Peking University People's Hospital

Influenza A (H1N1) virus infection complicated by checkpoint inhibitor pneumonitis

Rationale: Checkpoint inhibitor pneumonitis (CIP) is a common, potentially severe adverse event in cancer patients receiving neoadjuvant immunotherapy, with glucocorticoids as the standard first-line treatment. Traditionally, glucocorticoids are avoided in confirmed viral pneumon...

3D Microfluidic Networks Formed by Mechanically Guided Compressive Buckling for Large‐Scale Perfused Tissue Culture

ABSTRACT Engineered tissues and organoids offer transformative potential for drug screening and regenerative medicine, yet their application is constrained by limited size and slow maturation. Despite the development of various channel networks for large‐scale engineered tissue p...

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from cor...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Competitive flow identification and hemodynamic analysis in coronary artery bypass grafting

Low graft flow after coronary artery bypass grafting (CABG) may result from anastomotic stenosis or competitive flow, but differentiating these potential causes using intraoperative flow measurements remains challenging. This study aimed to explore graft-type-specific factors ass...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

Risk Prediction Models and Predictors of Low Anterior Resection Syndrome in Patients with Rectal Cancer: A Systematic Review and Meta-Analysis

Objectives Identifying patients at high risk of low anterior resection syndrome (LARS) after rectal cancer surgery may facilitate early management and improve postoperative quality of life. Several LARS prediction models have been developed, but their predictive performance and m...

Systemic Medication Adjustment and Short-Term Relapse of Cytomegalovirus Retinitis After Allogeneic Hematopoietic Stem Cell Transplantation: A Research Communication

Background: Cytomegalovirus retinitis (CMVR) remains a sight-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Systemic antiviral, immunosuppressive, and anti-infective regimens are often modified because of transplant-related complica...

Risk factors for postoperative recurrence of abdominal wall endometriosis: a meta-analysis and a 24-year clinical cohort study

Abdominal wall endometriosis (AWE) is a common iatrogenic condition following cesarean delivery, yet robust evidence on factors associated with its recurrence remains limited. This study utilizes an integrated evidence synthesis design, combining a primary single-center instituti...

Drop‐on‐Demand Printed Negative Dielectric Anisotropy Liquid Crystal Droplets for Adaptive Complex Beam Manipulation and Assessment

ABSTRACT Adaptive manipulation of vectorial optical fields is important for optical metrology, imaging, and structured light‐related applications, yet existing approaches often rely on bulky or sequentially operated systems. Here we demonstrate an inkjet‐printed negative dielectr...

Calcium dysregulation in synergy with sonodynamic therapy via medroxyprogesterone-targeted and ROS-responsive nanoparticles for endometrial cancer

Effective therapies that enable precise drug delivery and integrated monitoring are urgently needed for fertility-sparing management of endometrial cancer (EC). Although calcium channel blockers (CCBs) exhibit anti-proliferative potential in EC, their poor tumor selectivity and s...

Walking difficulty as a marker of high health need and education-related healthcare response in older adults: a cross-national multicohort study

Health systems need simple ways to identify older adults with high health need and to assess whether healthcare response is distributed according to need rather than social position. Walking difficulty is inexpensive to ascertain and widely harmonisable across ageing cohorts, but...

A Self-Marangoni-Propelled Droplet Microarray for Ultrafast Mixing and Point-of-Care Assay of Acute Myocardial Infarction Biomarkers

Abstract Droplet microarrays hold great promise for acute myocardial infarction (AMI) diagnosis, yet their biosensing performance is often limited by poor mixing efficiency and nonuniform signal distribution. Here, we report a self-Marangoni-propelled droplet microarray featuring...

Active commuting and biological aging: Cross-sectional evidence from the UK Biobank

Objective To investigate whether commuting mode is associated with biological aging, including KDM 's Biological Age Acceleration (KDM-BAA), PhenoAge Acceleration (PhenoAA) and leukocyte telomere length (LTL) based on the UK Biobank (UKB). Methods We performed a cross-sectional s...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Illness uncertainty in individuals with gynecologic and breast cancer: A latent profile analysis and structural equation modeling

Background Gynecologic and breast cancers pose a significant global health burden for women. Illness uncertainty is a common psychological challenge among patients with gynecologic and breast cancers, particularly in settings with limited supportive care resources. This study aim...

Sex-specific effects of early-life arsenic exposure on body weight, arsenic metabolism, and gut microbiome stability in C57BL/6J mice

Arsenic exposure in early-life is strongly linked to health risks for mothers and their offspring. Although the mechanisms by which arsenic induces the toxicity and health impacts remain unclear, the gut microbiome makes key contributions to the metabolism of arsenic. This study...

Association between sarcopenia and hypertension: results from large databases in China and the United States

Sarcopenia and hypertension are prevalent conditions with substantial public health implications. However, whether their association is consistent across different populations remains unclear. This study aimed to investigate the association between sarcopenia and hypertension usi...

Perioperative and Mid-Term Outcomes of Primary Versus Redo Pericardiectomy for Constrictive Pericarditis: A Single-Center Retrospective Cohort Study

Background: Direct comparative evidence between redo and primary pericardiectomy for constrictive pericarditis (CP) is limited to small, uncontrolled series. We compared perioperative and mid-term outcomes between the two cohorts and explored factors associated with all-cause dea...

NCCT-based habitats and peri-tumoral radiomics enhance pre-operative prediction of benign and malignant sacral tumors

Abstract Background Differentiating between benign and malignant sacral tumors is essential for guiding treatment strategies. This study aims to develop a novel approach utilizing non-contrast computed tomography (NCCT) for the accurate classification of sacral tumors. Methods Fr...