Royal College of Surgeons in Ireland

Building families—Implementing balanced sexual and reproductive health

Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

An umbrella review of public health interventions to mitigate air pollution and improve health outcomes in high-income countries

Abstract Introduction Air pollution remains a major contributor to morbidity and mortality in high income countries (HICs), particularly in urban environments where traffic and other combustion sources dominate emissions. This umbrella review aimed to synthesise evidence on inter...

Building Families—Implementing Balanced Sexual and Reproductive Health

ABSTRACT One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

Longer hospital stay but similar one-year mortality and readmission after combined proximal humerus and proximal femur fragility fractures: a Propensity-Score–Matched Cohort Study

Abstract Background Fragility Proximal Humerus (PH) fractures are common and often associated with significant morbidity and mortality. Unlike Proximal Femur (PF) fractures, PH fractures are often omitted from established orthogeriatric multidisciplinary team (MDT) pathways. Comb...

Single-nucleus transcriptomic analysis reveals subfield-specific cell-to-cell synaptic reorganisation of the mouse hippocampus in focal temporal lobe epilepsy

Preclinical animal models are critical tools to study the pathophysiology of epilepsy. The intra-amygdala microinjection of kainic acid in mice recapitulates key features of drug-resistant temporal lobe epilepsy, including unilateral hippocampal pathology and broad resistance to...

Healthcare professionals’ perceptions of a maternal and newborn electronic health record and the role of design in their experiences: a qualitative study

Background Few studies assess the perceptions and experiences of healthcare professionals (HCPs) who use electronic health records (EHRs) within a maternity and newborn care setting. Furthermore, prior research has not specifically focused on the relationship between EHR design a...

Fear Of cancer Recurrence Group-based intervEntion (FORGE): Study protocol for the co-design of a psychological intervention for young adult cancer survivors

Background Fear of cancer recurrence (FCR) represents one of the most frequently reported unmet needs among cancer survivors, with young adults demonstrating heightened susceptibility to its effects. Although a range of specialist-delivered psychological interventions has shown e...

Online peer support in long-term physical health conditions: a feasibility randomised controlled trial

Thirty percent of the UK population live with a long-term physical health condition, and many also experience symptoms of low mood. Limited psychosocial support is currently available for people living with long-term physical health conditions and subthreshold depression, who are...

Birdshot chorioretinopathy without classic birdshot lesions: a multimodal imaging case series

To describe atypical presentations of HLA-A29-associated birdshot chorioretinopathy (BCR) in patients without classic cream-coloured birdshot lesions at presentation and to evaluate the contribution of multimodal imaging to the assessment of suspected early disease. Three patient...

Lessons Learned in the Early Adoption of FaME Across Ireland: A Convergent Mixed‐Methods Implementation Study (FaME Ireland)

BACKGROUND: Falls are the most common cause of hospitalisation amongst older adults in Ireland. Structured exercise programmes are recommended to manage falls, and the Falls Management Exercise (FaME) programme has been shown to reduce falls and improve physical function. However...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Tissue and Cerebral Biofluid Remodelling of tRNA-Derived Small RNA Signatures in Experimental and Human Epilepsy

Small noncoding RNAs are increasingly recognized as important regulators of gene expression in brain diseases including epilepsy. tRNA-derived small RNAs (tsRNAs) including tRNA fragments (tRFs) and tRNA halves (tiRNAs) are emerging as stable and regulated RNA species which respo...

Cardioprotective Effects of Aloe vera-Derived Bioactive Compounds in Myocardial Infarction: A Preclinical Review of Mechanisms and Dosages

Myocardial infarction (MI) is characterized by sudden cardiomyocyte death due to impaired blood supply and remains a leading cause of mortality despite advances in management. Aloe vera, a plant rich in over 75 bioactive compounds, including vitamins, minerals, polysaccharides, a...

Infective Endocarditis in Ireland: A Nationwide Analysis

Introduction: Infective endocarditis (IE) remains a serious life-threatening condition associated with substantial morbidity and mortality. Within the Republic of Ireland, there is limited national data regarding the clinical and economic impact of IE. This study aimed to describ...

P1.119. Oesophageal Squamous Dysplasia Disease Spectrum: Patterns of Progression and Management in a Single-Centre Experience

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Oesophageal squamous dysplasia represents a heterogeneous spectrum of disease ranging from atypia and low-grade dysplasia to high-grade dysplasia (HGD), squamous cell carcinoma in situ (SCCis...

P1.056. FLOT vs CROSS Neoadjuvant Regimens in Esophageal and Esophagogastric Junction Adenocarcinomas: Meta-Analysis of Matched Patient Populations

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant treatment followed by surgical resection is standard of care for locally advanced oesophageal adenocarcinoma. Recent evidence has indicated that FLOT chemotherapy offers superior survival...

Bayesian model discovery for reverse-engineering biochemical networks from data

Abstract The reverse engineering of gene regulatory networks based on gene expression data is a challenging inference task. A related problem in computational systems biology lies in identifying signalling networks that perform particular functions, such as adaptation. Indeed, fo...

Considerations for optimal team-based rheumatology care: a qualitative study exploring the experiences of rheumatology health professionals

Interdisciplinary team-based rheumatology care models are a promising solution for improving access to high quality, equitable care for people with rheumatic and musculoskeletal disorders. There is limited understanding on health professionals’ perspectives on their needs to deli...

Early Outcomes and Complications of Skin Graft Reconstruction for Complex Wounds at a Tertiary Hospital: A Single-Centre Study in Oman

Background: Complex wounds present significant reconstructive challenges owing to impaired healing, infections, and tissue loss. Skin grafting remains a widely used reconstructive technique; however, outcome data from the Gulf region are limited to a few studies. This study aimed...

Evaluation of the Relative Citation Ratio Versus the H-Index as Measures of Citation-Based Scholarly Influence in Academic Neurosurgery

BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...