Queen's University

Selection favors cost-ordered adaptive mutational paths in a stress-magnitude-dependent manner

Abstract Chronic exposure to stress requires adaptive strategies beyond canonical regulatory mechanisms. Stress varies, both qualitatively and quantitatively, across physiological niches and exerts distinct selection pressures on colonizing bacteria. Bacteria employ diverse defen...

Flourishing of School Leaders in England: Headteachers’ Experiences of Flow, Thriving, Resilience, Grit, and Wellbeing

Given the intensification of school leadership roles, often resulting in heightened levels of stress, increasing workload, and ever-expanding challenges, it is important to understand how school leaders attend to and grow their own wellbeing as well as that of those they lead and...

Implementation and evaluation of a technical support center for the Research to Enhance the Adaptation and Implementation of Health Systems Guidelines in LMICs [RAISE] initiative

Abstract Background Capacity-strengthening initiatives for health policy and systems research (HPSR) in low- and middle- income countries (LMICs) are often designed with little consideration of LMIC stakeholder needs. We formed a Technical Support Centre to support research teams...

Insights into the Hospital Experiences of Patients and Caregivers Affected by Sickle Cell Disease in Ontario

Abstract Objectives Sickle Cell Disease (SCD) is a group of inherited blood disorders affecting over 6,500 people in Canada with around 3500 residing in Ontario. Despite frequent interactions with healthcare providers (HCPs), individuals with SCD face barriers such as delays, sti...

Readability and Quality of Online Patient Education Materials: Thyroid Radiofrequency Ablation

OBJECTIVE: To assess the readability and quality of online patient education materials regarding thyroid radiofrequency ablation. METHODS: Google searches were conducted using six search terms related to thyroid radiofrequency ablation, and the top 50 webpages from each search we...

The life, function and death of platelets

Abstract Platelets, the smallest blood cells, weave through health and disease, their history profound, some of their functions yet to be revealed. Terminology often drifts, but by naming with precision, we illuminate understanding, guide newcomers and set a clear path for resear...

Performance-measurement systems as actors and boundary objects: a sociomaterial perspective to the provision of prison services

The paper explores the performance-measurement systems (PMSs) used in the provision of prison services (and their non-human agent role) to reflect on: the role PMSs play in inter-organisational relationships; the boundary objects that connect human and non-human actors across int...

Climate-driven perinatal mental health impacts: A pilot study

Climate change (CC) poses risks to mental health, with pregnant women highly vulnerable due to unique physiological, emotional, and social changes. This study explored the relationship between cognitive appraisal of CC, emotional responses (e.g. eco-anxiety and solastalgia), and...

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Abstract Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor,...

Examining the work experiences of women in healthcare leadership in Canada: a cross-sectional study

Purpose Women's representation in healthcare leadership roles in Canada is increasing, yet limited prospective data exist on their perceptions of empowerment, organizational support, job satisfaction, engagement and well-being. This study explored how women in director-level or h...

Water Insecurity as Health Crisis: Everyday Embodiment and Gendered Vulnerability Among Girls in Ghana’s Upper West Region

In semi-arid Ghana, girls bear primary responsibility for household water collection in communities without on-premises access, a burden intensified by climate change associated with rising temperatures and frequent droughts. Yet little is known about how this responsibility shap...

Reframing HRM for a multipolar world: insights from the Asia-Pacific region

Purpose The purpose of this anthology is to critically evaluate the role of human resource management in International Business within an increasingly multipolar, digitally disrupted and institutionally diverse global environment. By bringing together leading scholars, the collec...

Why do burying beetles bury? Competition and the fitness benefits of parental care

Abstract Parental care increases the fitness of current offspring at a cost to their parents, compromising parental resources for future reproduction. Given this inherent conflict and cost, complex parental care is relatively uncommon. Reliance on a rare and critical resource for...

Non-Hermitian trapping of Dirac exciton-polariton condensates in a perovskite metasurface

Massless Dirac particles avoid trapping because of their exceptional tunneling properties manifested in the so-called Klein paradox. This conclusion stems from the conservative treatment, but so far, it has not been extended to a non-Hermitian framework. Recently, driven-dissipat...

Stereotactic Prostate Cancer Ablative Re‐Irradiation: A Systematic Review and Meta‐Analysis (SPARE)

ABSTRACT Background Stereotactic ablative radiotherapy (SABR) is emerging as an alternative treatment for patients with locally recurrent prostate cancer after previous radiation. This approach allows for precise target coverage while limiting toxicity to surrounding organs. Howe...

Association between preoperative malnutrition and hospital length of stay in adults with major lung resection: A prospective cohort study

BACKGROUND: Postoperative infections remain a frequent complication after lung resection, and malnutrition is highly prevalent in this population. However, evidence on the impact of malnutrition on clinical outcomes following major lung surgery is limited. This study evaluated th...

Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial

Background Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of l...

Med-TDA: Medical Imaging Topological Data Analysis Tool

<ns5:p>Background Topological data analysis (TDA) has gained interest in medical image analysis, but there are no standardized definitions or pipelines to benchmark model performance. Current TDA tools and packages are mainly developed for general machine learning applications, t...

Lights, camera, coopetition: film and television production in a peripheral region

While ‘coopetition’ – the simultaneous competition and cooperation of firms in regional clusters – supports regional value creation, its dynamics in peripheral regions remain underexplored. This research addresses this gap by examining the antecedents of coopetition in the film a...

Global Prevalence of Keratoconus in the Adult Population: A Systematic Review

To synthesize contemporary estimates of adult keratoconus prevalence worldwide and determine how geography, demographics, and study methodology shape reported rates. We systematically reviewed original studies (2019–2024) quantifying keratoconus in adults. We excluded paediatric-...