Sahlgrenska University Hospital

Defining catch-up growth in lung function between adolescence and adulthood: A 25-year population-based study

Background Lung function (LF) development from adolescence to adulthood varies widely. Two related but distinct phenomena are relevant: pronounced growth (large positive change in FEV 1 z-score) and classical catch-up (crossing the lower limit of normal). We aimed to quantify bot...

Profiling proteomic responses in small intestinal neuroendocrine tumor GOT1 after [177Lu]Lu-DOTATATE therapy

Abstract Background Peptide receptor radionuclide therapy with [ 177 Lu]Lu-DOTATATE is an established treatment for somatostatin receptor–expressing neuroendocrine tumors. Although strong anti-tumor effects have been demonstrated in experimental models, curative responses in pati...

Bone morphogenetic protein 10 and one-year outcomes after open revascularisation in symptomatic peripheral arterial disease or carotid stenosis

Abstract Background Bone morphogenetic protein 10 (BMP10) has atrial-specific and vascular properties and may reflect both atrial and vascular pathophysiology. We investigated whether BMP10 levels were associated with new-onset atrial fibrillation (AF), major adverse cardiovascul...

Pica, avoidant restrictive food intake disorder and rumination disorder in children and adolescents with autism spectrum disorder: A systematic review

Abstract Background Children with autism spectrum disorder (ASD) have an increased risk of co-occurring eating disorders such as pica, avoidant restrictive food intake disorder (ARFID) and rumination disorder (RD). The aim of the current systematic review was to synthesize and ap...

Hospital at home enables safe and efficient outpatient management of intensively treated acute myeloid leukemia

Abstract Purpose Patients with acute myeloid leukemia (AML) spend a substantial amount of time in hospital while receiving intensive chemotherapy, affecting their quality of life and healthcare costs. This study evaluated the safety of outpatient management of febrile neutropenia...

CT-RSA with induced displacement used for assessment of aseptic loosening of distal femur reconstructions with megaprostheses in patients reporting pain

Aims: The aim of this study was to evaluate the relationship between experienced pain and findings of suspected pathological movement on CT-radiostereometric analysis (RSA) with induced displacement. Methods: Patients with reported pain after distal femur reconstruction with a me...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization

Abstract Synapses, prototypic sites for neuronal communication, are key to brain function. Their organization and properties are instructed by synaptic cell adhesion molecules (sCAMs) that may operate independently or in coordination through yet unknown linker proteins. Here, we...

FOR-HEALTH: study protocol for a randomized controlled feasibility trial of Structured Health Dialogues to improve lifestyle habits and metabolic health in forensic psychiatric inpatients

Abstract Background People with severe mental illness demonstrate markedly reduced life expectancy, largely due to preventable cardiometabolic disease. This burden is particularly pronounced in compulsory forensic psychiatric care, where prolonged inpatient stays, restrictive env...

Trismus and Health‐Related Quality of Life in HNC Patients up to 10 Years Post‐Radiotherapy Completion

ABSTRACT Background This prospective study investigates trismus prevalence, quality of life (QOL), and trismus‐related symptoms in HNC patients up to 10 years post‐radiotherapy (RT). Methods A total of 211 patients with HNC receiving RT were followed pretreatment, 12, 60, and 120...

Hypoadiponectinemia does not enhance anxiety-like behaviour in a lean PCOS-like mouse model

Abstract Polycystic ovary syndrome (PCOS) is characterized by reproductive and metabolic disturbances and is associated with increased symptoms of anxiety and depression. Circulating adiponectin, an insulin-sensitizing adipokine, is reduced in women with PCOS, and low adiponectin...

The Impact of Out-of-Hours Liver Transplantation on Outcomes

Objectives: This national, multicenter retrospective study of 764 adult liver transplantations (LT) in Sweden (2019–2023) employed a data-driven approach to identify the out-of-hours (OOH) high-risk window and evaluate its impact on patient outcomes and health care costs. Summary...

Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology

Abstract Artificial intelligence (AI) is rapidly transforming histopathology, with applications ranging from workflow optimisation and quality assurance to tumour diagnosis, grading, biomarker assessment and estimation of prognosis. While numerous AI algorithms have demonstrated...

Evaluation of the Psychometric Scale Properties of Reflective Functioning Questionnaire (RFQ-8) in Persons with Schizophrenia Spectrum Disorders and Healthy Controls

There is a need to effectively measure mentalization in people with Schizophrenia Spectrum Disorders (SSD) due to its relevance for delusions and hallucinations. The RFQ-8 appears to be an easy-to-administer screening tool for mentalization, but its factor structure is debated. I...

Blood-based biomarkers of Alzheimer’s disease and neurodegeneration in an indigenous African cohort using both Simoa and NULISA platforms

Background: In low- and middle-income countries, Alzheimer's disease and related dementias (ADRD) constitute a growing public health burden. Indeed, the lack of awareness and easy screening tools, such as blood-based biomarkers, leaves many patients undiagnosed. In this study, we...

Hybridisation as an Ecological Process: Admixed Individuals Contribute Substantially to Canopy Biomass in an Intertidal Macroalgal Hybrid Zone

ABSTRACT Beyond its relevance for evolutionary biology and genetics, hybridisation is increasingly recognised as an ecological process that can modify community structure, yet the demographic contribution of admixed individuals in natural primary‐producer systems remains poorly r...

Low-Voltage Ablation in Persistent Atrial Fibrillation

Importance Pulmonary vein isolation remains the foundational ablation approach for atrial fibrillation (AF), yet outcomes in persistent AF remain suboptimal. Targeting low-voltage zones identified by electroanatomical mapping offers a promising strategy for enhancing ablation suc...

Developing an Inventory of Workplace Stress Coping Strategies Among Autistic Adults: A Grounded Delphi Study

Abstract Background Stress levels are often elevated among autistic people, a pattern that also extends to the workplace. Effective coping strategies can reduce the negative impact of stress on work retention and overall wellbeing. However, the unique coping strategies of autisti...

Drones providing live video to dispatch centers during time-critical incidents

Abstract Background Early triage of emergency calls at dispatch centres relies mainly on verbal information, which may not reflect the complexity and severity of a situation, limiting dispatchers situational awareness and early decision-making. Real-time live-video could potentia...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...