Samsung Medical Center

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age‐Related Fluoxetine Accumulation in the Elderly

ABSTRACT This study quantified age‐related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data. A PBPK model for fluoxetine...

P1.181. Comparison of the Da Vinci DV5 System With Force Feedback and the Xi Platform in Robotic Transthoracic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background The da Vinci DV5 system incorporates integrated force feedback to enhance tissue handling and precision. By providing real-time tactile information, force feedback may reduce excessive traction a...

Identification of a Pathogenic RECQL4 1.6-kb Deletion–Insertion in a Neonate with Atypical Skeletal Phenotype of Baller–Gerold Syndrome Using Rapid Whole-Genome Sequencing

Mi-Ae Jang, M.D., Ph.D., Ja-Hyun Jang, M.D., Ph.D., Jin Kyu Kim, M.D., Ph.D., Joonhong Park, M.D., Ph.D., Go Hun Seo, M.D., Ph.D., Misun Yang, M.D., Ph.D., Yun Sil Chang, M.D., Ph.D., and Hyun Ho Kim, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2026.0102

ChatGPT for pulmonary rehabilitation in chronic obstructive pulmonary disease is clinically credible but challenging for patients to use

Although interest in applying large language models (LLMs) in healthcare is rapidly growing, their role in supporting pulmonary rehabilitation (PR) for patients with chronic obstructive pulmonary disease (COPD) has not been well established. The primary objective of this study wa...

Clinical Application of Circulating Tumor DNA in Surgically Treated Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is associated with a high recurrence rate and is one of the most aggressive malignancies. Recurrence is mainly detected via imaging modalities; however, postoperative imaging surveillance has disadvantages, including reduced s...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

Real-world genomic landscape of FGFR2 amplifications and fusions in solid tumors: analysis of 4,953 patients using clinical-grade NGS

Fibroblast growth factor receptor 2 (FGFR2) alterations, including amplifications and fusions, are actionable oncogenic drivers in multiple cancers, but their prevalence and genomic features are not well defined. Between October 2019 and October 2024 at Samsung Medical Center, 4,...

Powered Rotational Sheaths in Complex Transvenous Lead Extraction: Comparative Outcomes With Telescoping Sheaths and the WARD‐10 Score

ABSTRACT Background Transvenous lead extraction (TLE) is essential for CIED management and is generally safe with contemporary techniques, although rare cardiac or vascular complications can be life‐threatening. Comparative data between non‐powered telescoping sheaths (TS) and po...

Prospective Head‐To‐Head Comparison of a 10‐Color Single‐Tube Flow Cytometry and EuroFlow Next‐Generation Flow in Multiple Myeloma Minimal Residual Disease

BACKGROUND: Minimal residual disease (MRD) assessment by next-generation flow cytometry (NGF) is an important prognostic tool in multiple myeloma (MM). Although the EuroFlow NGF assay provides highly standardized and sensitive MRD detection, its dual-tube workflow requires larger...

Early On-Treatment Host Fitness Dynamics Refine Prognostic Stratification in Advanced NSCLC Receiving First-Line Immunotherapy

PurposeWe assessed whether baseline and early on-treatment measurements of host fitness using the Prognostic Nutritional Index (PNI) provide complementary prognostic information in advanced non-small cell lung cancer (NSCLC). Materials and MethodsWithin the prospective, multicent...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Risk Factors for Stereoacuity Impairment in Intermittent Exotropia: Results from a Nationwide Korean Study

Purpose: To identify clinical factors associated with stereoacuity impairment in patients with intermittent exotropia (IXT), with an emphasis on perinatal, refractive, motor, and sensory parameters. Methods: This nationwide cross-sectional study analyzed 5,385 Korean patients wit...

Prenatal PM2.5 exposure drives epigenetic reprogramming of fetal macrophages linked to atopic dermatitis

Abstract Prenatal environmental exposures are increasingly recognized as contributors to atopic dermatitis (AD), yet the underlying mechanisms remain unclear. Fine particulate matter (PM 2.5 ), a complex mixture of airborne pollutants, has been associated with elevated risk of al...

Geographic Access to Care and Mortality in Cardiogenic Shock: A Nationwide Cohort Analysis

IMPORTANCE: Timely access to advanced care is critical for patients with cardiogenic shock (CS), yet the impact of regional disparities in hospital arrival time on mortality remains unclear. OBJECTIVES: To investigate whether regional disparities in hospital arrival time are asso...

Phenotyping Sepsis at Emergency Department Presentation Using Early Clinical Data: A Multicenter Cohort Study

Background: Sepsis is heterogeneous, and early emergency department (ED) management is constrained by limited information and dynamic clinical trajectories. Methods: Using the nationwide Korean Sepsis Alliance (KSA) registry, we applied k-means clustering to nine routine ED varia...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Maternal diabetes and childhood cancer risks in offspring: a nationwide cohort study

Maternal diabetes is associated with several adverse childhood outcomes, but its link to childhood cancer remains inconclusive. We investigated this in a nationwide birth cohort using the Korean National Health Insurance database. We analyzed women who delivered singletons betwee...

Factors affecting the performance of standard precautions focusing on the health belief model in South Korea: a cross-sectional study

PURPOSE: This study aimed to examine the factors affecting the performance of standard precautions among third- and fourth-year nursing students. Focusing on the health belief model, it included individual factors such as knowledge of standard precautions, health beliefs, and sel...

Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition—part II: a clinical practice guideline

Purpose: Nutritional therapy is an essential component of intensive care management. Appropriate nutritional support may reduce infectious and metabolic complications and promote recovery in critically ill patients. However, nutritional practices vary across institutions, and int...