Peking University First Hospital

Fluoroscopic Catheter-Tip Positioning During Internal Jugular TIVAD Placement in Breast Cancer: A Two-Center Retrospective Cohort Study

Background/Objectives: Fluoroscopy permits direct assessment of catheter course and tip position during totally implantable venous access device (TIVAD) placement. We compared left- and right-sided internal jugular vein (IJV) port placement in breast cancer. Methods: This retrosp...

Diagnosis-related group front-page management, coding patterns and cost structure in diabetic nephropathy

Background: Accurate medical record front-page (discharge summary face sheet) documentation supports diagnosis-related group (DRG) classification and payment review. Evidence on disease-specific management for diabetic nephropathy (DN) remains limited. Objective: To evaluate asso...

Machine‐Learning Prediction of Tumor Comorbidity and Cancer‐Associated Mortality in Patients With Coronary Heart Disease: A 2‐Stage Modeling Study

Background Coronary heart disease (CHD) with concomitant tumors is increasingly prevalent and is associated with a higher mortality. We aimed to develop 2 predictive models to enable early identification of tumor risk in patients with CHD and mortality risk in those with CHD and...

Multi-omics profiling uncovers diagnostic biomarker panel, progression-associated subtypes, and prognostic signature in pediatric mitochondrial disease

Pediatric mitochondrial disease (PMD) is challenging due to its genetic heterogeneity, diagnostic difficulty, and unpredictable trajectories. Current biomarkers lack sensitivity to diagnose PMD or predict its severe course. Here, we show a multi-omics framework with longitudinal...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

Reclassifying No Specific Molecular Profile Endometrial Cancer: A Narrative Review of Molecular Heterogeneity, Prognostic Refinement, and Clinical Management

Molecular classification has transformed the management of endometrial cancer (EC), yet the no specific molecular profile (NSMP) subtype remains a major challenge for precision oncology due to its substantial biological and clinical heterogeneity. This narrative review summarizes...

Competitive flow identification and hemodynamic analysis in coronary artery bypass grafting

Low graft flow after coronary artery bypass grafting (CABG) may result from anastomotic stenosis or competitive flow, but differentiating these potential causes using intraoperative flow measurements remains challenging. This study aimed to explore graft-type-specific factors ass...

GLiM-SAM: Global–local Mamba-enhanced SAM for 3D epilepsy lesion segmentation

Accurate localization of epilepsy foci is critical for surgical decision-making in the preoperative evaluation of drug-resistant epilepsy. However, epilepsy lesions are typically small, have blurred boundaries, and exhibit low contrast with surrounding tissues on MRI scans, posin...

Single-Cell RNA Sequencing deciphers the imbalance of Microenvironment of the Maternal-Fetal Interface in Cesarean Scar Pregnancy.

Cesarean scar pregnancy (CSP) has posed a serious threat to women's reproductive health. The view on its mechanism remained controversial. Here, we performed a single-cell sequencing on villi and decidua from three normal and three cesarean scar pregnancies in patients with a his...

Global epidemiological and genetic burden of rare neurological diseases in children

We assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar. Four neurological conditions were classified as rare childhood neuro...

Effectiveness of a Primary‐Care‐Centered Integrated Care Intervention for Stratified Cardiovascular Risk Control in China: Study Protocol for a Pragmatic Cluster Randomized Controlled Trial

ABSTRACT Introduction Gaps in primary care (PC) restrict its potential as a core foundation of the health system in its response to the growing burden of cardiovascular disease (CVD). China has been promoting County‐wide Tight Medical Alliances to strengthen PC by integrating ser...

RCC1 neuropathy mimics childhood axonal Guillain–Barré syndrome with variable clinical severity and survival

Abstract Aim To assess the phenotype and genotype of 10 new patients with biallelic RCC1 variants who presented with axonal neuropathy, and assess functional consequences in vitro. Method In this retrospective, multicentre, observational study, we identified 10 individuals from s...

Toxicities of cancer immunotherapy: clinical manifestations, underlying mechanisms, and management

Abstract Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has transformed the treatment landscape of multiple malignancies. However, dysregulated immune activation can cause a wide range of toxicities tha...

A Self-Marangoni-Propelled Droplet Microarray for Ultrafast Mixing and Point-of-Care Assay of Acute Myocardial Infarction Biomarkers

Abstract Droplet microarrays hold great promise for acute myocardial infarction (AMI) diagnosis, yet their biosensing performance is often limited by poor mixing efficiency and nonuniform signal distribution. Here, we report a self-Marangoni-propelled droplet microarray featuring...

Association between endometriosis and cardiovascular disease: a population-based cohort study

Background: The relationship between endometriosis and cardiovascular disease (CVD) risk remains unclear. This study aimed to evaluate the association between endometriosis and CVD risk, to examine whether the association was affected by age group, and to exploratorily assess the...

Perioperative and Mid-Term Outcomes of Primary Versus Redo Pericardiectomy for Constrictive Pericarditis: A Single-Center Retrospective Cohort Study

Background: Direct comparative evidence between redo and primary pericardiectomy for constrictive pericarditis (CP) is limited to small, uncontrolled series. We compared perioperative and mid-term outcomes between the two cohorts and explored factors associated with all-cause dea...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Weight Reduction Heterogenicity and Mediators of GLP ‐ 1RAs and Dual Agonists for Individuals With Obesity: A Meta‐Analysis

ABSTRACT Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and dual agonists have become pivotal options for obesity, but marked weight loss heterogeneity remains poorly understood. This meta‐regression analysis aimed to identify factors influencing this heterogeneity. We sear...

Pharmacokinetic and safety interactions between aildenafil and clarithromycin, cimetidine, or rifampin in healthy subjects

Aims Aildenafil citrate, an orally bioavailable phosphodiesterase type 5 (PDE5) inhibitor, is primarily metabolized by cytochrome P450 3A4 (CYP3A4). This study aimed to assess potential pharmacokinetic interactions between aildenafil citrate tablets and cytochrome P450 (CYP)3A mo...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...