Second Xiangya Hospital of Central South University

Development and exploratory external assessment of a machine learning model for early delirium prediction in non–mechanically ventilated patients with sepsis

Delirium is a common and severe complication of sepsis in critically ill patients and is associated with increased mortality and prolonged hospitalization. Early identification of high-risk individuals remains challenging, particularly among non–mechanically ventilated patients w...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Network analysis of non-suicidal self-injury risk: school bullying, depressive symptoms, and psychotic-like experiences in 15,968 Chinese students

Abstract Background Non-suicidal self-injury (NSSI) is a major public health concern. While several factors have been associated with NSSI, their complex interactions and joint effects on NSSI remain unclear. This study examined the factors associated with NSSI using network anal...

Synaptotagmin family proteins in neurological disorders: from synaptic vesicle fusion to neuronal vulnerability

The maintenance of neuronal and glial homeostasis depends on precise membrane fusion, vesicular trafficking, receptor turnover and stress-response signaling, processes regulated in part by synaptotagmin (SYT) family proteins. SYTs comprise a family of 17 mammalian membrane-associ...

NINJ1 in regulated cell death and cancer: a plasma membrane rupture executor with dual roles in tumor progression

To elucidate the molecular structure, oligomerization mechanisms, and roles of Ninjurin-1 (NINJ1) in regulated cell death (RCD) pathways (pyroptosis, necroptosis, ferroptosis, secondary necrosis, PANoptosis) and its dual role in cancer (tumor suppressor vs. pro-tumor factor). Sys...

Autologous Iliac Crest Bone Graft After Anterior Cruciate Ligament Reconstruction Failure in Patients With Both Femoral and Tibial Tunnel Enlargement

Abstract Tunnel enlargement is a common challenge in revision anterior cruciate ligament reconstruction and compromises graft fixation and biological integration. Traditional 2‐stage revision procedures prolong treatment duration and increase patient morbidity. We describe a tech...

Diagnostic utility of plasma metagenomic next-generation sequencing for bloodstream and localized infections in advanced HIV disease

Abstract Objectives To evaluate the diagnostic performance of plasma metagenomic next‑generation sequencing (mNGS) for suspected bloodstream infections (BSI) and localized infections in patients with advanced HIV disease. Methods We conducted a retrospective observational study o...

Integrative plasma proteomic network analysis identifies physical activity-associated protein modules potentially mediating type 2 diabetes risk

Moderate-to-vigorous physical activity (MVPA) lowers the risk of type 2 diabetes (T2D). Identifying protein modules that mediate this association may help dissect these biological underpinnings, but they remain incompletely characterized. We studied 28,842 diabetes-free UK Bioban...

Double Adjustable‐Loop Cortical Buttons for Minimally Invasive Anatomic Double‐Bundle Medial Patellofemoral Ligament Reconstruction

Abstract Recurrent patellar dislocation is a common condition in young and active individuals, with medial patellofemoral ligament (MPFL) injury being the primary pathological factor in most cases. Anatomic double‐bundle MPFL reconstruction has been established as an effective tr...

Adding salt to foods, genetic susceptibility, and risk of incident osteoporosis

Objectives To investigate the association between the frequency of adding salt to foods and incident osteoporosis and assess effect modification by genetic susceptibility. Design Prospective cohort study. Setting UK Biobank, United Kingdom. Participants 491,428 participants free...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder

Abstract Individuals with methamphetamine use disorder (MUD) exhibited functional and structural brain recovery during abstinence. However, longitudinal neural changes of large-scale brain networks after prolonged abstinence remain unclear. Here, energy landscape analysis was app...

Balancing privacy and performance: the impact of facial defacing on AI in medical imaging

Background Recent NIH Data Management and Sharing (DMS) policy updates and NIH controlled-access data security requirements have increased attention to facial anonymization and controlled-access handling of shared head imaging data. This is particularly relevant for datasets subm...

Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms

AIM: Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the fron...

Reliability and Validity of the Chinese Version of the Parental Acceptance Questionnaire (6‐PAQ) Among Parents of Children With or Without Hearing Loss

ABSTRACT Background The parental acceptance questionnaire (6‐PAQ) is a user‐friendly and contextually sensitive scale of psychological flexibility. Objective This research aimed to translate the original English version of the 6‐PAQ into Chinese and to test its psychometric prope...

Exosome-packaged ILK from healthy female serum stimulate osteogenesis via the MAPK signaling pathway

The pathogenesis of osteoporosis (OP) is multifactorial, with impaired osteogenic differentiation of bone marrow stromal cells (BMSCs) serving as a fundamental pathological basis. Enhancing osteogenesis is a key strategy for OP therapy. Exosomes are recognized as promising cell-f...

Longitudinal Trajectories and Predictors of Supportive Care Needs After Lung Cancer Surgery: A Prospective Cohort Study

AIMS: To explore the trajectories of supportive care needs and identify influencing factors in lung cancer surgical patients. DESIGN: Prospective cohort study. METHODS: Data from 287 patients at a Chinese tertiary hospital were collected at admission (T0), 2 weeks post-surgery (T...

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Appetitive trait profiles in late life: links to eating disorder psychopathology and psychosocial well-being

Abstract Objective Appetitive traits shape eating behaviors across the lifespan, yet their patterns and health correlates in later life remain poorly understood. This study used latent profile analysis (LPA) to identify distinct profiles of appetitive traits among older adults an...