Shahid Beheshti University of Medical Sciences

Adult intestinal malrotation: A rare incidental finding in trauma imaging

Intestinal malrotation is a congenital anomaly resulting from abnormal rotation and fixation of the midgut during embryonic development. It is typically diagnosed in infancy, and its detection in adults—particularly in asymptomatic individuals—is rare. In adults, clinical present...

A step forward to exploring the inhibitory effects of crude honey bee venom (Apis mellifera) and its derived phospholipase A2 (bvPLA2) against Leishmania major in vitro

Leishmaniasis is a widespread parasitic disease with cutaneous, mucocutaneous, and visceral forms. Despite longstanding recognition, effective treatment remains a challenge due to limitations of current chemotherapies, including toxicity and resistance. Natural toxins, particular...

Dietary acid load is associated with quality of life in overweight and obese adult in Iranian women: a cross sectional study

Epidemiologic investigations have shown that dietary acid load (DAL) is associated with some limited quality of life (QoL) markers; however, according to the documents available so far, the association of this dietary pattern with QoL among overweight and obese women is not clear...

Targeting ferroptosis in cancer: molecular mechanisms and emerging therapeutic strategies

Ferroptosis, an iron-dependent form of regulated cell death characterized by the lethal accumulation of lipid peroxides, has emerged as a pivotal pathway in cancer biology and a promising therapeutic target. This review synthesizes the core molecular machinery governing ferroptos...

Early life stress caused glucose homeostasis impairment and anxiety-like behavior along with oxidative stress in adolescent male rat offspring: Protective effect of saffron extract

Early life stress (ELS) significantly contributes to metabolic and psychological disorders by triggering oxidative stress and disrupting the hypothalamic–pituitary–adrenal (HPA) axis. This research examined ELS effects on redox status, along with anxiety-like behavior, in adolesc...

Comparative analysis of outcomes of surface ablation for myopic astigmatism in patients after PKP and DALK

Purpose To compare the outcomes of surface ablation (SA) in patients who have previously undergone Deep Anterior Lamellar Keratoplasty (DALK) and Penetrating keratoplasty (PKP). Methods This retrospective study evaluated the outcomes of SA in Keratoconus (KCN) patients who had pr...

Presenting a new scoring system based on clinical and inflammatory factors to classify the severity of bipolar disorder

Background Various clinical and laboratory factors are related to the severity of bipolar disorder, but there is no global agreement for the role of these factors.Methods Forty patients with the definitive diagnosis of bipolar disorder were included in this prospective study. The...

Effects of virtual reality, feedback-based virtual reality, and interactive lecture–based ESI triage training on triage accuracy and nursing students’ satisfaction: a quasi-experimental study

Accurate triage is essential for efficient emergency care; however, little is known about the comparative effectiveness of interactive lecture (IL), virtual reality (VR), and feedback-based virtual reality (FVR) for Emergency Severity Index (ESI) triage training among nursing stu...

Preliminary molecular characterization of Blastocystis sp. subtypes among IBS patients and non-IBS individuals in Hamadan Province, western Iran

Blastocystis sp. is a common protozoan parasite in humans and has frequently been implicated in gastrointestinal disorders such as irritable bowel syndrome (IBS). This study aimed to preliminarily characterize and descriptively compare the distribution of Blastocystis subtypes am...

Familial nemaline myopathy and multiple sclerosis: a case report exploring a novel co-occurrence with familial clustering

Nemaline myopathy (NM) and multiple sclerosis (MS) are distinct disorders with different genetic or epigenetic characteristics, and their co-occurrence has not been priorly documented. We report a 40-year-old male with a notable familial history of both NM and MS who was diagnose...

Frequency of positive margins and predictors in breast-conserving surgery in developing countries

Achieving negative surgical margins in breast-conserving surgery (BCS) is crucial due to the risks linked to positive margins, such as the need for reoperation and elevated local recurrence rates. Limited data exist about positive margins after BCS in developing countries, includ...

Cell-free supernatant of Limosilactobacillus reuteri enhances 5-fluorouracil-induced apoptosis in SW-480 colorectal cancer cells: an in vitro study

5-fluorouracil (5-Fu) is a main treatment for colorectal cancer (CRC) but shows limited efficacy and serious side effects, creating a need for novel adjunct therapies. Recent evidence suggests Limosilactobacillus reuteri derivatives may have anticancer properties. Accordingly, th...

Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross‐sectional study

Abstract Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our know...

Circadian Clock Crosswalk Between Chronic Disease and Antitumor Response

Circadian disruption is increasingly recognized as a contributing factor in both chronic disease and impaired antitumor immunity; however, these two fields have largely evolved independently. We conducted a Scale for the Assessment of Narrative Review Articles-guided narrative re...

Association of total and source-specific dietary nitrate and nitrite with subclinical atherosclerosis in young adults

Atherosclerosis, a chronic process originating in young adulthood and progressing silently to clinical cardiovascular disease, highlights the need to identify modifiable nutritional exposures. Epidemiological evidence regarding their association with subclinical atherosclerosis i...

Artificial intelligence and machine learning applications in Behçet’s disease: a scoping review protocol

Abstract Background Behçet's disease (BD) is a chronic multisystem vasculitis of unknown aetiology with a characteristic geographic distribution along the historic Silk Road, with highest prevalence in Turkey, Iran, and surrounding regions. Diagnosis remains clinical and often de...

Machine learning-assisted design of a novel crocin-loaded poloxamer 407/hyaluronic acid in situ forming hydrogel for endometriosis treatment: in vitro characterization and in vivo efficacy evaluation

Our study focused on fabricating and characterizing a crocin in situ forming hydrogel for endometriosis treatment. An artificial neural network (ANN)-based machine learning (ML) approach was employed to determine the effects of poloxamer 407 (P407) and hyaluronic acid (HA) concen...

Neuroprotective Effects of Nanocurcumin in Spinal Cord Injury: Modulation of Inflammatory and Inflammasome-Associated Signaling in an Integrated In Vivo , In Silico , and Machine-Learning Study

Spinal cord injury (SCI) triggers secondary neuroinflammatory and inflammasome-associated responses that contribute to tissue damage and functional impairment. This study evaluated nanocurcumin in experimental SCI using integrated experimental, computational, and exploratory mach...

Association between dietary fatty acids and all‐cause mortality in patients with cirrhosis: A cohort study

Abstract Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis‐related death. This study investigated associations between total fat intake, specific dietary fatty acid s...

Advanced Pulmonary Drug Delivery Systems: A Narrative Review

Pulmonary drug delivery systems have gained increasing attention as an effective strategy for the treatment of both respiratory and systemic diseases by enabling targeted, noninvasive, and efficient drug administration through the lungs, with advantages including rapid onset of a...