Peking Union Medical College Hospital

Distinct Etiological and Clinical Patterns of Acute Mesenteric Ischemia at High Altitude: A Retrospective Comparative Study

Chen, Chen, Yang, Li, Xu, Fan, Xu, Zhijuan Liu, and Dong Wu. Distinct etiological and clinical patterns of acute mesenteric ischemia at high altitude: a retrospective comparative study. High Alt Med Biol. 00:00–00, 2026. Background: Acute mesenteric ischemia (AMI) is a life-threa...

Central Nervous System Vasculitis Mimicking Glioma in a Patient With Ulcerative Colitis: A Case Report and Literature Review

A patient with ulcerative colitis presented with progressive memory impairment and alexia, with brain imaging showing a mass-like lesion mimicking glioma. Histopathology confirmed central nervous system (CNS) vasculitis. The patient's memory and reading ability improved and final...

Accelerated Glofitamab as Urgent Bridging to CAR T‐Cell Therapy in High‐Risk Relapsed/Refractory Large B‐Cell Lymphoma

Conventional glofitamab step-up dosing reaches the 30-mg target dose approximately 3 weeks after obinutuzumab. This interval may be difficult to accommodate in patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) who require disease control within days before cel...

Genotype and phenotypic spectrum of pycnodysostosis: report of a case harboring two novel CTSK variants and literature review

Abstract Background Pycnodysostosis is an extremely rare inherited skeletal dysplasia with incidence of about 1 to 1.7 per million neonates. We reported a patient with pycnodysostosis, who had typical craniofacial deformity, short stature and recurrent limb fracture history. Lite...

First-in-human phase Ia study of the covalent TEAD palmitoylation inhibitor BPI-460372 in patients with advanced solid tumors: pharmacokinetics, exposure-limited dosing, and early antitumor activity

The Hippo pathway is a critical regulator of tumor development and progression, dysregulation of the Hippo pathway drives tumorigenesis in multiple malignancies. BPI-460,372 is a first‑in‑class covalent irreversible inhibitor of transcriptional enhanced associated domain (TEAD) p...

Delivery of cardiac rehabilitation through hybrid models and alternative settings by country income classification and decade: Comparisons from the International Council of Cardiovascular Prevention and Rehabilitation’s 2025 Global Audit Update

Objective Cardiac rehabilitation (CR) is an outpatient model of secondary prevention that improves patient outcomes, yet use remains limited. Hybrid/alternative CR addresses these challenges, but global availability, structure, and volumes have not been characterized since the pa...

Differential diagnosis of ovarian growing teratoma syndrome and immature teratomas after chemotherapy based on CT imaging

Abstract Background To differentiate ovarian growing teratoma syndrome (OGTS) from immature teratoma (IMT) based on semantic CT imaging features and provide an adjunct imaging tool to support preoperative assessment and treatment planning. Materials and methods Patients with path...

Smoking status and duration are associated with taxonomic and functional differences in the oral microbiome

Smoking is a major modifiable risk factor for human health and has been linked to alterations in the oral microbiome. However, how oral microbial composition and functional potential differ across smoking duration remains insufficiently characterized. This study aimed to evaluate...

Affibody-based approaches as potential therapeutics for breast cancer: mechanisms, applications, and future perspectives

Breast cancer presents a significant therapeutic challenge due to the substantial molecular and genetic diversity among its subtypes, thereby necessitating the development of refined intervention strategies. Macromolecular therapies, such as monoclonal antibodies, are often hinde...

Phase separation of PHLDB2 promotes lung adenocarcinoma progression through FLNA stabilization and ERK activation

Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer, but the phase separation-related mechanisms that support its progression remain poorly defined. By integrating phase separation-related gene profiling with prognostic modeling, we identified PHLDB2...

Dynamic cardio-renal-metabolic trajectories identify sepsis subphenotypes for individualized management: a cross-population cohort study

Sepsis heterogeneity remains a major barrier to precision medicine. Although cardio-renal-metabolic interactions critically influence outcomes, their dynamic evolution is rarely integrated into clinical phenotyping. We aimed to identify distinct sepsis subphenotypes based on dyna...

Frailty-Related Metabolic Signature in the Association Between Frailty and Coronary Artery Disease: Modification by Genetic Susceptibility

Background Frailty is associated with increased coronary artery disease (CAD) risk, but the circulating metabolic features underlying the frailty–CAD relationship and their interplay with genetic susceptibility remain unclear. This study aimed to identify a frailty-related metabo...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

A sequential screening strategy for inherited susceptibility genes in endometrial cancer

Abstract Objective Current screening strategies for hereditary endometrial cancer (EC) have limitations. This single-center study aimed to evaluate a novel sequential screening strategy for identifying hereditary EC in an unselected cohort. Methods All patients newly diagnosed wi...

Uterine corpus volume changes during definitive chemoradiotherapy for cervical cancer in pregnancy

Cervical cancer in pregnancy (CCIP) is rare, and evidence on definitive (chemo)radiotherapy is limited. Within our institutional CCIP cohort, we focused on the subset who received definitive concurrent chemoradiotherapy and, using weekly cone beam computed tomography (CBCT), char...

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

ABSTRACT Diabetic Foot Ulcer (DFU), a severe chronic diabetes complication with low healing and high recurrence rates, is a major global health challenge. Overexpression of matrix metalloproteinase‐9 (MMP‐9) and the consequent MMP‐9/TIMP1 (tissue inhibitor of metalloproteinase 1)...

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

ABSTRACT The accumulation of mutant huntingtin (mHTT) aggregates drives the pathology of Huntington's disease (HD), yet therapies capable of distinguishing toxic species from wild‐type proteins remain elusive. Here, a synthetic gene circuit, termed ARAA, was engineered to couple...

Calcium Hydroxylapatite in Facial Rejuvenation: A Review from Multi-Layered Aging Mechanisms to Material-Property-Guided Clinical Practice

Contemporary research on facial aging is undergoing a profound paradigm shift, transitioning from macroscopic descriptive phenotyping to refined cellular-molecular mechanistic dissection. This review reveals these frontiers across multi-omics and structural dimensions, highlighti...

Causal inference maps the sex-dimorphic genetic architecture and inflammatory-metabolic networks underpinning perceived aging in UK Biobank

Self-perceived facial aging is an externally observable aging-related phenotype that may reflect both biological and psychosocial dimensions of aging. However, its genetic and molecular determinants, sex-specific heterogeneity, and relationship with systemic aging-related pathway...