Peking University People's Hospital

Level of education is associated with risk of kidney diseases in middle-aged and elderly adults: evidence from the CHARLS

Although numerous studies have indicated that various socioeconomic factors influence the risk of developing kidney disease, clinical evidence regarding the relationship between level of education (LoE) and the risk of kidney disease remains insufficient. This study aims to evalu...

Fine-tuning an ECG foundation model to predict coronary CT angiography outcomes

<title>Abstract</title> Coronary artery disease (CAD) remains a major global health burden. Accurate identification of the culprit vessel and assessment of stenosis severity are essential for guiding individualized therapy. Although coronary CT angiography (CCTA) is the first-lin...

Uncertainty-inspired open-set model for identifying infantile fundus abnormalities

Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

VCT220 is a novel nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA) designed to reduce the complex administration of injectable GLP-1RAs and the limited bioavailability of on-marketing oral agents for obesity care. We conducted a multicenter, randomi...

Influencing Factors of Air Bubble-Induced Pressure Difference in Drainage Tubes: An In Vitro Study

AIM: This study evaluated the effect of the presence of air bubbles in a drainage tube on its pressure difference and analyzed the relationship between air bubble volume, tube diameter, drainage fluid viscosity, and pressure difference. Accordingly, it provides a theoretical basi...

Low Dasatinib Penetration of the Blood–Brain Barrier in Children With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: Evidence From LC‐MS/MS Analysis

ABSTRACT We measured dasatinib concentrations in paired plasma and cerebrospinal fluid (CSF) samples from children with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL). Blood samples were collected from children at 0 h (pre‐dasatinib) and 2 h post‐dasatini...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Pharmacokinetics, pharmacodynamics and safety profile of tapentadol hydrochloride injection: a phase 1 dose-escalation study in patients with moderate to severe pain

Abstract An injectable formulation of tapentadol hydrochloride offers a promising alternative for clinical settings requiring rapid analgesia. However, comprehensive clinical data on the pharmacokinetics (PK), pharmacodynamics (PD), and safety of intravenous tapentadol hydrochlor...

Targeting a CDH1–TK1–dependent DNA Synthesis Pathway Overcomes Chemoresistance in Acute Myeloid Leukemia

ABSTRACT Relapsed and refractory acute myeloid leukemia (AML) remains difficult to treat, in part because leukemic cells adapt to nucleoside analogue‐induced replication stress. Here, we identify thymidine kinase 1 (TK1) as a functional contributor to chemotherapy resistance in A...

Postoperative pulmonary complications after high-altitude thoracic surgery requiring one-lung ventilation: a single-centre retrospective cohort study

Abstract Background Postoperative pulmonary complications (PPCs) are common adverse outcomes after thoracic surgery and one-lung ventilation (OLV). Their reported incidence varies with endpoint definition and ascertainment. Lower inspired oxygen partial pressure may alter periope...

Clinical characteristics and influencing factors of roxadustat-induced central hypothyroidism in patients receiving peritoneal dialysis

Background This study aimed to investigate the clinical characteristics and risk factors of central hypothyroidism (CEH) in peritoneal dialysis (PD) patients treated with roxadustat. Methods This retrospective study enrolled maintenance PD patients followed up at Peking Universit...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...