RIKEN Center for Biosystems Dynamics Research

Lsp2 links early-life diet to adult translation and lifespan in Drosophila

Abstract Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia 1,2 . The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies 3–5...

Quantum Gauge Structure of a Self-Consistent Einstein–Scalar Sector

This paper develops the quantum gauge structure of a self-consistent Einstein–scalar sector constructed in the preceding papers of the series. Starting from the symmetric/projective BV master law of Paper 5 and the native scalar quantum theory of Papers 2–4, it constructs an oper...

Master-Action Ownership of a Self-Consistent Einstein–Scalar Quantum Sector

Description This fifth paper in the series develops the functional gauge and Batalin–Vilkovisky structure underlying the self-consistent Einstein–real-scalar quantum sector constructed in Papers 1–4. Using Lean 4, it builds an untruncated spacetime-jet local-functional framework,...

Master-Action Ownership of a Self-Consistent Einstein–Scalar Quantum Sector

Description This fifth paper in the series develops the functional gauge and Batalin–Vilkovisky structure underlying the self-consistent Einstein–real-scalar quantum sector constructed in Papers 1–4. Using Lean 4, it builds an untruncated spacetime-jet local-functional framework,...

Impact of Inhibitor Size and Flexibility on the Binding Pathways to c-Src Kinase

Abstract The conformational plasticity of protein kinases poses a challenge for inhibitor design, motivating the use of molecular dynamics (MD) simulations to study their dynamic binding processes. While conformational changes are increasingly discussed, the impact of drug compou...

Continuation Anatomy for Periodic Navier Stokes Breakdown

This preprint develops a machine-checked continuation theory for smooth forced periodic three-dimensional Navier–Stokes evolution in a native H2 framework. The central result characterizes the structure of any smooth periodic classical breakdown datum satisfying the stated interf...

Continuation Anatomy for Periodic Navier Stokes Breakdown

This preprint develops a machine-checked continuation theory for smooth forced periodic three-dimensional Navier–Stokes evolution in a native H2 framework. The central result characterizes the structure of any smooth periodic classical breakdown datum satisfying the stated interf...