Rush University Medical Center

Rotator Cuff Tears Part II: Subscapularis Repair, Augmentation, and Tendon Transfer—An International Expert Consensus Statement

PURPOSE: To establish updated international consensus statements on subscapularis repair, graft/patch augmentation and superior capsular reconstruction, and tendon transfers for rotator cuff tears, reflecting new evidence, evolving techniques, and ongoing areas of controversy. ME...

Rotator Cuff Tears Part I: Diagnosis, Nonoperative Management, and Repair of Posterosuperior Tears—An International Expert Consensus Statement

PURPOSE: To establish updated international consensus statements on the diagnosis, nonoperative management, and repair of posterosuperior rotator cuff tears, reflecting new evidence, evolving techniques, and ongoing areas of controversy. METHODS: A consensus process on the treatm...

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

OBJECTIVE: SIRT6 is a nuclear-localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL-800, decreases the severity of age-associated osteoarthrit...

Best practice recommendations for spoken and signed language interpreter-mediated clinical neuropsychological services

Objective: The increasing linguistic and cultural diversity of the United States population has intensified demand for equitable, patient-centered neuropsychological services. Yet, a persistent shortage of bilingual and multilingual neuropsychologists, across both spoken and sign...

Bone Marrow Aspirate Augmentation Reduces Reoperation Rates After Osteochondral Allograft Transplantation of the Knee: A Systematic Review

PURPOSE: To systematically review the clinical, radiographic, and patient-reported outcomes of osteochondral allograft (OCA) transplantation with versus without bone marrow aspirate (BMA) augmentation for the treatment of knee cartilage defects. METHODS: A comprehensive search wa...

Fundamentals of Arthroscopic Surgery Training Program Shows Transfer Validity Through Enhanced Operative Arthroscopic Performance

PURPOSE: To evaluate the content, construct, concurrent, and transfer validity of the Fundamentals of Arthroscopic Surgery Training (FAST) program and to determine whether FAST testing performance correlated with arthroscopic performance in the operating room. METHODS: Participan...

Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis

Study Design Systematic Review. Objectives The objective of this study was to answer two questions: (1) Did the overall survival (OS) of patients with spinal metastatic renal cell carcinoma (mRCC) improve in publications from 2017 and afterwards compared to 2016 and before? (2) D...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

High‐Grade Trochlear Dysplasia Confounds Patellar Height Assessment Using the Magnetic Resonance Imaging‐Derived Patellotrochlear and Radiograph‐Derived Caton‐Deschamps Indices

Purpose To compare patellotrochlear index (PTI) and Caton‐Deschamps index (CDI) measurements between normal and dysplastic trochleae, to evaluate the ability of PTI to discriminate patella alta, and to examine the relation of both indices with functional engagement as represented...

Segmental and Circumferential Hip Labral Reconstructions Both Show Favorable Outcomes in Primary Hip Arthroscopy: A Systematic Review

PURPOSE: To perform a systematic review comparing outcomes of segmental and circumferential hip labral reconstructions for irreparable labral tears. METHODS: A systematic search was conducted across PubMed, Embase, and CINAHL. The search terms used were "(hip OR hip arthroscopy)...

Tibial Tubercle‐Posterior Cruciate Ligament Distance Fails to Capture Pathologic Patellar Lateralization in Trochlear Dysplasia

PURPOSE: To compare tibial tubercle-trochlear groove (TT-TG) and tibial tubercle-posterior cruciate ligament (TT-PCL) distances across grades of trochlear dysplasia (TD) in patients with patellofemoral instability, to evaluate their relations with knee rotation angle (KRA) and pa...

The YTHDF proteins modulate Alzheimer’s disease-associated brain gene signatures

Abstract Gene signatures of Alzheimer’s disease (AD) brains reflect the output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulations. To nominate candidate factors modulating these signatures, we developed a machine learning model...

Quadriceps Tendon Autograft Harvest Technique Affects Both Graft Strength and Cross-sectional Area

Background: Bone–patellar tendon–bone (BTB) autografts have been considered the gold standard for anterior cruciate ligament reconstruction, although the popularity of quadriceps tendon (QT) autografts is increasing. Hypothesis/Purpose: The purpose of this study was to compare th...

Assessing Emergency Clinicians' Needs From Trauma Clinical Guidance: A Mixed-Methods Study.

BACKGROUND: In the United States, emergency clinicians are often the first to care for injured patients in the hospital setting. Current trauma clinical guidance does not consistently meet the needs of emergency clinicians caring for this population. OBJECTIVES: To better underst...

Medial Meniscus Posterior Root Repair Is Associated With Better Function But Persistent Knee Varus Thrust and Reduced Knee Internal Rotation During Gait

Purpose To define gait kinematics and kinetics in patients with medial meniscus posterior root (MMPR) tear and repair, compared with healthy, age‐matched controls. Methods This was a cross‐sectional, observational study conducted between October 4, 2022, and March 3, 2025, and in...

Low-Intensity Distortion Product Otoacoustic Emission Protocols in Infants and Young Children: Contributions of Age-Specific Ear Characteristics

Purpose: Despite almost complete cochlear maturity at birth, distortion product otoacoustic emission (DPOAE) levels in neonates and infants are typically higher than those measured in older children and adults, depending on the type and frequency stimulus, which suggests function...

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

A brucellosis-associated vasculopathy presenting with focal neurological deficit: a case report in a pediatric patient with unique imaging

Brucellosis is the most prevalent bacterial zoonosis worldwide. While neurobrucellosis occurs in 5–7% of the affected adults, it is a rare pediatric complication, with an estimated incidence of 0.8%. Limited knowledge of its presentations, diagnosis, and management leads to a sig...

suPAR Identifies Treatment-Resistant Inflammatory Risk Beyond hs-CRP in Type 2 Diabetes With Coronary Artery Disease: An Ancillary Analysis of BARI 2D

OBJECTIVE To determine whether soluble urokinase plasminogen activator receptor (suPAR) is modified by randomized diabetes and revascularization strategies in patients with type 2 diabetes and coronary artery disease and whether combined suPAR and hs-CRP classification refines re...

Impact of Immunosuppression Type on 30-Day Postoperative Outcomes Following Anterior Cervical Discectomy and Fusion: A Retrospective National Cohort Study of 66,162 Patients

Study DesignRetrospective Cohort Study.ObjectivesPerioperative immunosuppression management in spine surgery lacks robust evidence. Most NSQIP-based ACDF models utilize a binary steroid variable, failing to distinguish corticosteroids from biologics or synthetic DMARDs. This stud...