Second Xiangya Hospital of Central South University

Appetitive trait profiles in late life: links to eating disorder psychopathology and psychosocial well-being

Abstract Objective Appetitive traits shape eating behaviors across the lifespan, yet their patterns and health correlates in later life remain poorly understood. This study used latent profile analysis (LPA) to identify distinct profiles of appetitive traits among older adults an...

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Primary central nervous system histiocytic sarcoma with skull base and ventricular dissemination: a case report and literature review

Abstract Purpose The primary objective of this case report is to highlight the clinical challenges and diagnostic difficulties of histiocytic sarcoma (HS) involving the central nervous system (CNS). This case emphasizes the importance of accurate diagnosis in patients presenting...

Expression of LDHA, Pan-Kla Level and H3K18la associates with clinical progression of laryngeal squamous cell carcinoma

Laryngeal squamous cell carcinoma (LSCC) represents one of the major subtypes of head and neck squamous cell carcinoma (HNSC), imposing substantial health burdens and necessitates comprehensive clinical interventions. Lactylation, a newly discovered protein post-translational mod...

Neuroprotection in the early window: a randomized controlled trial of butylphthalide initiation within 3 hours in acute ischemic stroke

Neuroprotective agents have shown promise in preclinical studies but failed to demonstrate efficacy in clinical trials, potentially due to delayed treatment initiation. The optimal therapeutic window for neuroprotection in acute ischemic stroke (AIS) remains undefined. We aimed t...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Spatially organized regulated cell death-immune coupling in solid tumors: integrating spatial omics with actionable regulated cell death biology

The therapeutic efficacy of immune checkpoint blockade is frequently compromised by the profound spatial heterogeneity of solid tumors, where distinct ecological niches are associated with different patterns of immune engagement. Spatial omics has substantially refined our unders...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Integrated population-based evidence, network toxicology, single-cell profiling, and in vitro studies elucidate mechanisms connecting PAHs to stroke

Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular disease, yet the specific metabolites and cell-type-resolved mechanisms underlying stroke risk remain poorly defined. Here, we applied an integrated multilevel framework comb...

The Structure and Individual Patterns of Emotional and Behavioral Problems in Preschool Children With Autism Spectrum Disorder: Evidence From Network and Cluster Analyses

ABSTRACT This study explored the interactions between emotional and behavioral symptoms in preschool children with autism spectrum disorder (ASD) and identified potential clinical subtypes based on these interrelationships. A total of 1886 preschool children with ASD and 285 age‐...

Competency frameworks for primary care rehabilitation professionals: a scoping review of global practices and implications for developing countries

PURPOSE: Integrated rehabilitation eases chronic mobility dependence, yet competency frameworks struggle to be implemented in resource-limited regions. To map global competency frameworks for primary care rehabilitation professionals and identify specific implications for workfor...

Agentic echocardiography report structuring for cardiovascular prediction and disease association discovery

Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

Stress Hyperglycemia Drives CD4 + T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

ABSTRACT Perioperative stress hyperglycemia is a transient but frequent metabolic disturbance strongly linked to postoperative organ injury and mortality; however, the immunometabolic mechanisms driving this association remain largely undefined. In a two‐center cohort of patients...

ModernizingTraditional Mineral Medicine: Pyrolusite-DerivedMnO2 Nanoplatform for Osteo-Angio-Immunomodulatory BoneRepair

Abstract Pyrolusite, a traditional mineral medicine rich in manganese, has long been used to promote fracture healing; however, its complex composition, limited bioavailability, and poorly defined mechanisms have hindered its modernization and clinical translation. Here, we prese...

Surgical hip dislocation for the phosphaturic mesenchymal tumor of the femoral head and neck: a clinical outcome analysis

This retrospective study aimed to characterize the clinical, radiographic, and biochemical outcomes of surgical hip dislocation (SHD) combined with intralesional curettage and bone grafting for the treatment of phosphaturic mesenchymal tumors (PMT) of the femoral head and neck. A...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...