Second Military Medical University

CD147+ Cancer‐Associated Fibroblasts Promote PD‐L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL‐6 Signaling

BACKGROUND: Targeting CD147 on hepatocellular carcinoma (HCC) cells has demonstrated therapeutic efficacy. Cancer-associated fibroblasts (CAFs) have been identified as critical components of the tumor microenvironment. The role of CD147 in CAFs is still unclear, and this study ai...

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Reprogramming NOX4-associated ferro-aging with an iron-chelating senescent-cell-targeted therapy for intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) has been a major contributor to chronic low back pain, yet effective disease-modifying therapies remain limited. Here, we identified a NOX4-associated ferro-aging program linking iron overload, oxidative stress, lipid peroxidation, and cell...

FGF-23 is associated with increased risk of abdominal aortic calcification

Fibroblast growth factor 23 (FGF23) is involved in the regulation of phosphate metabolism and has been linked to vascular calcification. However, the genetic association between FGF23 and abdominal aortic calcification (AAC) remains unclear. We conducted a bidirectional two-sampl...

Bile acid signaling in health and disease

Abstract Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecules that act through ligand-, receptor-, and tissue-specific mechanisms to maintain systemic homeost...

Development and application of simple self-locking surgical tubing tourniquet for laparoscopic Pringle maneuver

Pringle maneuver is a critical technique for controlling hepatic inflow and minimizing blood loss during laparoscopic liver resection. However, traditional methods of performing this maneuver can be cumbersome in laparoscopic settings. This study introduces a simple self-locking...

Polarization-sensitive self-powered ultraviolet detection and image encryption enabled by RbCu2I3/SiC heterostructure

Polarization-sensitive self-powered ultraviolet photodetectors are of great significance for advanced target recognition, machine vision, and artificial intelligence, particularly in complex optical environments where multidimensional information extraction is critical. We report...

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

ABSTRACT Background : Everolimus (EVE) is a key treatment for advanced clear cell renal cell carcinoma (ccRCC), mainly targeting AKT/mTOR signaling. However, developed resistance remains a major challenge for EVE treatment. Aberrant alternative splicing, particularly regulated by...

Integrated single-cell and spatial transcriptomic analysis characterizes a TNBC-enriched EP5-associated malignant epithelial program and prioritizes REEP4 in breast cancer

Triple-negative breast cancer (TNBC) exhibits pronounced epithelial-state plasticity, aggressive clinical behavior, and heterogeneous responses to immune checkpoint blockade (ICB)-based neoadjuvant therapy. Bulk transcriptomic analyses cannot resolve epithelial-state heterogeneit...

Enantioselective Synthesis of Azahelicenes via Rh-Catalyzed C–H Functionalization of 6-Hydroxyisoquinoline Derivatives with Alkynes

Abstract Herein, we report an asymmetric C–H functionalization of 6-hydroxyisoquinoline derivatives and annulation with internal alkynes. The reaction is catalyzed by a chiral cyclopentadienyl (Cp)-Rh complex in combination with a modified chiral amino acid. A series of azahelice...

Mechanical Programming of Hollow DNA Nanocapsules Rewires In Vivo Trafficking

ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engine...

Hospice care volunteers’ experiences of reflecting on life meaning: a descriptive phenomenological study

Hospice care volunteers are an important part of spiritual care in hospice settings. Through active listening and dialogue, they can help terminally ill patients rediscover and affirm the value of life and the meaning of existence that may have been obscured during illness. Howev...

Mechanical Programming of Hollow DNA Nanocapsules Rewires In Vivo Trafficking

ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engine...

Infrapopliteal runoff status predicts mid-term outcomes after endovascular popliteal artery aneurysm repair

This study aimed to evaluate mid-term outcomes after endovascular repair (EPAR) for popliteal artery aneurysms (PAAs), with a specific focus on identifying prognostic factors for adverse events after EPAR, particularly the impact of infrapopliteal runoff status. Open surgical rep...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Sinter-Resistant N-Doped Biomass-Derived Carbon-Supported Pd Catalyst for Hydrogenation of Phenol to Cyclohexanol

Abstract Selective hydrogenation of lignin-derived phenols provides saturated cyclic oxygenates relevant to renewable fuel synthesis. Pd nanoparticles were supported on N-doped biomass-derived carbon (Pd/NBC) and evaluated for consecutive phenol hydrogenation to cyclohexanol. Pd/...

An iPAS-optimized phage cocktail delivered by a skin-derived ECM hydrogel for antimicrobial-regenerative treatment of seawater immersion wounds infected with MDR E. coli

Seawater immersion (SWI) wounds are prone to multidrug-resistant (MDR) bacterial infections and impaired tissue repair, yet dual-function wound dressings that combine robust antibacterial activity with proregenerative capacity remain scarce. Through shotgun metagenomic sequencing...

Catalytic Asymmetric Spiroannulation to Access Polycyclic Spiro Enones via Transient Axial-to-Point Chirality Induction and Transfer

Chiral spirocycles exhibit tremendous potential in drug discovery and asymmetric synthesis, owing to their unique three-dimensional rigid framework and superior stability. However, stereoselective construction of polycyclic spiro compounds through a single catalytic transformatio...

Hepatitis B virus pregenomic RNA is associated with malignant phenotypes and postoperative survival in HBV-related intrahepatic cholangiocarcinoma

Abstract Background Chronic hepatitis B virus (HBV) infection contributes to infection-associated liver carcinogenesis. However, the biological and clinical relevance of HBV pregenomic RNA (pgRNA), a marker of residual viral transcriptional activity, in HBV-related intrahepatic c...