Second Affiliated Hospital of Nanchang University

H3K18 lactylation promotes Treg/Th17 imbalance via PTPRM-STAT3 axis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits elevated lactate levels and Treg/Th17 imbalance, but underlying mechanisms remain unclear. We found that HCC patients show increased serum lactate correlated with expanded Tregs and reduced Th17 cells. Lactate treatment promoted FOXP3 while...

Associations between non-insulin-based insulin resistance surrogates and pulmonary hypertension due to left heart failure: a multicenter cohort study

Abstract Background Insulin resistance (IR) has been reported to have a close relationship with the development and adverse outcomes of various cardiovascular disorders, while its association with pulmonary hypertension due to left heart failure (PH-HF) remains to be elucidated....

Associations of genetically predicted Helicobacter pylori antibodies with aneurysmal subarachnoid hemorrhage and unruptured intracranial aneurysm

The causal relationship between Helicobacter pylori antibodies and the risk of cerebral aneurysms remains unclear. We used Mendelian randomization analysis to assess the causal relationship between Helicobacter pylori antibodies and the risk of cerebral aneurysms. A genome-wide a...

Novel therapeutics for platinum-resistant ovarian cancer: from biological mechanisms to emerging biomarker-guided strategies

For decades, platinum resistance has remained one of the major barriers to improving outcomes in ovarian cancer. Patients with platinum-resistant ovarian cancer (PROC) generally have shorter overall survival and lower response rates to second-line treatment than those with platin...

PNA-TPP treatment is associated with Drp1-related mitochondrial dysfunction and an enhanced response to cisplatin in A549-derived stem-like spheres

Cisplatin (CDDP) resistance reduces the treatment effect in non-small cell lung cancer. Lung cancer stem-like cells are closely linked to drug tolerance. Mitochondrial dysfunction may affect their stemness and response to treatment. This study examined whether peptide nucleic aci...

Protein Glutamylation: From Cytoskeleton to Signaling

ABSTRACT Protein glutamylation is a reversible post‐translational modification (PTM) that involves the enzymatic addition of glutamate moieties to, and their removal from, target proteins, thereby modulating their activity, stability, localization, and molecular interactions. Ini...

Immune–metabolic heterogeneity and prognostic associations in breast cancer: development of an eight-gene risk model and preliminary functional characterization of NAT2

Abstract Breast cancer is highly heterogeneous, and immune–metabolic interactions within the tumor microenvironment may contribute to differences in clinical outcome. In this study, transcriptomic, clinical, and somatic mutation data from TCGA-BRCA were analyzed, and the prognost...

Association of alternative Mediterranean diet score with the prevalence of hypertension among the US adults

Our study endeavors to explore the relationship between the alternative Mediterranean diet score (aMED), a tool for assessing adherence to the Mediterranean diet, and the prevalence of hypertension in the US population. An analysis was performed using the dataset from the Nationa...

MFSD2A in health and disease: lysolipid transport, barrier physiology, and translational boundaries

Abstract Major facilitator superfamily domain-containing protein 2A (MFSD2A) is a sodium-dependent lysolipid transporter that delivers lysophosphatidylcholine-bound fatty acids, particularly docosahexaenoic acid, across specialized cellular interfaces. This Review synthesizes str...

Non-prescription supportive care interventions for anticancer therapy-induced oral mucositis: protocol for a systematic review and meta-analysis

Abstract Background Oral mucositis (OM) is a common and debilitating complication of anticancer therapies, frequently resulting in pain, nutritional impairment, and potential treatment interruption. While several pharmacologic and device-based interventions have been evaluated, l...

Hepatitis B virus infection and lung cancer risk: evidence from meta-analysis, Mendelian randomization, and integrative transcriptomic analyses

Epidemiological studies have suggested an association between hepatitis B virus (HBV) infection and lung cancer, but the potential causal relationship and shared molecular features remain unclear. This study integrated epidemiological, genetic, and transcriptomic evidence to inve...

Bifidobacterium animalis subsp. lactis delays epithelial ovarian cancer progression by secreting acetate and regulating the NRF2–HO-1–ferroptosis pathway

Recent advances have highlighted the anti-tumour effects exerted by the gut microbiota and its derived metabolites through modulation of ferroptosis; however, their role in epithelial ovarian cancer (EOC) has not been fully explored. Based on qPCR analysis and previous 16S rRNA s...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

Abstract Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunoth...

Albumin-based nutritional-inflammatory indices and prognosis in critically ill patients with acute myocardial infarction: a MIMIC-IV cohort study

This study investigated the associations between 12 albumin-based nutritional–inflammatory indices and adverse outcomes in critically ill patients with acute myocardial infarction and compared their prognostic performance. A retrospective cohort study was conducted using the MIMI...

An interpretable deep learning model based on enhanced CT predicts the recurrence of non-muscle-invasive bladder cancer within 2 years

Accurate risk stratification for non-muscle-invasive bladder cancer (NMIBC) recurrence is essential for personalized treatment. This study aimed to develop and validate a contrast-enhanced computed tomography (CT)-based model for predicting postoperative NMIBC recurrence within t...

The relationship between biological rhythm disturbances and mixed features in major depressive episodes: a multicenter cross-sectional study

Major depressive episodes (MDEs) with mixed features are associated with greater clinical complexity and may represent an important indicator of bipolarity. Biological rhythm disturbances have been implicated in mood disorders, but their relationship with mixed features during MD...

Intergenerational support and risk of incident visual impairment among middle-aged and older Chinese adults: a national longitudinal cohort study

Abstract Background Visual impairment is a major contributor to functional decline and reduced quality of life among older adults. While biological and demographic factors are well established, the role of family-based social support remains unclear. In China, intergenerational s...

Mitochondria–endoplasmic reticulum contacts as signaling platforms in chondrocyte homeostasis and osteoarthritis: from adaptive coupling to pathological amplification

Osteoarthritis (OA) is a progressive whole-joint disease in which cartilage degeneration remains a central pathological event. Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are prominent features of chondrocyte dysfunction, but how these processes are coordinate...