Peking University First Hospital

Ultrafast 4‐Azidopyridinium‐Based Staudinger (UApS) Ligation for Bioorthogonal Labeling and Imaging

ABSTRACT Fast click reactions that operate efficiently in aqueous buffers are highly desirable across many areas of chemistry, yet remain scarce. Herein, we report an u ltrafast 4‐ a zido p yridinium‐based S taudinger (UApS) ligation that proceeds with large bimolecular reaction...

Depleting luminal cysteine with engineered bacteroides vulgatus alleviates experimental colitis by suppressing Th17 differentiation through an ATF6-dependent mechanism

Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by dysregulated immune responses, particularly the aberrant activation of T helper 17 (Th17) cells. While microbiome-based therapies show promise, wild-type probiotics often lack specific m...

A five-phase evaluation framework for diagnostic and predictive medical artificial intelligence

Artificial intelligence (AI) has advanced rapidly across diagnostic, prognostic, and clinical decision-support applications, yet the pathway from laboratory performance to demonstrable clinical benefit remains fragmented and inconsistently defined. Existing evaluations rely heavi...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

Associations Between Short Video Exposure, Empathy and Attitudes Toward End‐Of‐Life Care Among Nursing Students: A Cross‐Sectional Study

ABSTRACT Aim This cross‐sectional study examined the associations between short video exposure, nursing students' empathy, and attitudes toward end‐of‐life (EOL) care, and tested whether perceived impact is statistically consistent with an indirect pathway in these relationships....

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Abstract Background Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). However, the relationship between 25(OH)D and Hcy remains unclear. To explore the association betwee...

Long-term oncologic outcomes following endoscopic versus surgical resection for GISTs: a propensity score matching analysis in the SEER database

Gastrointestinal stromal tumors (GISTs) are common tumors of the gastrointestinal tract. Endoscopic resection offers minimally invasive advantages, but its long-term outcomes versus surgery remain unclear. This study aims to evaluate the survival outcomes of endoscopic versus sur...

Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies

Abstract Liver sinusoidal endothelial cells (LSECs) form a specialized discontinuous microvascular interface between sinusoidal blood and the hepatic parenchyma. Functioning as a central regulator of hepatic homeostasis, LSECs integrate metabolic, inflammatory, and hemodynamic si...

Development of a deep learning model for detecting and measuring gallstones on computed tomography images

PURPOSE: To develop a deep learning model for the automated detection and measurement of gallstones on non-contrast CT images. METHODS: A total of 3,231 CT scans were retrospectively enrolled as an internal cohort, while 753 CT scans from the public AMOS (Abdominal Multi-Organ Se...

Suspected donor-vessel ischemia in a collateral-dependent right coronary artery occlusion presenting as a de Winter-like pattern with inferior ST-segment elevation: a case report

The de Winter electrocardiographic pattern is a recognized equivalent of ST-segment elevation myocardial infarction and is most commonly associated with acute left anterior descending artery ischemia. Its coexistence with overt ST-segment elevation in another territory is uncommo...

Fixed-cycle oral pomalidomide/lenalidomide-based therapy is associated with durable treatment-free remission in idiopathic multicentric castleman disease with TAFRO syndrome: a single-center retrospective study

Abstract Background Idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD-TAFRO) is a rare and severe subtype of iMCD characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Current treatments often require prolonged or indefinite a...

Diaphragmatic hernia after cryoablation for lung cancer: a case report and literature review

Diaphragmatic hernia can be classified into congenital and acquired subtypes, while the acquired form remains clinically rare. Iatrogenic diaphragmatic hernia, a distinct subtype of acquired diaphragmatic hernia, may occur following invasive procedures involving organs adjacent t...

Coexistence of a free-floating pigmented vitreous cyst and ciliary body cysts

Abstract Background Pigmented vitreous cysts are rare and generally benign intraocular lesions, but their origin remains uncertain. This case is noteworthy because multimodal imaging documented a free-floating pigmented vitreous cyst together with small bilateral temporal ciliary...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...