Philipps University of Marburg

The need for uncertainty: why probabilistic LSTMs are key to improving flood predictions and enabling learned warning rules

Abstract. Deterministic model predictions can struggle to adequately capture extreme events such as floods and droughts, which are of particular relevance in hydrology. This limitation arises because deterministic models collapse the conditional runoff distribution to a single po...

Subpocket-Aware Fragment-Based Docking Pipeline for Kinase Ligand Design: Methodology and a PKA Case Study

Abstract Protein kinases regulate signal transduction through phosphorylation, and their dysregulation drives diseases like cancer, autoimmune disorders, and Alzheimer’s, making them key drug targets. Fragment-based drug design offers a powerful route to kinase inhibitors but oft...

Mortality risk stratification in contemporary myocardial infarction–related cardiogenic shock: development of AMICS-ADMIT prediction model and benchmarking of established scores

Background Mortality risk stratification in acute myocardial infarction complicated by cardiogenic shock (AMI-CS) remains challenging with heterogeneous temporary mechanical circulatory support (tMCS) use. We developed and temporally validated the admission-based AMICS-ADMIT mode...

Six guidelines for trustworthy, ethical and responsible automation design

Abstract Calibrated trust ( Lee and See 2004 ) is critical for safe and seamless integration of automated systems into society. 1 Users should only rely on a system recommendation when it is actually correct and reject it when it is factually wrong. This requires an accurate trus...

Prospective multicenter study on patient-related outcomes of orbital floor reconstruction using ultrahigh-molecular-weight polyethylene

This prospective, multicenter clinical study evaluated patient-reported outcomes, functional recovery, and quality of life following orbital floor reconstruction using ultra-high-molecular-weight-polyethylene (UHMWPE) implants. The study emphasized both subjective recovery and th...

Changing Prescription Patterns in Pharmacologically Treated Patients with Newly Diagnosed Inflammatory Bowel Disease in German Gastroenterology Practices: A Real-World Study, 2015–2024

Background/Objectives: The therapeutic landscape of inflammatory bowel disease (IBD) has evolved, particularly with the expanding availability of biologic and targeted therapies. This study characterized real-world prescribing patterns among patients with newly diagnosed Crohn’s...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Dual Role of CACNA1C/CaV1.2 in Cardiac and Neuropsychiatric Disease

The CACNA1C gene encodes the α1C subunit of voltage-gated CaV1.2 calcium channels, serving many pivotal functions throughout the body, including in the heart and brain. Clinical and genetic evidence implicates altered expression and/or function of CACNA1C/CaV1.2 in both cardiac a...

Age-related bone mineral density patterns in a large German clinical DXA cohort: device-specific comparisons with international reference populations

In a large German clinical DXA cohort, comparisons with international reference populations were strongly device-dependent. iDXA values were consistently lower, whereas Prodigy Pro values showed closer but age- and cohort-dependent agreement. The data should not be interpreted as...

Effects of crossing distance on components of fitness in two rare rock plants

Abstract To alleviate negative effects of genetic drift on rare plants, it has been suggested to artificially increase gene flow between isolated populations and create new populations by mixing different provenances to maximize genetic variation. However, there is also a risk of...

Between Strain and Strength: A Longitudinal Examination of the Reciprocal Associations Among School Staff’s Self-Efficacy, Attitudes Towards Inclusion, and Emotional Exhaustion

A school district offered online materials, counselling, and workshops to support staff in handling challenging situations across 19 inclusive schools. A formative evaluation accompanied the project. A two-wave survey about one year apart (NT1 = 835; NT2 = 800) examined stability...

Development and Nationwide Multicentre Evaluation of Guideline-Grounded Large Language Model Chatbots to Support Patient Self-Management and Education in Rheumatology

Patients with rheumatic diseases have persistent information needs that are not fully addressed in routine care. We developed and evaluated guideline-grounded, large language model (LLM) chatbots to support patient self-management and education in rheumatology.Ten disease-specifi...

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E6...

OsteoCHAT: real-world patient evaluation and benchmarking of a guideline-grounded osteoporosis chatbot

Patients with osteoporosis have information needs that routine care inconsistently addresses. In this multicenter real-world evaluation, the LLM-based, guideline-grounded chatbot OsteoCHAT showed high participant acceptability and achieved expert-rated answer quality comparable t...

AI-enabled marketing analytics for SMEs: multimethod evidence on application potential and adoption conditions

Abstract Artificial Intelligence (AI) is transforming marketing analytics by enabling advanced data processing, predictions, and decision support. However, small and medium-sized enterprises (SMEs) often face substantial barriers to AI adoption due to limited organizational, tech...

Psychological resilience as a key pathway between depression and executive functioning in epilepsy

Introduction In epilepsy, the burden of depression extends beyond mood, often accompanying difficulties in executive functioning. However, the psychological factors shaping this relationship remain largely unexplored. This study examines whether psychological resilience serves as...

Rheumatologists’ expectations and perceptions of T-cell redirecting therapies: results from a cross-sectional survey

Abstract T-cell redirecting therapies (TCRTs), including Chimeric antigen receptor (CAR)-T cells and T-cell engagers (TCEs), are emerging as transformative treatments for autoimmune diseases. However, clinical application is currently restricted to specialized centers, leaving mo...

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Exploring the dimensional structure of the Thought and Language Disorder scale in acute psychiatric inpatients

Aims To explore the dimensional structure of the Thought and Language Disorder scale (TALD) in a sample of acute psychiatric inpatients and to contribute to a characterization of the latent dimensions underlying formal thought disorder (FTD). Methods A total of 250 acute patients...

Associative changes in human learning when cues with different learning histories are trained in compound.

The present experiments investigated associative changes during compound training involving cues with different learning histories. Across three human predictive learning experiments using the compound test procedure (Rescorla, 2000), participants learned about the effects of foo...