Peking University First Hospital

Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies

Abstract Liver sinusoidal endothelial cells (LSECs) form a specialized discontinuous microvascular interface between sinusoidal blood and the hepatic parenchyma. Functioning as a central regulator of hepatic homeostasis, LSECs integrate metabolic, inflammatory, and hemodynamic si...

Development of a deep learning model for detecting and measuring gallstones on computed tomography images

PURPOSE: To develop a deep learning model for the automated detection and measurement of gallstones on non-contrast CT images. METHODS: A total of 3,231 CT scans were retrospectively enrolled as an internal cohort, while 753 CT scans from the public AMOS (Abdominal Multi-Organ Se...

Suspected donor-vessel ischemia in a collateral-dependent right coronary artery occlusion presenting as a de Winter-like pattern with inferior ST-segment elevation: a case report

The de Winter electrocardiographic pattern is a recognized equivalent of ST-segment elevation myocardial infarction and is most commonly associated with acute left anterior descending artery ischemia. Its coexistence with overt ST-segment elevation in another territory is uncommo...

Diaphragmatic hernia after cryoablation for lung cancer: a case report and literature review

Diaphragmatic hernia can be classified into congenital and acquired subtypes, while the acquired form remains clinically rare. Iatrogenic diaphragmatic hernia, a distinct subtype of acquired diaphragmatic hernia, may occur following invasive procedures involving organs adjacent t...

Fixed-cycle oral pomalidomide/lenalidomide-based therapy is associated with durable treatment-free remission in idiopathic multicentric castleman disease with TAFRO syndrome: a single-center retrospective study

Abstract Background Idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD-TAFRO) is a rare and severe subtype of iMCD characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Current treatments often require prolonged or indefinite a...

Coexistence of a free-floating pigmented vitreous cyst and ciliary body cysts

Abstract Background Pigmented vitreous cysts are rare and generally benign intraocular lesions, but their origin remains uncertain. This case is noteworthy because multimodal imaging documented a free-floating pigmented vitreous cyst together with small bilateral temporal ciliary...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...