Pontificia Universidad Católica de Chile

Electoral results affect beliefs about the past: Evidence from Chile

Can electoral outcomes shape voters' perceptions of the past? We argue that electoral outcomes provide informational cues that prompt voters to reinterpret prior conditions, shifting the benchmarks on which accountability rests. We focus on perceptions of crime, a valence issue t...

Andrographolide: Mechanisms and Therapeutic Potential in Alzheimer’s and Parkinson’s Disease

Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by the progressive loss of specific neuronal cell populations and are associated with protein aggregates. Current therapeutic approaches are still limited due to the complex...

Social Class, Social Resources, and Caregiver Burden: A Multiple Serial Mediation in Unpaid Informal Female Caregivers of Older Relatives in Santiago, Chile

This research explored the role of social class as a determinant of the caregiver burden, and the mediating of social resources (perceived and actual). Using a sample of women aged 35 to 65 years who are unpaid caregivers for older relatives in Santiago, Chile, conducting a seria...

Treatment of Greywater with Emerging Contaminants Using Hollow Fiber Membrane Bioreactor

Greywater reuse has emerged as a promising strategy to reduce pressure on freshwater resources, but little is known about the impact that emerging contaminants may have on its safe application. This study evaluated the performance of hollow fiber membrane bioreactors (HFMBs) for...

Subglottic Pressure and Immersion Depth: Key Determinants of Voice Outcomes in Water Resistance Tube Exercise

Purpose: The present study aimed to evaluate the effects of different immersion depth levels and subglottic pressure (P sub ) levels on the oscillatory features of oral pressure (P oral ; frequency, amplitude, and regularity), the degree of glottal adduction, and the subjective p...

Predicting Spatial Variability of PR Protein Concentration in White Grape Juice Using UAV Multispectral Data and Machine Learning

Background: Pathogenesis-related (PR) proteins, primarily thaumatin-like proteins (TLPs) and chitinases, are the principal cause of protein haze formation in white wines, increasing bentonite requirements and affecting winemaking efficiency. However, evaluating their spatial vari...

Magneto-optical detection of spin-orbit torque vector with first-order Kerr effects

Abstract We present a magneto-optical method for quantifying both components of the spin-orbit torque (SOT) effective field vector h_SO in magnetic thin films that, unlike previous complete-vector magneto-optical schemes relying on quadratic Kerr effects for at least one componen...

Two-Level Sketching Alternating Anderson Acceleration for Complex Physics Applications

Abstract. We present a novel two-level sketching extension of the Alternating Anderson–Picard (AAP) method for accelerating fixed-point iterations in challenging single- and multiphysics simulations governed by discretized PDEs. Our approach combines a static, physics-based proje...

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematical...

Loss of cGAS alters microglial homeostasis, promotes progressive neurodegeneration, and impairs neuroimmune coordination

Abstract Background The cGAS-STING pathway has been extensively studied as a driver of neuroinflammation in the context of brain aging and neurodegeneration. However, whether cGAS plays a homeostatic role in microglial function under physiological conditions — and how its express...

Association between fluid balance, muscle strength, and muscle quality in critically ill patients: a retrospective observational study

Abstract Background Intensive Care Unit–acquired weakness (ICUAW) is a frequent complication that significantly impairs functional recovery in critically ill patients. Fluid overload during critical illness has been associated with adverse outcomes, but its relationship with peri...

Probabilistic calibration of a closed-loop cardiac electromechanical model with application to cardiac resynchronization therapy

Abstract Cardiac conduction disorders such as left bundle branch block induce ventricular dyssynchrony and increase the risk of heart failure. Cardiac resynchronization therapy (CRT) improves cardiac function in approximately 70% of patients; however, identifying the optimal paci...

Phonon-based determination of elastic coefficients in the Weyl semimetal TaAs

Reliable determination of elastic properties in topological semimetals is essential for understanding strain-related effects, but is often hindered by methodological and computational limitations. In this work, we combine first-principles phonon calculations with an elastic conti...

Molecular overview of major salivary gland carcinomas in chilean patients: 2 case reports

Abstract Background Salivary gland tumors (SGTs) are rare neoplasms that account for 8.5 % of head and neck cancers and comprise a highly heterogeneous group of benign and malignant subtypes, according to the World Health Organization. In Chile, epidemiological and molecular data...

Varying Gravity from a Modified Fractional Model: Observational Constraints and Slow–Fast Dynamics

We investigate a fractional gravity model in which both the Hubble parameter and the gravitational constant evolve dynamically due to fractional renormalization-group effects. The model incorporates a scalar field coupled to a time-varying G, generating nonlocal corrections chara...

Capturing the Epistemic Uncertainty in Subduction Earthquake Rupture Parameters

ABSTRACT Subduction earthquakes are highly destructive and can trigger devastating tsunamis, highlighting the need for a consistent probabilistic seismic-tsunami hazard assessment. However, current approaches treat both hazards separately: tsunami models use static coseismic slip...

Near-Term Performance Early Warning in Building Projects Using XGBoost and Earned Value Metrics

Abstract Machine learning can contribute to more proactive, data-driven construction project management. However, most research efforts have focused on predicting final project outcomes, which may miss short-term variations that reveal emerging risks, thereby limiting the utility...

Seasonal biogeochemical cycling of permeable sediments in a temperate shelf sea environment

Abstract In highly productive shelf-seas, permeable sediments cover the majority of the benthic environment. However, most research has focussed on shallow environments where currents, tidal flows, terrestrial inputs and benthic productivity have a greater influence than in sedim...

EduCase: A Systematic Framework for Developing Educational Case Studies in Construction and Engineering Education

Abstract Despite the critical role of educational case studies in construction and engineering education (CEE), there is a lack of systematic frameworks for developing effective educational case studies. This study introduces the educational case study development (EduCase) frame...

Researching from the Border: Methodological Decisions, Positioning and Challenges in the Study of Border Impact

Defining border as a phenomenon that articulates social dynamics brings certain challenges in terms of application to the development of research in border studies. In this paper, we review the theoretical and methodological decisions that sought to put this conception of border...