Sainsbury Wellcome Centre

Anterior cingulate neurons perform parallel processing of fixated and peripheral information to guide information sampling and choice

Abstract We use our eyes to evaluate objects around us. Models of economic choice emphasise the impact of sequential fixation on valuation and choice, with prefrontal and anterior cingulate cortex (ACC) encoding values of fixated items. Yet whether these regions also evaluate non...

Open source laser-scanning photostimulation for neuroscience with Zapit

Abstract Optogenetic tools are indispensable for understanding the causal neural mechanisms underlying animal behavior, providing millisecond-precision control over genetically defined neural populations. Random-access laser-scanning optogenetics is a powerful and underutilized m...

A mechanistic theory of planning in prefrontal cortex

Abstract Planning is critical for adaptive behaviour in a changing world, because it lets us anticipate the future and adjust our actions accordingly. While prefrontal cortex is crucial for this process, it remains unknown how planning is implemented in neural circuits. Prefronta...