San Sebastián University

Loss of cGAS alters microglial homeostasis, promotes progressive neurodegeneration, and impairs neuroimmune coordination

Abstract Background The cGAS-STING pathway has been extensively studied as a driver of neuroinflammation in the context of brain aging and neurodegeneration. However, whether cGAS plays a homeostatic role in microglial function under physiological conditions — and how its express...

Assessment of Salinity Tolerance in Lepeophtheirus salmonis Following Five Generations of Freshwater Treatment Selection

ABSTRACT Non‐medicinal approaches for controlling sea lice ( Lepeophtheirus salmonis ) infestations, such as freshwater (FW) treatments, have been increasingly implemented to support more sustainable parasite control in aquaculture. This study evaluated the efficacy of FW treatme...

Molecular overview of major salivary gland carcinomas in chilean patients: 2 case reports

Abstract Background Salivary gland tumors (SGTs) are rare neoplasms that account for 8.5 % of head and neck cancers and comprise a highly heterogeneous group of benign and malignant subtypes, according to the World Health Organization. In Chile, epidemiological and molecular data...

Team learning: the role of facilitation in Debriefing

Purpose This study aims to examine how facilitation influences high-quality debriefings as a vehicle for team learning and reflexivity in organizational contexts. Design/methodology/approach We employed an interpretive qualitative design with 23 work teams (n = 112) from diverse...

Gödel-symmetric backgrounds and explicit spacetime symmetry breaking

Abstract Explicit diffeomorphism breaking in gravitational theories with nondynamical background fields is constrained by the compatibility between the modified Einstein equations and the contracted Bianchi identities. We implement an isometry-based approach in which the backgrou...

Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Objectives Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insulin resistance, impaired insulin secretion, and increased cardiometabolic and inflammatory burden. Zinc plays a key biological role in insulin synthesis, storage, signalling and antiox...