Institution
Peking Union Medical College Hospital
Recent research
- Health & MedicineOpen access
LIG4 Syndrome Presenting with Extensive Cutaneous Viral Warts Caused by Multi-Type HPV Infection
Background: DNA Ligase 4 (LIG4) catalyzes the final ligation step during V(D)J recombination. Biallelic pathogenic variants in LIG4 cause severe combined immunodeficiency (SCID), a life-threatening immunodeficiency characterized by the lack of mature T and B cells. Case Presentat...
- Health & MedicineOpen access
Menopausal arthralgia and longitudinal changes in sex hormones and climacteric symptoms
Musculoskeletal discomfort (menopausal arthralgia) is the most prevalent and debilitating complaint during the menopausal transition. Despite its high prevalence, menopausal arthralgia has historically been overlooked, and establishing a direct association with menopause remains...
- Health & MedicineOpen access
Transcription factor binding to IGHM enhancer 3 (TFE3) break-apart fluorescence in situ hybridization (FISH) is the gold standard for the diagnosis of Xp11.2 translocation renal cell carcinoma (tRCC). However, FISH is costly and not accessible in all laboratories. We aimed to dev...
- Health & MedicineOpen access
Aligning Clinical Needs and AI Capabilities: A Survey on LLMs for Medical Reasoning
Abstract Large language models (LLMs) have emerged as important tools in healthcare, showing growing potential for clinical reasoning and patient care. This survey examines recent progress in medical LLMs, focusing on reasoning applications and requirements. We present a dual-vie...