR-TB) remains a major challenge for achieving the End TB Strategy. This study aimed to examine temporal trends of DR-TB in Iran, identify demographic and clinical risk factors, and forecast future incidence to support public health planning. A time s...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Hematologic Indices of Hemoglobin D Co-Inheritance with α and β Thalassemia: A Comparative Study of 202 Patients

To characterize the hematologic effects of hemoglobin D (HbD) alone and in the presence of co-inherited α- or β-thalassemia, and to quantify associations with anemia, microcytosis, and hypochromia relative to normal-CBC controls. This retrospective comparative study included 202...

Quantitative Susceptibility Mapping‐Based Characterization of Lesion Heterogeneity in Multiple Sclerosis

ABSTRACT Background Quantitative susceptibility mapping (QSM) characterizes multiple sclerosis (MS) lesions through susceptibility changes related to iron and myelin. However, the prevalence, regional distribution, and relationship of QSM‐defined lesion subtypes with choroid plex...

Ecological analysis of Cutaneous leishmaniasis incidence and climatic variability in Kashan and Aran - Bidgol, Iran (2014–2024)

Cutaneous leishmaniasis (CL) is a major neglected tropical disease whose transmission is strongly influenced by climatic and environmental conditions. This study investigated the temporal associations between climatic variables and CL incidence in Kashan and Aran and Bidgol count...

Understanding responses to domestic violence and abuse among older adults: a systematic review and meta-synthesis of stakeholder perspectives

Domestic violence and abuse (DVA) among older adults is an increasingly recognized public health and human rights concern with significant physical, psychological, and social consequences. This systematic review and meta-synthesis aimed to synthesize qualitative evidence on respo...

Pathways to empowerment of adolescent mothers: a policy-oriented approach for improving postpartum self-efficacy and health service access within Iran’s health system

Adolescent motherhood is a complex public health and social challenge, particularly in low- and middle-income countries where cultural norms and policy frameworks intersect. Teen mothers often enter parenthood without adequate emotional readiness, social support, or access to you...

Resilient surgical instrument reprocessing during healthcare disasters and outbreaks: a systematic review of barriers, preparedness gaps and policy strategies

Surgical instrument reprocessing is essential for infection prevention and continuity of surgical care. However, evidence on barriers and adaptive strategies for maintaining reprocessing capacity during healthcare disruptions remains fragmented. This systematic review synthesized...

Altered causality perception in Parkinson’s disease

Causality perception allows observers to infer causal relationships from dynamic visual events. A classic example is Michotte’s launching effect, in which one moving object contacts a stationary object and stops as the second object begins to move, creating the perceptual impress...

Fabrication and evaluation of a polymeric muco-adhesive film with local and controlled release of phenytoin: an in vitro investigation

Phenytoin has long been used to accelerate wound healing. The aim of this study is to design, fabricate, and evaluate some properties of a polymeric mucoadhesive film with slow release of phenytoin. In this in vitro study, polymers such as Hydroxypropyl Methylcellulose, Sodium ca...

Pulmonary hydatid cyst presenting with altered consciousness in a 19-year-old Afghan migrant: a case report and review of the literature

Hydatid disease is a parasitic infection caused by the larval stage of the tapeworm Echinococcus granulosus. Clinical manifestations vary based location and size of the cyst. While pulmonary hydatid cysts are well-documented, neurological presentations such as altered consciousne...

The effect of an in-person mindfulness program on compassion in nursing care among undergraduate nursing students

Abstract Background and Objective: Compassion is a central value in nursing, involving humanity, empathy, love, and wisdom. As nursing is closely tied to care, students’ clinical experiences shape their compassionate skills. Mindfulness improves self-awareness and may foster comp...

Effectiveness of AI-enhanced virtual patients in clinical reasoning training of healthcare professionals and students: a systematic review

Clinical reasoning is a core competency for healthcare students and professionals. However, current educational approaches may not adequately prepare learners for its complexity in practice. Virtual patients (VPs) provide a structured strategy for clinical reasoning education, an...

Circular RNAs as regulators of epithelial‑mesenchymal transition in gliomas from molecular mechanisms to clinical applications

Epithelial–mesenchymal transition (EMT) is a fundamental biological process that drives glioma invasion, therapeutic resistance, and malignant progression. Recent evidence highlights circular RNAs (circRNAs) as pivotal post-transcriptional regulators that orchestrate EMT through...

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

Development, implementation, and evaluation of web-based decision support application for developmental care of preterm infants: a multi-phase study

Developmental care is a critical component of high-quality neonatal services for preterm infants. However, variability in gestational age assessment and inconsistencies in translating assessment findings into care practices can compromise developmental outcomes. Digital clinical...

The effect of reduced carbohydrate diet on cardiometabolic risk factors and gut microbiota in children and adolescents with obesity: a randomized controlled trial

Abstract Objective To compare the effects of a reduced-carbohydrate diet (RCD) with a standard diet (STD) on cardiometabolic risk factors and gut microbiota composition in children and adolescents with obesity. Methods In this randomized controlled trial, 84 children and adolesce...

Incidence and clinical characteristics of amyotrophic lateral sclerosis during the post-COVID-19 Period: a population-based study from Isfahan, Iran

AIMS: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Understanding the underlying causes would help further studies on the pathogenesis and treatments. Recent interest has emerged in evaluating whether the COVID-19 pandemic and vaccination have a...