Shahid Beheshti University of Medical Sciences

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

The effect of reduced carbohydrate diet on cardiometabolic risk factors and gut microbiota in children and adolescents with obesity: a randomized controlled trial

Abstract Objective To compare the effects of a reduced-carbohydrate diet (RCD) with a standard diet (STD) on cardiometabolic risk factors and gut microbiota composition in children and adolescents with obesity. Methods In this randomized controlled trial, 84 children and adolesce...

Development, implementation, and evaluation of web-based decision support application for developmental care of preterm infants: a multi-phase study

Developmental care is a critical component of high-quality neonatal services for preterm infants. However, variability in gestational age assessment and inconsistencies in translating assessment findings into care practices can compromise developmental outcomes. Digital clinical...

Tenting screw (tent pole) technique in vertical and horizontal alveolar ridge augmentations: a systematic review and meta-analysis

Abstract Purpose Providing an overview on tenting screws/tent-pole technique for space-maintenance in vertical and horizontal alveolar ridge augmentation. Methods The protocol was registered at PROSPERO (CRD420251178321). PRISMA-2020 guidelines were applied. Medline via PubMed, W...

Incidence and clinical characteristics of amyotrophic lateral sclerosis during the post-COVID-19 Period: a population-based study from Isfahan, Iran

AIMS: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Understanding the underlying causes would help further studies on the pathogenesis and treatments. Recent interest has emerged in evaluating whether the COVID-19 pandemic and vaccination have a...

Non-urgent emergency department utilization in adults: a systematic review of associated factors across diverse health systems

Non-urgent emergency department (ED) visits represent a growing global challenge with significant economic and operational consequences. Despite previous reviews, important gaps remain. No review has included all commonly used terms for non-urgent ED visits, recent evidence has n...

The association between stress hyperglycemia ratio and adverse outcomes in patients with chronic kidney disease: a systematic review and meta-analysis

Chronic kidney disease (CKD) increases risks of cardiovascular events and mortality, so reliable biomarkers are needed to improve risk stratification. Stress hyperglycemia ratio (SHR), which adjusts acute glucose levels for chronic glycemia using glycated hemoglobin, has shown pr...

Plasma p-tau217 as a two-cutoff approach to improve tau-PET screening and trial recruitment in Alzheimer’s disease

Abstract Blood-based biomarkers could broaden access to Alzheimer’s disease diagnostics, but their ability to approximate tau PET, and to address gray-zone results, remains uncertain. We evaluated plasma p-tau217 against tau PET using a harmonized ADNI baseline cohort and an inde...

Comparative effectiveness of cognitive behavioral therapy versus group-based optimism training on psychological outcomes in hemodialysis patients: a randomized controlled trial

Patients undergoing hemodialysis (HD) face significant psychological challenges that affect their well-being. Nevertheless, no comparative investigation has yet examined the efficacy of cognitive-behavioral therapy (CBT) versus group-based optimism training on psychological outco...

Survival and biological and technical complications of veneered zirconia-ceramic versus metal-ceramic restorations: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to critically assess and compare the survival rates and the spectrum of biological and technical complications associated with veneered zirconia-ceramic versus metal-ceramic restorations. By synthesizing evidence from randomized clin...

Hepatic steatosis assessed by transient elastography in patients with significant coronary artery disease: a cross-sectional study

While metabolic dysfunction-associated steatotic liver disease (MASLD) and coronary artery disease (CAD) share metabolic risk factors, it remains unclear whether the anatomical severity of CAD predicts the severity of hepatic steatosis or fibrosis. This study aimed to estimate MA...

Effect of a free sugar-restricted diet on anthropometric parameters, lipid profile, and glycemic control in women with polycystic ovary syndrome: a randomized controlled trial

Abstract Background High-sugar diets rich in fructose and other simple sugars are associated with increased lipogenesis and insulin resistance, potentially increasing the risk of metabolic syndrome, a condition closely linked with polycystic ovary syndrome (PCOS). This study aime...

Effectiveness of tele-occupational performance coaching in improving occupational performance and executive function in children with attention deficit hyperactivity disorder: a pilot randomised controlled trial

Background/Aims Occupational performance coaching is a family-centred intervention to enhance occupational performance in children. The remote variant, tele-occupational performance coaching, has become a viable option, especially for children with attention deficit hyperactivity...

Evaluation of Iraq’s national plan for hepatitis B control: identifying gaps and strategies for improvement

Hepatitis B virus (HBV) remains a significant public health challenge in Iraq, necessitating a comprehensive evaluation of the national hepatitis B control plan. This study aimed to assess the epidemiological trends of HBV in Iraq from 2015 to 2022 and evaluate the implementation...