Second Affiliated Hospital of Nanchang University

miR ‐15a‐5p Regulates Ferroptosis in Glioblastoma by Targeting GLS2

ABSTRACT Aims Glioblastoma (GBM) remains the most lethal primary brain tumor, and the molecular mechanisms driving its aggressiveness are incompletely understood. Recent multi‐omics analyses have identified miR‐15a‐5p as one of the core microRNAs most closely associated with GBM....

Combined assessment of stress hyperglycemia ratio and frailty for mortality risk prediction in critically ill patients with coronary heart disease: insights from the MIMIC-IV database

Critically ill patients with coronary heart disease (CHD) are at high risk of early death. Traditional prognostic models may not fully capture the combined effects of acute metabolic stress and reduced physiological reserve. We hypothesized that integrating the stress hyperglycem...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibi...

Itaconate as a central node in immunometabolism and inflammatory control

Mitochondria serve as central regulators of cellular bioenergetics and inflammatory signaling, integrating metabolic status with immune responses. Disruption of mitochondrial homeostasis, including altered tricarboxylic acid cycle dynamics, redox imbalance, and aberrant reactive...

Root-System-Inspired Core–Shell Microneedles Enable Spatiotemporal Sequential Therapy via ROS Scavenging, Angiogenesis, and Capillary-Driven Lipid Removal for Enhanced Fat Graft Survival

Abstract Background Autologous fat grafting is widely used in reconstructive and aesthetic surgery, but its clinical outcomes are limited by early ischaemia–hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therape...

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target

C-C motif chemokine ligand 2 (CCL2) interacts with cytokines, adipokines, miRNAs, and multiple synovial cell populations. Experimental studies indicate that these interactions can form a CCL2-associated inflammatory amplification network across cell types. In cellular and animal...

Solute carrier family 25 member 32 promotes the proliferation of esophageal squamous cell carcinoma and is associated with immune infiltration

Abstract Esophageal squamous cell carcinoma (ESCC) is a highly invasive and poorly prognosed malignant tumor of the digestive tract. Currently, there are no effective molecular classification markers for ESCC. This study screened out the key gene SLC25A32 based on mitochondrial-r...

Association of the ZJU index with PSA-defined high-risk prostate cancer status and mortality: a population-based cohort study

Prostate cancer (PCa) ranks among leading causes of male cancer mortality, but PSA screening lacks specificity. Metabolic dysregulation drives PCa pathogenesis; however, composite metabolic indices remain underexplored. The ZJU index—integrating BMI, fasting glucose, triglyceride...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...