Shahid Beheshti University of Medical Sciences

Advanced Pulmonary Drug Delivery Systems: A Narrative Review

Pulmonary drug delivery systems have gained increasing attention as an effective strategy for the treatment of both respiratory and systemic diseases by enabling targeted, noninvasive, and efficient drug administration through the lungs, with advantages including rapid onset of a...

Short‐Term Clinical Comparison of Scapular Stabilization With and Without Added Kinetic‐Chain Exercises on Pain, Scapular Kinematics, and Upper‐Extremity Function in Overhead Athletes With Subacromial Pain Syndrome: A Randomized Controlled Trial

BACKGROUND AND PURPOSE: Scapular stabilization exercises are commonly used in the rehabilitation of athletes with subacromial pain syndrome (SAPS) and scapular dyskinesis. Whether supplementing scapular stabilization with kinetic-chain exercises provides greater short-term benefi...

Coated or chewable Aspirin and a hybrid air pollution mitigation strategy in patients with atherosclerotic disease: Rationale and Design of the COATED-AIR Randomized Trial.

BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...

Artificial intelligence in radiographic quantification and severity assessment of peri‐implant marginal bone loss: A systematic review

ABSTRACT Purpose To critically assess artificial intelligence (AI)‐based radiographic models for quantitative measurement, localization/detection, segmentation/keypoints, diagnostic classification, and severity or morphology assessment of peri‐implant marginal bone loss (MBL) and...

Low serum levels of C1q/TNF-related protein-14 (CTRP14) in newly diagnosed type 2 diabetes patients

To measure serum C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) levels in newly diagnosed, treatment-naïve men with type 2 diabetes mellitus (T2DM) and healthy controls, and to investigate their associations with metabolic parameters, the presence of T2DM and insulin re...

The pathway from feeling of emptiness to suicidal ideation: Examining the mediating roles of psychological pain and hopelessness in clinical and non‐clinical populations

Abstract Objective The current study aimed to examine the relationship between the feeling of emptiness and suicidal ideation, and the mediating roles of psychological pain and hopelessness, in Iranian clinical and non‐clinical populations within the framework of the Three‐Step T...

Genetically engineered dendritic cells in cancer immunotherapy: from immune reprogramming strategies to emerging CAR-DC platforms

Genetic engineering can enhance dendritic cell (DC) migration, antigen presentation, co-stimulation, cytokine production, survival, and resistance to tumor-mediated suppression. This review examines established engineering strategies and emerging chimeric antigen receptor-enginee...

Altered expression of ZAP70 and lnc-FAHD2B-3 in colorectal polyps: an exploratory molecular study

Colorectal cancer (CRC) is a major global health concern that often develops from precursor lesions, particularly adenomatous colorectal polyps. However, the molecular alterations associated with early colorectal neoplasia remain incompletely understood. ZAP70, a signaling molecu...

Ultra-processed food consumption (NOVA index) and the odds of diabetic nephropathy in women: a case-control study

diabetic nephropathy (DN) is a major complication of diabetes mellitus associated with increased morbidity and mortality. Dietary factors, particularly unhealthy food consumption, may contribute to kidney dysfunction. This study aimed to investigate the association between the NO...

Resident and faculty experiences of an integrated anatomy curriculum in general and orthopedic surgery: a qualitative study of specialty alignment and psychological safety

Clinical anatomy is widely regarded as a precondition of safe operative practice, yet formal instruction usually ends in the preclinical years, leaving a prolonged interval before residents assume operative responsibility. An integrated clinical anatomy curriculum shared by Gener...

Global prevalence of identified causative antigens and geographic variation in antigen distribution among patients with hypersensitivity pneumonitis: protocol for a systematic review and meta-analysis

Abstract Background Hypersensitivity pneumonitis (HP) is an immune-mediated interstitial lung disease triggered by inhalation of a causative antigen. Antigen identification is central to management because antigen removal is the cornerstone of treatment and is independently assoc...

Association between dietary phytochemical index and pancreatic steatosis in patients with common bile duct stones

The dietary phytochemical index (DPI) may protect against pancreatic steatosis (PS), but evidence is limited. This study examined the association between DPI and PS risk. This case-control study included 278 patients with common bile duct stones at Taleghani Hospital, Tehran, bet...

Association of dietary phytochemical index (DPI) with psychological disorders and serum levels of adropin and brain-derived neurotrophic factor in Iranian adults

Considering the contradictory findings of earlier studies in terms of association between dietary phytochemical index (DPI) and psychological disorders, this study evaluated relationship between DPI and psychological disorders (as primary outcome), regarding their association wit...

Cross-cultural adaptation and validation of the Persian version of the International Hip Outcome Tool-12 (iHOT-12-Pr) in young to middle-aged active adults with hip disorders

To our knowledge, no validated Persian version of the 12-item International Hip Outcome Tool (iHOT-12) has been published for assessing active adults with hip disorders. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Persian iHOT-...

Incremental Prognostic Value of CT Indices Derived from Midline Shift and Hematoma Thickness in Acute Subdural Hematoma

Background: In acute subdural hematoma (ASDH), early risk stratification relies heavily on hematoma thickness (HT) and midline shift (MLS). Composite indices derived from these measures have been proposed to better characterize mass effect, but their incremental prognostic value...

Global prevalence of colistin resistance, mcr gene variants, and sequence types in Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Abstract Background Due to the increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria, colistin has become an important therapeutic option. However, the rapid emergence of resistance to this antimicrobial agent, mediated by mechanisms such...

Association between preoperative hypoalbuminemia and postoperative complications in spinal fusion surgery: an approach- and spinal level-stratified meta-analysis

While hypoalbuminemia is recognized as a risk factor for adverse postoperative outcomes in various surgeries, its specific impact on spinal fusion outcomes has not been systematically synthesized. This meta-analysis aimed to evaluate the association between preoperative hypoalbum...

In vitro oocyte maturation is associated with altered OCT4 promoter methylation, DNMT expression, and early embryonic development in transgenic mouse embryos

Objective: In vitro oocyte maturation (IVM) is widely used in assisted reproductive technologies; however, its potential effects on epigenetic regulation and embryonic development remain incompletely understood. In this study, we compared the developmental competence and epigenet...

The association between perceived social support and glycemic status transitions: a 3-year longitudinal study of Iranian adults

This three-year longitudinal study investigates the association of Perceived Social Support and its subscales with changes in blood-glucose status among Iranian adults. In a three-year cohort of 1,458 Iranian adults, perceived social support was measured with the 12-item Iranian...

Psychological risk factors for non-suicidal self-injury in sexually traumatized adolescents: a cross-sectional analysis with random forest classification

Non-suicidal self-injury (NSSI) is a significant mental health issue among adolescents, especially those with histories of sexual trauma. This study examined the individual and synergistic roles of posttraumatic stress symptoms (PTSS), depression, anxiety, and sleep quality in pr...