Palacký University Olomouc

Practical continuous-variable quantum key distribution with squeezed light

Continuous-variable quantum key distribution (CV-QKD) has gathered significant interest for its potential to achieve high secret key rates and seamless integration with existing optical communication infrastructure. State-of-the-art CV-QKD systems primarily use coherent states fo...

DNA-encoded Ugi reactions in the organic phase: Lactam synthesis and use of cyclic ketones as scaffold-providing oxo-component

Isocyanide multicomponent reactions such as the Ugi fourcenter reaction are attractive for DNA-encoded library design because they allow for synthesizing diverse peptidomimetic and heterocyclic scaffolds from large numbers of simple and readily available starting materials. DNA a...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Oxygen Evolution Electrocatalysts with Trinuclear, Mixed‐Valence Iron Motifs on Electronically Aligned Carbon Dots

ABSTRACT The oxygen evolution reaction (OER), a bottleneck for water electrolysis, remains limited by the adsorbate scaling relations and sluggish interfacial electron transfer (IET). We address these challenges by anchoring mixed‐valence Fe 3+ /Fe 2+ motifs on aspartic‐acid–deri...

Multiple motor proteins regulate TDP-43 anterograde axonal transport

TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein essential for RNA metabolism. Under physiological conditions, it predominantly resides in the nucleus but is also expressed in the cytoplasm, where it regulates mRNA trafficking and local translation. In nearly 97% of...

Lateral sclerosis in amyotrophic lateral sclerosis is an upper motor neuron distal axonopathy (“dying back”): a clinical-neuropathological study

Abstract The hallmark neuropathological feature of upper motor neuron (UMN) degeneration in amyotrophic lateral sclerosis (ALS) is the “sclerosis” of the lateral corticospinal tract (CST)—the major axonal pathway connecting UMNs to lower motor neurons (LMNs). However, few studies...

Efficacy of Transdiagnostic Emotion‐Focused Therapy in the Treatment of Depression and Anxiety Symptoms: A Quasi‐Experimental Study

ABSTRACT Objectives This study is among the first to assess the efficacy of teletherapy‐delivered Transdiagnostic Emotion‐Focused Therapy (EFT‐T) for university students with depression and anxiety symptoms. Methods Therapy was offered in a 12–16 session format. Forty students wi...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

CEDAW, Digital Violence and State Due Diligence: Assessing India’s Response within a Global Framework

Abstract Online gender-based violence (OGBV) is escalating worldwide. This article argues that the Convention on the Elimination of All Forms of Discrimination against Women (CEDAW), read together with its General Recommendations, provides an operationalizable due diligence frame...

Prolonged low-dose intravenous thrombolysis in early recurrent stroke

INTRODUCTION: Treatment of acute ischemic stroke follows well-established guidelines and standards of care. However, the optimal management of ultra-early stroke recurrence remains unclear. We present outcomes of prolonged low-dose intravenous thrombolysis used as rescue therapy...

Nursing Students' Reports of Patient Safety Incidents and Reasons During Clinical Placements: A Secondary Analysis of the International Data

ABSTRACT Clinical placements expose nursing students to patient safety incidents and provide important opportunities for learning about safe care. This study explored how nursing students in four countries recognized and interpreted patient safety incidents encountered or witness...

Qubit-parity interference despite unknown interaction phases

Abstract Quantum interference between interacting systems is fundamental to basic science and quantum technology, but it typically requires precise control of the interaction phases of lasers or microwave generators. Can interference be observed if those interaction phases are st...

Lowering Coordination Symmetry as a Strategy for Tuning Slow Magnetic Relaxation in Quasi-Isotropic Mn(II) Systems

Abstract Two pentacoordinate Mn(II) complexes containing tridentate 2.2′-[oxybis(methylene)] bis(1H-1,3-benzimidazole) (OMeBB) ligand and pseudohalide coligands, [Mn(OMeBB)(NCS)2] (1) and [Mn(OMeBB)(NCO)2] (2), exhibit a very rare {MnIIN4O} coordination mode involving semicoordin...

Behavioural and contextual drivers of agri-environmental schemes adoption among large-scale farms in Czechia

Agriculture substantially contributes to environmental and climate change, with agri-environmental schemes (AES) often used to reduce the associated impacts. In the EU, they are publicly funded, voluntary and incentivised through financial payments, but they can encounter resista...

Monetary Valuation of Heritage Trees in Central European Cultural Landscapes

Heritage trees combine ecological importance with historical, symbolic, and commemorative meanings. We identified 81 culturally significant trees in four study areas in the Czech Republic and Slovakia and recorded their dendrometric characteristics, health, vitality, and cultural...

Multiobjective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance

Abstract Thrombolytic enzymes represent an important class of proteolytic biocatalysts for medical applications, yet currently used FDA-approved variants, including alteplase and tenecteplase, remain limited by suboptimal catalytic efficiency, off-target activity, and susceptibil...

Garden composters as refuges for myriapods: environmental factors shaping species distribution

Summary. Home composting has become an increasingly popular method for organic waste management; however, the invertebrate communities inhabiting garden compost remain poorly studied. The present study focused on myriapod (centipede and millipede) communities in 61 home composter...

Garden composters as refuges for myriapods: environmental factors shaping species distribution

Summary. Home composting has become an increasingly popular method for organic waste management; however, the invertebrate communities inhabiting garden compost remain poorly studied. The present study focused on myriapod (centipede and millipede) communities in 61 home composter...

Changes in self-reported smoking among university hospital employees over two decades: a repeated cross-sectional study

Abstract Background Smoking among hospital employees remains an important public and occupational health concern. Healthcare professionals are particularly relevant because of their role in smoking prevention and cessation. This study compared self-reported smoking prevalence amo...

Evidence of nitro-fatty acids in microscopic algae and cyanobacteria

Nitro-fatty acids (NO 2 FAs) are pleiotropic cell signalling modulators, playing a role in stress responses, development, and defence mechanisms in many organisms, including plants. However, to date their production in photosynthetic microorganism has not been studied. In this st...