Peking Union Medical College Hospital

Sprayable EGCG-Grafted Alginate Hydrogels Embedded with Platelet Exosomes: Functional Synergy of Immunomodulation and Angiogenesis for Accelerating Burn Wound Healing

Abstract Burn wounds were often entrapped in inflammatory cascades and highly vulnerable to bacterial infection. Meanwhile, accumulated necrotic tissue and impaired vessels further aggravated local ischemia, thereby impeding the wound healing process. Herein, a sprayable hydrogel...

Endoperoxides Show Distinct Reactivity toward Heme and Hemoglobin

Abstract Artemisinin and Yingzhaosu A (YZSA), two endoperoxide-containing natural products with antimalarial activity discovered through China’s historic 523 Project, have long been the focus of global antimalarial research. Many scientific studies have proposed that their endope...

Trends in mortality attributable to complications of medical and surgical care among cancer patients

BACKGROUND: Complications of medical and surgical care (CMSC) are unintentional harms from medical interventions. Their mortality burden among cancer patients remains understudied. We examined trends and disparities in CMSC-attributable mortality among U.S. cancer patients over t...

Outcomes and computational analysis of visceral branches in thoracoabdominal aortic aneurysm endovascular repair: a single-center study

To report the clinical outcomes of endovascular repair for thoracoabdominal aortic aneurysms (TAAA) and to investigate the hemodynamic mechanisms underlying post-operative visceral artery complications using computational fluid dynamics (CFD). A retrospective analysis was conduct...

Characteristics of meta-analyses of multi-indication drugs: a systematic review of systematic reviews

Multi-indication drugs (MIDs) are increasingly common, but their meta-analyses face methodological challenges due to heterogeneity across indications. This review aims to characterize the methodological and reporting approaches of meta-analyses evaluating MIDs. We conducted a sys...

Research Trends in Frailty and Delirium in Older Adults: A Bibliometric Analysis

Background/Objectives: Frailty and delirium represent critical geriatric syndromes with profound implications for older adults’ health outcomes. This study aimed to quantitatively map global research trends and thematic developments in frailty and delirium among older adults thro...

A novel PRPF31 variant associated with autosomal dominant retinitis pigmentosa in Japanese families

BACKGROUND: PRPF31-associated inherited retinal dystrophy is an autosomal dominant form of retinitis pigmentosa (RP), typically caused by haploinsufficiency. Although affected individuals generally exhibit early-onset nyctalopia and progressive visual field loss, the clinical and...

Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study

Abstract Objective The role of geometric-morphological parameters derived from cardiac magnetic resonance imaging (CMR) in assessing and stratifying chronic pulmonary thromboembolism (CPTE) remains unclear. Material and methods We prospectively enrolled 53 CPTE patients (16 with...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Closing the cervical screening cascade gap toward WHO 90-70-90 elimination targets: A systematic review and meta-analysis of 25 studies in 11 countries

The WHO 90-70-90 cervical cancer elimination targets require that 90% of women with screen-detected lesions receive appropriate treatment by 2030. Achieving this target depends on closing cascade gaps from screen-positive to diagnostic resolution. Whether intervention effectivene...

Associations of psoriasis history with general discrimination‐related experiences in US adults

The data underlying this article are publicly available from IPUMS Health Surveys and the National Center for Health Statistics 2023 National Health Interview Survey.

Post-traumatic stress disorder and anorexia nervosa in a patient with chronic arsenic poisoning: a case report and review of literature

We presented the case of a 33-year-old female referring to the ward of gastroenterology for progressive diarrhea, darkening of skin, edema, and numbness in bilateral lower limbs. She had a history of a persistent self-administration of bisacodine and Chinese medicine (Bezoar Anti...

AAV.IVT18-mediated RDH12 gene therapy restores retinal metabolism in Rdh12 knockout rats and patient-derived iPSC-retinal organoids

Biallelic variants in retinol dehydrogenase 12 ( RDH12 ) cause severe inherited retinal diseases (IRDs) with no available treatments. Given the potential risks of subretinal delivery in patients with macular atrophy, we evaluated intravitreal AAV-mediated RDH12 gene augmentation....

Cerebellar Glutamate Chemical Exchange Saturation Transfer Alterations Correlated With Cognitive Impairment in Parkinson's Disease

ABSTRACT The role of cerebellar glutamatergic dysfunction in cognitive impairment of Parkinson's disease (PD) remains poorly understood. Glutamate chemical exchange saturation transfer (GluCEST) imaging enables noninvasive assessment of regional glutamate levels. To investigate t...

Development and Validation of a Plastic Surgery-Oriented Anatomical Scoring System for Surgical Indications in Vulvar Lichen Sclerosus

BACKGROUND: Vulvar lichen sclerosus is a chronic inflammatory condition that often leads to progressive anatomical distortion and functional impairment. For patients with advanced-stage disease, surgical intervention becomes a treatment option. However, a standardized tool to gui...

Whole-genome sequencing investigation of a neonatal intensive care unit outbreak involving colonization and infection Klebsiella grimontii ST566 and Klebsiella michiganensis ST35

The Klebsiella oxytoca complex (KoC) comprises opportunistic pathogens capable of causing outbreaks in neonatal intensive care units (NICUs). We investigated a NICU KoC outbreak involving colonized and infected preterm infant in the NICU of a Chinese tertiary hospital to characte...

A Novel Suture-Based Otoplasty Technique Combining Figure-of-Eight and Mattress Sutures for Prominent Ear Correction: A Retrospective Study of 89 Patients

BACKGROUND: Prominent ear is a common congenital deformity that can cause significant aesthetic and psychosocial concerns. This study introduces a novel suture-based otoplasty technique that combines figure-of-eight and mattress sutures to achieve natural-appearance aesthetic out...

Verrucous porokeratosis with prominent follicular involvement

The authors declare no conflicts of interest. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Development of a symptom cluster scale for breast cancer patients undergoing adjuvant chemotherapy based on the Chinese population: a Delphi-based study

Breast cancer is the most common malignancy among women in China.Postoperative adjuvant chemotherapy can reduce the risk of recurrence, but it can also give rise to complex symptom clusters that significantly affect patients’ quality of life and treatment adherence. Currently, sp...

Prognostic significance of positive peritoneal cytology in early-stage endometrial carcinoma after postoperative radiotherapy: a single-center retrospective cohort study

The prognostic significance of positive peritoneal cytology (PPC) in early-stage endometrial carcinoma (EC) remains controversial, particularly in the setting of contemporary adjuvant treatment. We aimed to evaluate the association of PPC with survival outcomes and recurrence pat...