Peking Union Medical College Hospital

Verrucous porokeratosis with prominent follicular involvement

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Preoperative CT-Derived Stone Burden Metrics for Predicting Stone-Free Status and Operative Time After Retrograde Intrarenal Surgery

Objectives: Non-contrast computed tomography (NCCT) is used before retrograde intrarenal surgery (RIRS) to describe stone size, location, and complexity, but the best way to summarize stone burden remains unsettled. Therefore, we compared multidimensional NCCT-derived burden metr...

Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) of unclear etiology. Dupilumab, a humanized monoclonal antibody binding to interleukin-4 receptor alpha (IL-4Rα), suppresses both IL-4 and IL-13 signaling pathways. However, the therapeu...

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by excessive accumulation of β-amyloid (Aβ) peptides in the brain. Beta-secretase 1 (BACE1), the rate-limiting enzyme in the amyloidogenic processing pathway of amyloid precursor protein (A...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Psychological flexibility, neuroticism, and subjective well-being among medical students: a latent profile and mediation analysis

Medical students’ subjective well-being is closely associated with academic stress, psychological flexibility, and neuroticism; however, the heterogeneity of psychological flexibility and the potential indirect association through neuroticism remain underexplored. The present stu...

A dual-wavelength blue laser platform for integrated diagnosis and therapy in glioblastoma: preclinical evidence

Glioblastoma (GBM) remains clinically intractable owing to dismal prognosis and frequent recurrence. This study aimed to develop a dual-wavelength blue laser platform (450 nm and 405 nm) that integrates laser ablation, photodynamic diagnosis (PDD), and photodynamic therapy (PDT)...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Development and external validation of an interpretable machine learning model for high-frequency hearing loss screening

Early identification of high-frequency hearing loss (HFHL) remains difficult in community settings because conventional audiometric screening requires specialized equipment and trained personnel. We aimed to develop, interpret, and externally validate a machine-learning model usi...

Increased receptor binding and spike glycosylation, remodeled immune escape of surging SARS-CoV-2 subvariant BA.3.2.2/RE.2.2/Cicada

SARS-CoV-2 continues to evolve. The subvariant BA.3.2 (Cicada), a derivative of the Omicron BA.3 subtype first detected in late 2024, harbors multiple spike protein mutations, ORF7 and ORF8 deletions, and has recently evolved sublineages (BA.3.2.1 and BA.3.2.2), rendering it a cr...

Consensus H3N2 HA immunogens incorporating key antigenic mutations elicit broad-spectrum neutralising responses

Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000-2022) using pseudovirus-based neutralisatio...

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment

Abstract Drugs for aging-related diseases may modulate aging itself, but standard clinical trial designs cannot detect such effects. Aging clocks could close this gap, but epigenetic models often yield inconsistent, hard-to-interpret results. In contrast, proteomic clocks, by tra...

Global distribution of lung cancer staging at diagnosis: a systematic review

Lung cancer remains the leading cause of cancer-related mortality worldwide, with stage at diagnosis significantly influencing survival outcomes. This systematic review evaluates global variations in lung cancer stage distribution at diagnosis and examines the associations of soc...

Systemic evaluation of immune cells and cytokines in patients with different clinical severity of Omicron infection

Abstract Immune cells and inflammatory cytokines play pivotal roles in immune response against viral infections. Herein, we performed a comprehensive immunocyte profiling to delineate the variations in immunocyte populations and cytokine levels among patients infected with Omicro...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Outcomes beyond 10 years after laparoscopic uterosacral ligament suspension combined with cervical amputation in young women with pelvic organ prolapse and cervical elongation: a prospective observational cohort study

Abstract Background Pelvic organ prolapse (POP) in young women who desire uterine preservation remains clinically challenging, particularly when apical prolapse is accompanied by cervical elongation. Evidence regarding the long-term durability of laparoscopic uterosacral ligament...

Diabetic plaque calcification: mechanisms, imaging phenotypes, and clinical implications

Diabetes is associated with a higher burden and heterogeneous phenotypes of plaque calcification, which may influence plaque stability and cardiovascular risk. This review examines diabetic plaque calcification as a dynamic process driven by hyperglycemia and other metabolic dist...

Endogenous spermidine biosynthesis contributes to fetal liver megakaryopoiesis and platelet production in mice

Metabolic regulation is increasingly recognized as an important determinant of megakaryocyte development and platelet production, yet the metabolite-level characteristics of primary megakaryocytes from distinct developmental stages and tissue origins remain incompletely defined....

VEXAS Syndrome：Report of One Case.

This article details the diagnosis and treatment of an elderly male patient with VEXAS syndrome who came with fatigue and fever.The patient thereafter developed several clinical manifestations，including macrocytic anemia，tracheal and bronchial wall thickening，polyarthritis，ra...

Ultrasound-Guided Lumbar Puncture：Experience in Two Difficult Cases.

Lumbar puncture is an important clinical technique.In patients with spinal deformities or those who undergo lumbar surgery，using surface anatomical landmarks for localization is often challenging，and real-time ultrasound guidance can be employed to complete the procedure.This a...