Semmelweis University

Transfusion practices in intensive care units: a Hungarian nationwide survey

Abstract Physiological transfusion triggers may support red blood cell transfusion decisions in critically ill patients; however, their use in routine clinical practice remains poorly characterized. We conducted a nationwide questionnaire-based survey to assess transfusion practi...

Robustness in sparse artificial neural networks trained with adaptive topology

We investigate the robustness of sparse artificial neural networks trained with adaptive topology. We focus on a simple yet effective architecture consisting of three sparse layers with 99% sparsity followed by a dense layer, applied to image classification tasks such as MNIST an...

Artificial Intelligence in Endometriosis Management: A Guideline-Concordance Study

Objective: This study aimed to evaluate how closely artificial intelligence (AI)- generated clinical recommendations correspond with established international guidelines for endometriosis management, using structured clinical scenarios.Methods: This study assessed the consistency...

Beyond Access and Awareness: The Role of Patient Experience and Physician Communication in Cervical Cancer Screening Participation in Hungary

Background/Objectives: To evaluate cervical cancer screening participation among women in Hungary and to identify motivators, barriers, experiences, and social factors associated with screening attendance. Methods: A cross-sectional survey with nationwide recruitment was conducte...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Tumor border delineation in basal cell carcinoma using Fourier analysis

Basal cell carcinoma (BCC) is the most common malignancy in Caucasians. Surgical excision is the gold standard for treating BCC; however, poorly defined borders often challenge complete removal. Therefore, there is a need for efficient imaging techniques to enable visual and quan...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Preparation and Characterization of Fenofibric Acid-Loaded Electrospun Fibrous Mats

Fenofibric acid-loaded microfibrous mats were produced by electrospinning using polyvinylpyrrolidone (PVP) as a carrier polymer. Fenofibric acid, obtained through alkaline hydrolysis of fenofibrate, was incorporated into PVP solutions and processed under optimized electrospinning...

Motivational drive influences motor and cerebellar alterations in the triple transgenic Alzheimer’s disease model

Abstract Alzheimer’s disease (AD) is accompanied by early motor alterations, yet the contribution of motivational state and testing history to these changes remains poorly understood. We examined locomotor, fine-motor, and molecular profiles in 6–8-month-old male 3xTg-AD mice acr...

The Gut Microbiome as a Mechanistic Link Between the Planetary Health Diet and Healthy Aging

Population aging, the rising burden of chronic non-communicable diseases, and environmental degradation are increasingly recognized as interconnected global challenges, underscoring the need for integrated strategies that simultaneously promote human and planetary health. The Pla...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Ischemic strokes as an initial manifestation of eosinophilic granulomatosis with polyangiitis with eosinophilic myocarditis: a case report

Abstract Background Eosinophilic myocarditis (EM) is a rare form of myocarditis which may be caused by eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease which frequently affects the heart. The case of a young woman with a rare initial manifestation of EGPA as a...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Kids These Days! A Cross-Temporal Meta-Analysis of Changes in Emotional and Behavioral Problems of Population-Based Samples Over the Past Decades

Abstract There is a general belief that mental health problems are increasing in younger generations, though little objective comparisons exist. The current meta-analysis examines changes in subclinical mean-level overall symptom burden and shifts in specific domains among popula...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

flexiAsCas12a and other Cas12a variants enhance the applicability of Cas12a nucleases in prime editing

Abstract Background Amongst the genome manipulation tools based on the versatile CRISPR-Cas system, prime editing is the most prominent one as a method that enables precise insertions, deletions, and substitutions without inducing double-strand breaks. Cas12a nucleases are widely...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Biomarker changes during long-term noninvasive ventilation in obesity hypoventilation syndrome: a prospective observational study

Abstract Purpose Obesity hypoventilation syndrome (OHS) is a severe form of sleep-disordered breathing and a major contributor to chronic respiratory failure, yet optimal treatment strategies and reliable biomarkers for monitoring therapeutic efficacy remain undefined. This prosp...

Fecal filtrate transplantation as salvage therapy for fulminant Clostridioides difficile infection in adult hematological patients during chemotherapy-induced aplasia: a pilot experience

Background Fulminant Clostridioides difficile infection (CDI) in patients with hematologic malignancies during chemotherapy-induced aplasia carries high mortality and limited treatment options. Our objective was to evaluate fecal filtrate transplantation (FFT) as a salvage therap...