Second Xiangya Hospital of Central South University

Dendrobine Attenuates Cisplatin-Induced Acute Kidney Injury with KEAP1–NRF2 Activation and Reduced Ferroptosis-Associated Stress

Acute kidney injury (AKI) lacks effective pharmacological therapies, and ferroptosis-associated lipid peroxidation contributes to renal tubular injury. Here, we investigated the protective effects of dendrobine against AKI and its mechanisms. Dendrobine was evaluated in murine ci...

Advances in Aerobic Exercise for Pulmonary Arterial Hypertension: Mechanisms of Action and Clinical Insights

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, leading to right heart failure and death in severe cases. PAH is classified as Group 1 pulmonary hypertension (PH). Although Group...

Stable truncating mutations in plakophilin-2 induce arrhythmogenic cardiomyopathy-like phenotypes in adult zebrafish

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by arrhythmias and fibrofatty myocardial remodeling, often leading to heart failure and sudden cardiac death. Mutations in plakophilin-2 ( PKP2 ) represent the most prevalent genetic cause of ACM....

Commutability Assessment of Materials for Serum Copper Measurement Using the IFCC Difference-in-Bias and the CLSI EP30 Approaches

Background: Evidence on the commutability of material for serum copper when assessing multiple material categories and assay pairs remains limited. Methods: We evaluated 21 reference materials for serum copper across four routine colorimetric systems and an inductively coupled pl...

Impulsivity, cognitive inflexibility, and brain network dysregulation in etomidate use disorder: A clinical and EEG microstate study

Etomidate, a short-acting GABA_A receptor modulator and emerging novel psychoactive substance, is increasingly abused non-medically. Despite rising clinical concern, the neuropsychological profiles of etomidate use disorder (EUD) remain poorly characterized, prompting this system...

Ferroptosis-related immune microenvironment and prognostic signature in high-grade endometrial carcinoma: integrated bulk and single-cell analysis

Abstract Background High-grade (FIGO Grade 3) uterine corpus endometrial carcinoma (UCEC) is an aggressive malignancy with limited therapeutic options and a poor prognosis. While ferroptosis is implicated in various cancers, its specific role within the tumor immune microenvironm...

The liver-heart-lung axis in pulmonary arterial hypertension: bidirectional mechanisms, prognostic biomarkers, and clinical integration

Pulmonary arterial hypertension (PAH) is increasingly recognized as a systemic disorder. Liver involvement in PAH is common, ranging from subclinical cholestatic abnormalities and impaired synthetic function to congestive hepatopathy and cardiac cirrhosis, and these changes close...

Ultra‐Sensitive, Decoupled Multimodal Sensing via Dual‐Network Iontronic Organohydrogels

ABSTRACT Flexible sensors capable of mimicking human skin's multimodal perception are highly desired for wearable electronics. However, achieving inherently decoupled detection of multiple physical stimuli in a single device remains a fundamental challenge. Here, a polyacrylamide...

Lactate suppresses T follicular helper cells in lupus in association with metabolic-epigenetic reprogramming

Aberrant CD4⁺ T cell differentiation, particularly the expansion of T follicular helper (Tfh) cells, is a hallmark of systemic lupus erythematosus (SLE) and is critically dependent on metabolic reprogramming. Although altered lactate metabolism has been implicated in autoimmune d...

Progress in research on the generation and applications of vascular organoids

Vascular organoids (VOs) are constructed by directing the differentiation of human induced pluripotent stem cells (hiPSCs) into two key functional vascular cell types—endothelial cells (ECs) and mural cells (MCs). This process generates perfusable, three-dimensional (3D) vascular...

The mediating role of AI anxiety between AI literacy and attitudes towards AI in nursing students: a cross-sectional study

AI is a key driver in the Fourth Industrial Revolution, significantly impacting healthcare. Nursing students’ acceptance and readiness to use AI are crucial for its successful integration. Understanding their perceptions is vital to prepare them for the intelligent healthcare era...

From bowing to fracture

Aims Congenital anterolateral bowing of the tibia represents the prefracture stage of congenital pseudarthrosis of the tibia. However, specific radiological factors which are predictive of fracture remain poorly defined. The aim of this study, therefore, was to investigate whethe...

Quantitative liver stiffness and steatosis burden in subclinical carotid atherosclerosis: associations and incremental utility assessed by explainable machine learning

Whether quantitative liver steatosis and stiffness provide vascular-risk information beyond conventional cardiometabolic factors remains uncertain. We evaluated their multivariable-adjusted associations and incremental utility for identifying subclinical carotid atherosclerosis....

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

ABSTRACT Aberrant macrophage polarization is one of the key mechanisms underlying chronic obstructive pulmonary disease (COPD), but the underlying processes have not yet been fully elucidated. Lactylation is a novel lactate‐derived post‐translational modification and is relativel...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Disrupted copper homeostasis promotes osteopontin-mediated hepatocyte–stellate cell crosstalk in Wilson disease

Wilson disease is a prototypical disorder of copper metabolism in which hepatic copper overload drives progressive liver injury and fibrosis, yet the molecular mechanisms linking copper accumulation to fibrogenesis remain poorly defined. Here, we identify osteopontin (OPN) as a c...

Fibroblast-associated migrasome programs define TSPAN4-driven progression and clinical risk stratification in gastric cancer

Gastric cancer (GC) is a highly aggressive malignancy with poor prognosis, characterized by complex tumor microenvironment (TME) interactions. Migrasomes have been implicated in cancer progression, but their specific roles and spatial correlation in GC remain unclear. Using 10x G...

Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design

PD-1/PD-L1 blockade can produce durable tumor control, yet primary, adaptive, and acquired resistance remain common. Existing accounts often catalogue resistance by cellular compartment, obscuring the coordinated nature of tumor adaptation. Here, we introduce immune-pressure redi...

Timing of oral beta-blocker initiation and 90-day mortality in critically ill patients with acute myocardial infarction: a target trial emulation

Abstract Oral beta-blockers are used after acute myocardial infarction (AMI), but the optimal timing of initiation in critically ill patients is uncertain, and observational early-versus-late comparisons are prone to immortal-time bias. We emulated a target trial of early (≤ 24 h...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...