Peking University People's Hospital

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Novel Compound-Heterozygous Variants in PYCR1 Expand the Variant Spectrum of Autosomal Recessive Cutis Laxa

Background and Objectives: Autosomal recessive cutis laxa (ARCL) is a genetically heterogeneous group of connective-tissue disorders characterized by loose, inelastic skin and variable systemic involvement. Biallelic variants in PYCR1 are associated with PYCR1-related ARCL, inclu...

Accelerated Charge Recombination in MOF Cocrystals Enables Efficient NIR‐Driven Photothermal Polymerization

Understanding charge transfer across donor-acceptor interfaces is essential for designing high-performance optoelectronic materials. Herein, we construct host-guest metal-organic framework (MOF) cocrystals employing a calcium-based naphthalenediimide (NDI) host and electron-rich...

Accelerated Charge Recombination in MOF Cocrystals Enables Efficient NIR‐Driven Photothermal Polymerization

ABSTRACT Understanding charge transfer across donor‐acceptor interfaces is essential for designing high‐performance optoelectronic materials. Herein, we construct host‐guest metal‐organic framework (MOF) cocrystals employing a calcium‐based naphthalenediimide (NDI) host and elect...

Redistribution of CD73 Expression on CD4+T Subpopulations in Systemic Lupus Erythematosus and Its Association With Disease Activity

ABSTRACT Systemic lupus erythematosus (SLE) is a complex autoimmune disorder driven by aberrant immune responses, predominately CD4 + T cells dysfunction. CD73, an ecto‐5′‐nucleotidase mediating adenosine signalling, is essential for immune regulation. Herein, we investigated CD7...

Case report: Twin pregnancies with heterozygous GDF2-related hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder characterized by recurrent epistaxis, mucocutaneous telangiectasia, and arteriovenous malformations (AVMs). Only a few cases related to the variants of the GDF2 gene have been described. Pregnan...

Heterogeneous social participation profiles and socioecological correlates among community-dwelling older adults: a latent profile analysis

Abstract Background Social participation in later life is often summarized using an aggregate score, which may obscure distinct configurations of everyday, social, and volunteering activities. This study aimed to identify latent social participation profiles among community-dwell...

Optic Disc and Retinal Strain Due to Vertical Duction

Purpose: To compare two-dimensional optic disc and retinal vessel strains due to vertical versus horizontal eye rotations in younger and older subjects using confocal scanning laser ophthalmoscopy (cSLO). Methods: In a younger subject group (n = 10; range, 18-39 years; mean age ±...

B3GNT3 defines a spatially restricted dysfunctional T-cell niche and predicts immunotherapeutic outcomes in lung adenocarcinoma

Abstract Background Immunotherapy response in lung adenocarcinoma (LUAD) remains highly heterogeneous, underscoring the need for biologically informative markers of tumor immune dysregulation. B3GNT3, a glycosyltransferase implicated in several malignancies, is poorly characteriz...

NIR‐Responsive CaMoO 4 /Mo 3 N 2 Heterojunction Modified Biomimetic Periosteum: Synergistic Anti‐Infection and Promotion of Bone Defect Repair

ABSTRACT Treating infected bone defects remains a formidable clinical challenge due to robust bacterial antioxidant resistance and severe microenvironmental deterioration. Herein, an antibacterial biomimetic periosteum (ABP) is rationally engineered by in situ anchoring ultrasmal...

Transcription factor ELF-1 drives inflammatory macrophage to exacerbate AKI by GBP4/NLRs/NF-κB axis

Acute kidney injury (AKI) is an unavoidable complication and critical determinant of prognosis in renal transplantation. M1-polarized macrophages are known to exacerbate AKI progression. Preliminary clinical data reveals a positive correlation between elevated E74-like ETS transc...

Bag-1 modulates lung ischemia-reperfusion injury by regulating BCL-2 family proteins and IP3R-mediated calcium release

Lung ischemia-reperfusion injury (LIRI) involves dysregulated apoptosis and calcium overload. This study explored the role of molecular chaperone BCL-2-associated athanogene 1 (Bag-1) -1 in LIRI pathogenesis. Using an A549 cell model of glucose deprivation/hypoxia-reoxygenation,...

Depleting luminal cysteine with engineered bacteroides vulgatus alleviates experimental colitis by suppressing Th17 differentiation through an ATF6-dependent mechanism

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by dysregulated immune responses, particularly the aberrant activation of T helper 17 (Th17) cells. While microbiome-based therapies show promise, wild-type probiotics often lack specific m...

Barriers and Enablers Influencing Adherence to ERAS Protocols in Gastrointestinal Surgery: A Scoping Review

Background/Objective: Enhanced recovery after surgery (ERAS) is a global surgical quality improvement initiative that aims to improve perioperative care based on evidence-based interventions. Although ERAS protocols in gastrointestinal (GI) surgery result in improved patient outc...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Risk factor analysis and predictive model construction and evaluation of fractional uric acid excretion in Chinese inpatients with type 2 diabetes

Abstract Background and Aims: Fractional excretion of uric acid (FEUA) is currently acknowledged as a new risk factor of nephropathy. Precise measurement of FEUA requires withdraw medication during the washout time and 24h urine sample collecting, not always convenient, fostering...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...