Samsung Medical Center

White Blood Cell Counting in Severely Leukopenic Samples on a Sysmex XN Hematology Analyzer: Analytical Performance Evaluation of Whole Blood Mode and Low White Blood Cell Mode

Background: /L. Methods: Precision of WBC quantification in the two modes was evaluated using four samples according to the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) criterion (CV% 5.6). Linearity was evaluated at five concentrations. The two modes...

Epigenetic-Targeting Regimens vs. Conventional Chemotherapy in Relapsed/Refractory PTCL: A Meta-Analysis

PurposeRelapsed/refractory peripheral T-cell lymphoma (R/R PTCL) lacks a uniform salvage standard and outcomes with conventional chemotherapy (CC) remain suboptimal.This meta-analysis compared epigenetic-containing regimens (Epi-Rx) and CC in R/R PTCL. Materials and MethodsWe sea...

Income Dynamics and Incident Esophageal Cancer: A Retrospective Cohort Study

BACKGROUND: Although socioeconomic status is a recognized risk factor for esophageal cancer (EC), most studies have examined socioeconomic status at a single time point. We investigated the association between income dynamics and incident EC. METHODS: We analyzed 3,361,091 Korean...

Preoperative Thoracic Compensation is Associated With a Lower Risk of Proximal Junctional Kyphosis After Lower Thoracic Fusion for Adult Spinal Deformity

Study Design Retrospective cohort study. Objectives To determine whether thoracic compensation (TC) assessed against the deformity burden is associated with proximal junctional kyphosis (PJK) after lower thoracic fusion for adult spinal deformity (ASD). Methods We reviewed 343 pa...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Lipid Burden and Efficacy of Preventive PCI of Vulnerable Atherosclerotic Coronary Plaques: Post Hoc Analysis From the PREVENT Trial

BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...

Early Mitral Valve Surgery and Survival in Asymptomatic Severe Primary Mitral Regurgitation

Importance The optimal timing of mitral valve (MV) surgery in patients with asymptomatic severe primary mitral regurgitation (MR) remains uncertain because randomized clinical trials are lacking. Objective To evaluate the association of early MV surgery with long-term survival in...

Combination strategy of photothermal therapy and targeted IFN-β mutein priming elicits a durable abscopal effect

Metastatic tumors remain difficult to cure due to frequent dissemination and recurrence. While photothermal therapy (PTT) can trigger abscopal effects, PTT monotherapy often fails to sustain systemic immunity. Here, we investigated a tripartite strategy combining PTT, a tumor-tar...

Scoping review of models predicting emergency department length of stay

Emergency Department (ED) length of stay (LOS) is a critical performance indicator in healthcare systems, influencing patient outcomes, overcrowding, and resource utilization. Predicting LOS can enhance patient flow and resource management. While traditional statistical methods h...

Stereotactic body radiation therapy for hepatocellular carcinoma: 2026 expert consensus-based practical recommendation of the Korean Liver Cancer Association

Stereotactic body radiation therapy (SBRT) is a noninvasive, high-precision radiation technique that delivers a high dose to the tumor in a limited number of fractions, typically five or fewer, and is increasingly used as a curative-intent option for hepatocellular carcinoma (HCC...

Development and Validation of a Novel Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry Method for Serum 3-Epi-25-Hydroxyvitamin D 3 , 25-Hydroxyvitamin D 3 , and 25-Hydroxyvitamin D 2

Background: The epimeric form of 25-hydroxyvitamin D3 (3-epi-25-hydroxyvitamin D3, 3-epi-25-OH-D3) can interfere with the accurate measurement of total vitamin D. Therefore, reliable quantification of epimeric metabolites is important for improving measurement accuracy.Here, we d...

Clinical utility of endorectal balloons in prostate cancer external beam radiotherapy: a systematic review and meta-analysis

Purpose: This study aimed to systematically evaluate the clinical utility of endorectal balloons (ERB) for motion management and organ-at-risk sparing in prostate cancer patients receiving external beam radiotherapy (EBRT) or stereotactic body radiotherapy (SBRT). Materials and M...

Factors Affecting Palliative Care Needs Among Individuals With Head and Neck, Lung and Oesophageal Cancers Undergoing Radiotherapy

ABSTRACT Aim(s) To identify the palliative care needs of individuals with head and neck, lung and oesophageal cancers undergoing radiotherapy and explore the factors associated with these needs. Design This cross‐sectional descriptive study involved a survey. Methods Data were co...

Image-guided programming improves motor control in chronic subthalamic nucleus deep brain stimulation in Parkinson's disease: A prospective study

Background Image-guided programming (IGP) enables optimization and personalization of deep brain stimulation (DBS) for patients with Parkinson's disease. Although its role in initial programming has been examined, evidence for its value in chronic stimulation remains limited. We...

Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial

Evorpacept blocks the CD47–signal regulatory protein α interaction, enhancing antibody-dependent cellular phagocytosis. In the phase 2 portion of ASPEN-06 (a multicenter, open-label, randomized phase 2/3 study), 127 patients with pretreated, human epidermal growth factor receptor...

Endpoint genotyping of A2063G and A2064G mutations in Mycoplasma pneumoniae

Abstract Macrolide resistance in Mycoplasma pneumoniae is primarily associated with point mutations in domain V of the 23S rRNA gene, most commonly A2063G and A2064G. Rapid detection of these mutations is important for appropriate antimicrobial therapy. In this study, we develope...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Does a Multi-Location CT Scan Provide a Survival Benefit as Surveillance after Curative-Intent Surgery in Early-Stage Non-Small Cell Lung Cancer?

Purpose: The NCCN guidelines recommend a chest computed tomography (CT) scan every 6 months for 2-3 years for patients with early-stage non-small cell lung cancer (NSCLC). This study aimed to evaluate whether multi-location CT scans offer a survival benefit. Materials and Methods...

Optimizing the Hinge Length of Chimeric Antigen Receptor with a DdFP-Based Immunological Synapse Biosensor

Abstract Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative cancer immunotherapy, employing genetic engineering to express CARs in patient T cells. CARs are composed of a single-chain variable fragment (scFv), hinge, transmembrane, and intracellular si...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...