Philipps University of Marburg

Hospital Length of Stay and Associated Factors in Patients with Oral Cavity Cancer in Germany: A Retrospective Multicenter Analysis of Inpatient Administrative Data

Background: Oral cavity cancer is a clinically relevant subgroup of head and neck malignancies and is associated with substantial treatment burden and healthcare utilization. Hospital length of stay (LOS) is an important indicator of inpatient resource use and complexity of care,...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Soziotechnisches Modellieren. Zur Hervorbringung des Schlafs im Schlaflabor und bei der Selbstvermessung

Zusammenfassung Dieser Beitrag analysiert Schlaflaboruntersuchung und digitale Selbstvermessung als Formen soziotechnischen Modellierens, die den Schlaf als wissensförmiges Objekt hervorbringen. Aus praxeologisch-mikrosoziologischer Perspektive untersuchen wir, wie technische Aff...

Developing a core competency framework for psychiatric pharmacists: a Europe-wide e-Delphi consensus study conducted by the European Society of Clinical Pharmacy Mental Health Special Interest Group

Abstract Introduction Consensus on essential clinical activities of psychiatric pharmacists is currently unavailable. Agreement on core non-clinical roles relating to research, education, leadership and management is also unavailable. Consensus on the core clinical and non-clinic...

Long-Term Clinical Outcomes of Symptom Overreporting and Cognitive Underperformance in Adult ADHD Assessments

Abstract Invalid responding can bias clinical judgement, particularly in adult attention-deficit/hyperactivity disorder (ADHD), where rates of symptom overreporting and cognitive underperformance are elevated. Performance validity tests (PVTs) and symptom validity tests (SVTs) ar...

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Although temporal information is ubiquitous in natural vision, the cortex shows strong intrinsic rhythmicity. Recent electroencephalogram (EEG) studies have revealed a component of the visual impulse response function (IRF) resembling a narrow alpha-band (7–13 Hz) filter with a s...

Protein–protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures

Abstract Background Human polygenic phenotypes arise from the combined effects of many genes that interact within molecular networks. Yet, we know little about how the structure of these networks constrains or facilitates the evolution of complex traits. Here, we systematically e...

The effect of violent conflict on the socioeconomic condition of households in Nigeria: the case of Kaduna State

The incidence and intensity of violent conflict in Nigeria have been rising steadily since 2016. However, the states across the country are not equally affected. Moreover, the nature of the conflicts and the conditions under which they occur vary across Nigeria’s states. Relying...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

The outpatient economic burden of respiratory syncytial virus infection in adults aged ≥ 60 years in Germany: results from the BUCOSS study

Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI) in adults aged ≥ 60 years, but data on its outpatient epidemiology and societal costs remain limited. Methods BUCOSS was a prospective observational study conducted over 3...

Phosphoproteomics identifies the DYRK1B protein kinase as a regulator of processing bodies

ABSTRACT Dual-specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) modulates the cell cycle, cell fate during development, and is deregulated in cancer and metabolic syndrome. However, only a few DYRK1B substrates have been defined, so we undertook a phosphoproteomic...

Labor Market Rigidity and Employment: Firm-level Evidence

Abstract We examine the effect of labor market rigidity on firms’ employment decisions in OECD countries using a rich firm-level panel dataset covering 164,048 firm-year observations. Exploiting intertemporal variation in country-level employment protection legislation (EPL), we...

Population turnover and food-web reorganization sustain acetoclastic methanogenesis at 45 °C in tropical paddy soil

Moderately thermophilic temperatures (45 °C) are widely expected to suppress acetoclastic methanogenesis in paddy soils because thermodynamic constraints favor syntrophic acetate oxidation coupled with hydrogenotrophic pathways. However, tropical paddy soils often deviate from th...

Mobile terahertz spectroscopy for in-situ evaluation of structural characteristics in wooden artefacts

Abstract Conserving fragile wooden artworks requires diagnostics that detect minimal structural changes without invasive intervention. We used a robotic-arm terahertz time-domain spectroscopy (THz TDS) system to study the centrepiece of the Marienaltar in Isenhagen Monastery (Han...

Optimal timing of post-therapeutic [131I]NaI whole-body scintigraphy in predominantly low- and intermediate-risk differentiated thyroid cancer: a secondary analysis of prospectively acquired data and a structured literature review

Abstract Background Post-therapeutic [ 131 I]NaI whole-body scintigraphy (ptWBS) is mandatory after radioiodine therapy (RAIT), but the most suitable acquisition time remains uncertain. We compared image interpretability at early and delayed time points in patients with different...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Small molecule inhibitor of orphan GPCR dimerization improves host defense and blood pressure control in mice

Orphan GPCRs of the GPRC5 family regulate macrophage activity and vascular contractility by dimerizing with other GPCRs, but pharmacological modulation of this process has not been explored. We previously identified the dimerization interface of receptor GPRC5B and show here that...

How do visual and conceptual factors predict the object content in typical scene drawings?

Imagine you draw a typical bedroom, your choice of objects is likely to depend on visual occurrence statistics (i.e. the objects present in previously encountered bedrooms) and semantic relations between objects and scenes (i.e. the semantic relationship between the bedroom and i...