Second Military Medical University

Hepatitis B virus pregenomic RNA is associated with malignant phenotypes and postoperative survival in HBV-related intrahepatic cholangiocarcinoma

Abstract Background Chronic hepatitis B virus (HBV) infection contributes to infection-associated liver carcinogenesis. However, the biological and clinical relevance of HBV pregenomic RNA (pgRNA), a marker of residual viral transcriptional activity, in HBV-related intrahepatic c...

A Manganese-Chlorella Hydrogel for an Integrated “Remove–Remodel–Repair” Strategy in Pancreatic Cancer Therapy

Abstract Pancreatic cancer faces the challenges of tumor progression and postoperative pancreatic fistula during the perioperative period, which severely affect patient prognosis. In this study, an injectable self-healing multifunctional hydrogel (CMCGel) was developed based on d...

Electrical Pudendal Nerve Stimulation as an Initial Neuromodulation Strategy for Neurogenic Urinary Retention

Background and objective Chronic neurogenic urinary retention often requires assisted emptying and remains challenging to treat. We evaluated whether electrical pudendal nerve stimulation (EPNS) improves bladder emptying and compared short-term outcomes with a standard sacral neu...

The impact of intraoperative small intestine arrangement on postoperative intestinal function recovery in patients with laparoscopic colectomy: A single-center, double-blinded, randomized controlled trial

Abstract Background This study aimed to evaluate the effect of small intestine arrangement on the bowel function after laparoscopic colectomy. Methods A total of 160 patients were randomly divided into two groups. The control group received conventional treatment, while the exper...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

Robotic pancreatoduodenectomy in the high-difficulty tier: a retrospective cohort stratified by PD-ROBOSCORE

As a retrospective feasibility and safety analysis, this study explores the application of robotic pancreatoduodenectomy(RPD) in patients with different PD-ROBOSCORE grades at our center, with a key focus on the safety of RPD for high-difficulty procedures. This study retrospecti...

Long survival in a TP53 germline-mutant glioblastoma with multi‑omics insights

Li-Fraumeni syndrome, caused by germline mutations in TP53 , is associated with a high lifetime risk of various malignancies, including Glioblastoma (GBM). Long-term survival in GBM is extremely rare, and the underlying biological mechanisms remain poorly understood, particularly...

Optimal timing of endoscopic retrograde cholangiopancreatography and laparoscopic cholecystectomy in the management of cholecystocholedocholithiasis: a multicenter retrospective analysis

To compare the clinical outcomes of ERCP combined with laparoscopic LC using both one-step and two-step approaches for the treatment of cholecystocholedocholithiasis, and to investigate the optimal timing for performing LC within two weeks after ERCP. The clinical data of 520 pat...

Middle meningeal artery embolization for chronic subdural hematoma with wedging technique

Abstract Background Chronic subdural hematoma (CSDH) commonly recurs after burr-hole evacuation or conservative management. Middle meningeal artery embolization (MMAE) using ethylene–vinyl alcohol copolymer (Onyx) aims to devascularize the subdural membranes; however, incomplete...

Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation

BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombot...

A pilot prospective study of tislelizumab and axitinib combined with stereotactic body radiation therapy for oligometastatic renal cell carcinoma

<title>Abstract</title> Background The aim of this study is to investigate the efficacy and safety of tislelizumab and axitinib combined with SBRT in the treatment of omRCC. Methods Eligible pts had oligometastases (≤ 5 leisions) and ≤ 1 prior systemic therapy. All patients recei...

A Non-Invasive Transtympanic Bioadhesive Hydrogel for Sustained Delivery of Dexamethasone in Otitis Media Effusion Therapy

Abstract Otitis media with effusion (OME) is a highly prevalent condition characterized by persistent inflammatory effusion in the middle ear cavity. The clinical management of OME remains challenging due to the anatomical inaccessibility of the middle ear, which limits drug effi...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

Endoscopic Intervention and Surgical Treatment of Benign Biliary‐Enteric Anastomotic Stricture: Real‐World Clinical Impact

OBJECTIVES: Although endoscopic interventions and surgery are both used for treating bening biliary-enteric anastomotic stricture (BEAS), their comparative efficacy, safety, and economic impact have not been established. We conducted this study to address that gap. METHODS: Patie...

Metal–OrganicFrameworks (MOFs) for the Deliveryof Small-Molecule Therapeutics

Abstract As cutting-edge porous materials, the properties of metal–organic frameworks (MOFs) are governed by their metal nodes and organic linkers, as well as the assembly mode of these subunits. This allows the loading capacity of MOFs for small-molecule drugs to be readily tail...

Reliability and validity of the modified chinese version of new Cleveland clinic colorectal cancer quality of life questionnaire

The New Cleveland Clinic Colorectal Cancer Quality of Life Questionnaire (CCF-CaQL) was developed to assess postoperative quality of life (QoL) in patients with colorectal cancer (CRC). Since its introduction, it has been validated in several countries. This study aimed to evalua...

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

ABSTRACT Diabetic foot ulcers are a major complication of diabetes characterized by persistent inflammation and impaired tissue repair, in part driven by aberrant activation of the cGAS‐STING innate immune pathway. Precision immunomodulation in the protease‐rich wound microenviro...

State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait

Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor c...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

Surgical treatment of pancreatic cancer in China: Annual data report of China Pancreas Data Center (2020–2021)

Abstract Objective: The China Pancreas Data Center (CPDC) was established in 2015 with the support of the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association and initiated prospective data collection in 2017. This article reports contem...