Pontificia Universidad Católica de Chile

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Analysis of metabolic interactions in an artificial consortium including butyrogenic gut microbes

ABSTRACT Cross-feeding interactions shape gut microbial communities and contribute to the establishment of bacteria associated with beneficial fermentation products such as butyrate. However, many gut microbes involved in fiber degradation and butyrate-associated trophic networks...

Comparative transcriptional network analysis reveals ecological specialization in infant-associated species of Bifidobacterium

ABSTRACT Bifidobacterium species are important microorganisms in the infant gut microbiota displaying substantial genomic diversity, yet how this variability is reflected in transcriptional regulatory architecture remains an open question. Here, we integrated pangenome analysis w...

TSD: An Inverse Problem Approach for Recovering the Exoplanetary Atmosphere Transmission Spectrum from High-resolution Spectroscopy

Abstract Our ability to observe, detect, and characterize exoplanetary atmospheres has grown by leaps and bounds over the last 20 yr, aided largely by developments in astronomical instrumentation, improvements in data analysis techniques, and an increase in the sophistication and...

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

PROTEGO Study Protocol: A Cluster Randomised Crossover Trial of Vernix Caseosa Retention for Primary Prevention of Atopic Dermatitis

Summary PROTEGO is a Chilean cluster‐randomised crossover trial of vernix caseosa retention to prevent atopic dermatitis. 1383 mother‐infant dyads will be enrolled and followed for atopic dermatitis until 12 months.

Free Mucosal Grafting Is a Simple Adjunct for Rapid Re‐Epithelization in Septal Perforation Repair

ABSTRACT Objective Mucosal grafting has become more established in rhinology. While it is accepted that free mucosal grafts take to bone and vascularized recipient beds, the use of mucosal grafting on the contralateral side during nasal septal perforation (NSP) repair with vascul...

Old Vines in the Southern Hemisphere: A Review of Their Viticultural, Enological and Cultural Significance

Old vines represent long-lived viticultural systems in which genetic resources, environmental adaptation, traditional management, territorial identity, and cultural heritage have developed over time. Old vineyards preserve historical germplasm and traditional production systems a...

The Disaster of Arborization and What Wildfires Reveal in Central Chile

ABSTRACT In the summer of 2017, the largest wildfires ever recorded in central Chile swept through and devastated the small logging town of Santa Olga. Within hours, decades of work by the timber industry and its laborers were wiped out, leaving no trace of what had been built. A...

A Structured Framework for Translation of the ACNS Standardized Critical Care EEG Terminology Into Spanish

Purpose: The American Clinical Neurophysiology Society (ACNS) Critical Care EEG Terminology provides standardized language for describing electroencephalographic (EEG) patterns in critically ill patients but has not been formally translated into Spanish. We aimed to develop a con...

Technology-Mediated Scaffolding to Support Critical Thinking in Pre-Service Teachers’ Academic Writing

Developing critical thinking skills (CTS) is a central goal of higher education, yet pre-service teachers often receive little explicit guidance on how to apply them in academic or professional writing. This study reports the design, implementation, and initial examination of IDE...

Heat Treatment Effects on Additively Manufactured Polymer Matrix Composites

Additive manufacturing (AM) of polymer matrix composites (PMCs) enables the fabrication of complex, structurally efficient parts, but the layer-wise thermal history intrinsic to processes such as material extrusion, vat photopolymerization, powder bed fusion, and direct ink writi...

A multiomic atlas reveals distinct immune landscapes in preterm and term chronic placental inflammation

Chronic placental inflammation (CPI), an umbrella term encompassing chronic chorioamnionitis, chronic villitis, and chronic deciduitis, is associated with preterm birth (PTB), yet its cellular and molecular determinants across gestation remain poorly defined. Here, we constructed...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Embryos resolve the enigmatic origin of the theropod wishbone

The origin of the avian wishbone (furcula)—present since theropod dinosaurs—remains unsolved. Its homology is still debated, with competing hypotheses proposing derivation from the clavicles, the interclavicle, or both. To obtain comparative developmental evidence, we studied oss...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Improved global stability bounds for two-dimensional plane Poiseuille flow

This work provides new lower bounds on the global (nonlinear) stability limit of pressure-driven two-dimensional plane Poiseuille flow, improving on the energy stability limit italic Re Subscript upper E Re E $\textit{Re}_E$ originally computed by Orr in 1907. Using a computer, w...

Screening and Segmenting: A Consumer Surplus Perspective

We analyze consumer surplus when a monopolist can adjust both prices and product qualities across segments, engaging in secondand third-degree price discrimination simultaneously. We characterize the consumer-optimal segmentation and show that it has a striking structure: Consume...

Geodesic Ability in Unidimensional IRT Models: A Geometric Perspective on Parametrization Invariance

Abstract Psychometric models use latent variables to quantify psychological traits, but statistical and substantive inferences based on these variables may depend on how the latent scale is parametrized. Consequently, the same fitted model can yield qualitatively different conclu...

Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial

Fluid resuscitation in early septic shock has a narrow therapeutic index. Signals of fluid intolerance are frequently present during early resuscitation, yet current resuscitation strategies do not incorporate them to guide when to limit fluid administration. We evaluated whether...