Sahlgrenska University Hospital

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Increased neuroplastic activity is associated with cognitive decline in women but not men over an average 6-year follow-up period

Women are disproportionately affected by Alzheimer’s disease compared to men, a difference that may be partly explained by the role of female sex hormones. Estrogen, in particular, may play a key role in neuroplasticity. However, as women age and estrogen levels decline, high lev...

Meeting lifestyle recommendations among cancer survivors – a cross-sectional descriptive analysis from the Swedish CArdioPulmonary BioImage study (SCAPIS)

PURPOSE: This study aimed to describe lifestyle patterns in relation to recommendations -including physical activity, diet, smoking, alcohol consumption, and sleep quality-among Swedish cancer survivors, stratified by sex and age. METHOD: A descriptive cross-sectional study was p...

Progesterone Modulates Protein Synthesis in Osteoarthritic Fibroblast-like Synoviocytes

Knee osteoarthritis (OA) is highly prevalent in women and is characterized by structural joint alterations and synovial inflammatory processes that contribute to pain and impaired mobility. In a previous study, we identified a positive correlation between progesterone levels and...

Effects of E-Cigarette Aerosol Extracts on Human Neutrophil Viability and Inflammatory Responses to Streptococcus mutans

Background/Objective: The increasing use of electronic cigarettes (e-cigarettes) has raised concerns about their possible effects on oral immune responses. Neutrophils are essential for host defense against cariogenic bacteria such as Streptococcus mutans (S. mutans), and impaire...

Colonoscopy quality indicators among nurse endoscopists and physicians in population-based colorectal cancer screening in Sweden

Background In Sweden, a nationwide colorectal cancer (CRC) screening program for individuals aged 60–74 started in 2021; to meet the increasing demand for colonoscopy, nurse endoscopists may play a key role – provided they maintain high technical quality. This observational study...

Predictors of self-rated health in older adults: insights from an anchoring vignettes study

Abstract Self-rated health is one of the most used measures of subjective health in research. At the same time, it presents several methodological challenges. Self-rated health requires individuals to translate their complex, multifaceted health experiences into a single response...

Beyond CD4 counts: Multi‐biomarker assessment of estimated time since HIV ‐1 infection and risk factors for late diagnosis

BACKGROUND: Late diagnosis (LD) of HIV, defined as CD4 count <350 cells/μL or AIDS at diagnosis, remains a substantial public health challenge, with half of individuals in Europe diagnosed late. How long these individuals have lived with HIV remains unclear. We applied a multi-bi...

Real‐world use of automatic insulin delivery pumps in early pregnancy among women living with type 1 diabetes

Abstract Aims To investigate the clinical use, in early pregnancy in women living with type 1 diabetes (T1D), of automated insulin delivery (AID) systems lacking pregnancy‐specific algorithms and to evaluate the maternal and glycaemic outcomes associated with their implementation...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

A National Pediatric Cohort Study on In‐Hospital Cardiac Arrest in Sweden

ABSTRACT Background National data on pediatric in‐hospital cardiac arrest (pIHCA) are limited, and cohorts from highly specialized pediatric centers may not reflect the broader hospital population. We aimed to describe pIHCA reported across Swedish hospitals, with particular focu...

Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales

Abstract Background Digital cognitive testing and plasma biomarkers have emerged as key players for population screening and measuring drug efficacy in clinical trials for Alzheimer’s Disease (AD). Understanding test-retest reliability of these tools is essential to estimate mean...

Sexual health after childbirth: a qualitative study of women’s experiences

BACKGROUND: Sexual health is a vital component of overall well-being but receives limited attention in postpartum care. This study aimed to explore how pregnancy and childbirth shape women's experiences of sexual health, and to identify how care and support can be tailored to pro...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Upfront surgery vs. neoadjuvant therapy in pancreatic cancer with venous involvement: a multicenter retrospective analysis

Abstract Introduction The benefits of neoadjuvant therapy (NAT) for pancreatic cancer (PC) with portal venous involvement remain debated. This study aimed to compare the short- and long-term outcomes of surgery with or without NAT in patients with PC with suspected venous involve...

Sexual and gender minority parents’ experiences of lactation: a meta-ethnographic review

Abstract Background Although lactation has been widely studied, existing evidence largely reflects heterosexual and cisgender parents’ experiences. Sexual and gender minority (SGM) parents may face distinct embodied, social, and healthcare-related factors that shape lactation and...

Case-based pharmacotherapeutic learning structured around the prescribing optimization method and the WHO 6-step model: Medical students’ views from an exploratory questionnaire study

Abstract Purpose Pharmacotherapy is a core competence for physicians and case-based learning is a valuable teaching method for developing this competence. This study explored medical students’ views on structuring pharmacotherapeutic education around either the Prescribing Optimi...

Sex and age at exposure influence 131I biodistribution and dosimetry in Sprague–Dawley rats

Abstract Background Assessing the biodistribution and absorbed dose of ¹³¹I is crucial for optimisation of radionuclide therapy, as well as for improving risk assessment following nuclear emergencies. After the Chernobyl accident, an increase in thyroid cancer among children was...

Letting patients lead? Practitioners’ experiences of using DIALOG + in psychosis outpatient care – patient involvement, collaborative dynamics, and professional roles

Abstract Background Severe mental illness, such as psychosis, significantly affects many areas of life. Involving patients in their care may enhance engagement and support recovery by ensuring that treatment focuses on their expressed needs. DIALOG + is an intervention, supported...