Palacký University Olomouc

Diagnostic pathways, healthcare utilization, and mortality in children and young people with early onset substance use disorders: a nationwide registry-based cohort study

Longitudinal, population-based evidence on the clinical profiles and mortality of youth with substance use disorders (SUDs) is limited, despite significant health and social risks. This study aimed to (1) characterize initial SUD diagnoses, demographic and healthcare profiles, an...

Preferential antiproliferative activity of an oleandrigenin-derived androstane toward prostate cancer cells

Abstract Cardiac glycosides, traditionally used for heart failure, are increasingly recognized for their anticancer potential. This study evaluated the in vitro antitumor activity of ten cardiac glycoside derivatives on androgen-insensitive (DU-145) and androgen-sensitive (LNCaP)...

Mapping point and line densities of cross-border governance: the example of the Interreg cooperation programme

Cross-border cooperation has become a key dimension of European integration, supported extensively through EU-Interreg programmes. Yet, the growing density of actors and interconnections creates methodological challenges for mapping and interpreting cross-border governance at the...

Ketogenic diet–induced changes in hepatic drug metabolism with potential implications for ozanimod pharmacokinetics in mice

Ketogenic diet (KD) is increasingly considered as an adjunctive therapeutic approach across a range of diseases, but its effects on the pharmacokinetics of concomitantly administered drugs remain unclear. Such interactions may be particularly relevant in multiple sclerosis, where...

Anti-methicillin-resistant Staphylococcus aureus (Anti-MRSA) flavonoids from Iraqi Citrus sinensis (L.) Osbeck

Citrus sinensis (L.) Osbeck (Rutaceae) was investigated as a potential source of anti-MRSA compounds. A bioassay-guided isolation approach afforded fourteen compounds from the peel and leaf extracts of C. sinensis , including a new flavanone glycoside, sinensidin ( 10 ). Structur...

Molecular Targets and Biological Activities of Carvone: An Evidence-Graded Review

Carvone is a naturally occurring monoterpene and the principal volatile constituent of spearmint (Mentha spicata) and caraway (Carum carvi), plants long used as carminative, digestive, antimicrobial, and flavoring agents. The compound exists as two enantiomers—S-(+)-carvone (pred...

PPGLomics: An Interactive Platform for Pheochromocytoma and Paraganglioma Transcriptomics

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors with unique biological behavior and remarkably high heritability, yet dedicated bioinformatics resources for these diagnoses remain limited. Existing cancer multi-omics platforms are pan-cancer in scope, oft...

The development and psychometric evaluation of the brief Compulsive Pornography Use Scale (CPUS-4)

Abstract Online pornography use has increased worldwide in recent decades, with problematic use being associated with negative mental health outcomes. However, no brief instrument is currently available to specifically assess Problematic Pornography Use (PPU) by operationalizing...

Clinicopathological Characteristics and Outcomes of Primary Parotid Gland Carcinomas in the Czech Republic: a Multicenter Retrospective Cohort Study of 453 Surgically Treated Patients

Parotid gland carcinomas are rare malignancies with marked histological and biological heterogeneity. Most published evidence is derived from single-center or selected institutional series, whereas comprehensive nationwide epidemiological data remain limited. The aim of this stud...

EUPopLink Country report - Slovakia

This article explores the intersection of populism and Euroscepticism within the Slovak political landscape, demonstrating how European issues have evolved from a largely depoliticised post-accession consensus to a pivotal domain of domestic political competition. The article foc...

Infrared absorption spectroscopy of a single polyatomic molecular ion

Abstract Absorption spectroscopy is a fundamental tool for probing molecular structure 1 . However, performing absorption spectroscopy on individual molecules is challenging because of the low signal-to-noise ratio 2,3 . Here we report on non-destructive absorption spectroscopy o...

Ajuga reptans L. from Romanian flora as a promising candidate for novel food applications

The increasing demand for natural ingredients with both functional and sensory properties has stimulated the exploration of underutilised plant species as potential sources for novel food applications. Ajuga reptans L. (Lamiaceae) remains relatively underexplored despite its phyt...

SPROUT: AI-based Seedling emergence PRedictiOn and trait extraction Using RGB Time-series

Article and Images used in the ML pipeline for the publication funded by TANGENC.

SPROUT: AI-based Seedling emergence PRedictiOn and trait extraction Using RGB Time-series

Article and Images used in the ML pipeline for the publication funded by TANGENC.

Timing of cognitive decline onset and life-course trajectories A pooled longitudinal analysis of 14,389 adults across three cohorts

Background Population ageing is driving a global surge in cognitive impairment. While late-life decline is well-characterized, the onset of measurable cognitive changes across the full adult lifespan remains uncertain. We aimed to estimate the age at which detectable decline begi...

Breaking Solvent Constraints Enables Sustainable Nanoscale Chemical Synthesis by Acoustic Droplet Ejection

This folder contains the Supporting Information–related raw and processed data associated with the publication: “Breaking Solvent Constraints Enables Sustainable Nanoscale Chemical Synthesis by Acoustic Droplet Ejection” The dataset provides full transparency and reproducibility...