Rush University Medical Center

Volumetric Wear of Highly Cross-Linked Polyethylene Sockets in Total Hip Arthroplasty Differs Among Brands: A Retrieval Study

Outcomes after total hip arthroplasty (THA) remain limited by wear and wear particle reaction. Although highly cross-linked polyethylene (HXLPE) mitigated this issue, there are major differences among the various brands available. This study quantified, for the first time, the vo...

Implications of Glucagon‐Like Peptide‐1 Signaling for Hemophilic Arthropathy, Joint Inflammation, and Cartilage Degeneration: A Narrative Review

INTRODUCTION: Hemophilic arthropathy (HA) is a progressive, inflammatory joint disease that develops despite effective control of bleeding in people with hemophilia (PWH). Increasing evidence suggests that HA is initiated and then maintained by a complex cycle of synovial macroph...

Facilitating best practices in practicum training in clinical neuropsychology: introducing the North American Association of practicum sites in neuropsychology (NAPSN) organizational training guidelines

INTRODUCTION: The North American Association of Practicum Sites in Neuropsychology (NAPSN) was established in 2023 to support external practicum programs in urban, suburban, and rural areas in the United States and Canada by providing resources for member practicum programs and s...

Anchor‐Free Capsular Augmentation Using the Reflected Head of the Rectus Femoris in Hip Arthroscopy

Abstract Capsular integrity is a key factor in hip stability after arthroscopic procedures. Inadequate capsular closure may contribute to postoperative microinstability, persistent pain, and suboptimal outcomes, particularly in patients undergoing extensive capsulotomy or procedu...

An inducible co-stimulator ligand (ICOSL)-based peptide therapy for proteinuric kidney diseases targeting αvβ3 integrin

Abstract Dysregulated αvβ3 integrin activation in podocytes contributes to proteinuric kidney disease by disrupting podocyte architecture and the glomerular filtration barrier. However, no treatments currently exist that therapeutically target this integrin. We previously identif...

Transarterial embolization in inflammatory arthritis: will rheumatology shape the debate or inherit it?

Abstract The expanding use of transarterial embolization for musculoskeletal pain, most commonly operationalized as genicular artery embolization in osteoarthritis, raises a broader question that rheumatology has not yet systematically addressed: might a vessel-targeted, image-gu...

Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection

Abstract Rationale Among adults hospitalized with acute infection, a recent randomized trial observed no significant average treatment effect of cefepime versus piperacillin-tazobactam on acute kidney injury or death, but fewer days-alive-and-free-of delirium and coma with cefepi...

Does Complexation of Plasma Membrane Cholesterol with Phospholipids Determine its Transbilayer Distribution?

The transbilayer distribution of cholesterol in the plasma membrane is unresolved in that diverse analyses have yielded contradictory results. We now propose a model based on a novel mechanism. It assumes that (a) sterols associate stoichiometrically with phospholipids and (b) th...

Reduced Lumbar Lordosis in Fibromyalgia: Radiographic Evidence of Lumbar Straightening by L1-L5 Cobb Angle

Background: Reduced lumbar lordosis has been observed in patients with low back pain, but lumbar straightening has not been well characterized in fibromyalgia. We hypothesized that fibromyalgia would be associated with reduced lumbar curvature on standing radiographs. Objective:...

Still building the foundation: Why reliability and validity studies in AI remain essential for anatomical sciences education

Artificial intelligence (AI) has moved from speculative novelty to an everyday presence among both learners and educators in medical education, with applications spanning tutoring, assessment, feedback, and support for clinical reasoning.[1][2][3][4][5][6][7] Within the anatomica...

Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain

Abstract Alternative polyadenylation (APA) has a central role in regulation of the fate of mRNA and exhibits high variability in the brain and in neurons. However, brain APA regulation has not been mapped at cell type resolution, and the genetic control of APA in brain cell types...

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Single-cell atlas of transcriptomic vulnerability across brain disorders

Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited 1,2 . Here, to gain deeper insights into the aetiolo...

AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data

The complexity of Alzheimer’s disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms. However, the etiology of these phenotypes remains elusive. To address this, the PsychAD project generated a population-level single-n...

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...

The amyloid plaque proteomes of Alzheimer’s disease and mild cognitive impairment

Amyloid plaques contain numerous proteins in addition to amyloid beta in Alzheimer’s disease (AD). Previous localized proteomics identified plaque-associated proteins in late-onset AD, early-onset AD, rapidly progressive AD, preclinical AD, and AD in Down syndrome, although most...

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...

Single-nucleus transcriptome-wide association study of human brain disorders

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...

Single-nucleus atlas of cell-type specific genetic regulation in the human brain

Abstract Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of th...