Royal College of Surgeons in Ireland

P1.056. FLOT vs CROSS Neoadjuvant Regimens in Esophageal and Esophagogastric Junction Adenocarcinomas: Meta-Analysis of Matched Patient Populations

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Neoadjuvant treatment followed by surgical resection is standard of care for locally advanced oesophageal adenocarcinoma. Recent evidence has indicated that FLOT chemotherapy offers superior survival...

P1.119. Oesophageal Squamous Dysplasia Disease Spectrum: Patterns of Progression and Management in a Single-Centre Experience

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Oesophageal squamous dysplasia represents a heterogeneous spectrum of disease ranging from atypia and low-grade dysplasia to high-grade dysplasia (HGD), squamous cell carcinoma in situ (SCCis...

Bayesian model discovery for reverse-engineering biochemical networks from data

Abstract The reverse engineering of gene regulatory networks based on gene expression data is a challenging inference task. A related problem in computational systems biology lies in identifying signalling networks that perform particular functions, such as adaptation. Indeed, fo...

Considerations for optimal team-based rheumatology care: a qualitative study exploring the experiences of rheumatology health professionals

Interdisciplinary team-based rheumatology care models are a promising solution for improving access to high quality, equitable care for people with rheumatic and musculoskeletal disorders. There is limited understanding on health professionals’ perspectives on their needs to deli...

Early Outcomes and Complications of Skin Graft Reconstruction for Complex Wounds at a Tertiary Hospital: A Single-Centre Study in Oman

Background: Complex wounds present significant reconstructive challenges owing to impaired healing, infections, and tissue loss. Skin grafting remains a widely used reconstructive technique; however, outcome data from the Gulf region are limited to a few studies. This study aimed...

Evaluation of the Relative Citation Ratio Versus the H-Index as Measures of Citation-Based Scholarly Influence in Academic Neurosurgery

BACKGROUND AND OBJECTIVES: Evaluating citation-based scholarly influence among academic faculty is foundational to academic medicine, as retention, promotion, and tenure to govern career advancement at every level. The h-index has been the standard metric across fields, including...

SKY92 Identifies High‐Risk Newly Diagnosed Multiple Myeloma With Inferior Progression‐Free Survival and Implicates NUF2 as a Candidate Driver

ABSTRACT Objectives To determine the prevalence and prognostic significance of the SKY92 gene‐expression signature, evaluate minimal/measurable residual disease (MRD), and identify molecular drivers of high‐risk disease in transplant‐eligible newly diagnosed multiple myeloma (TE‐...

Current Techniques for Inorganic Polyphosphate Detection and Characterisation

Polyphosphate (polyP) is an evolutionarily conserved linear polymer of orthophosphate residues with diverse functions across organisms from bacteria to mammals. In addition to its roles in phosphate and energy storage, polyP has been implicated in thrombosis, inflammation, cancer...

Team-Based Outpatient Rheumatology Care: A Scoping Review of Terminology, Team Composition, and Impact on Advancing the Quintuple Aim

Objectives Team-based models of rheumatology care, in which rheumatologists and interdisciplinary healthcare professionals (IHPs) collaborate in care delivery, are increasingly recognized to improve outcomes across all domains of the Quintuple Aim (population health, patient expe...