Otto-von-Guericke-Universität Magdeburg

Context-dependent functional diversity of dorsomedial posterior parietal neurons revealed by single-unit fMRI mapping during naturalistic viewing

Abstract The dorsomedial posterior parietal cortex (dmPPC) plays an important role in episodic processing by integrating sensory, cognitive, and motor information across distributed brain systems. However, how individual dmPPC neurons participate in large-scale functional organiz...

NFDI4ING Fiona Summer School "Driving RDM": 0. Cover

NFDI4ING is the National Research Data Infrastructure for the Engineering Sciences. To educate Research Data Management (RDM), NFDI4ING's archetype Fiona conducts a summer school as practice-oriented training. Following the slogan "Driving RDM", a small-scale data-driven engineer...

Volumetric and functional connectivity alterations of the thalamus and thalamic nuclei groups in drug-resistant focal epilepsy: A 7T MRI study

Abstract Purpose Through its global and extensive connections with multiple brain structures, the thalamus can play an important role in seizure propagation. This study investigated volumetric and functional connectivity alterations of the thalamus and more specifically the thala...

Automated segmentation and length measurement of metacarpal and phalangeal bones for hand radiograph evaluation

Abstract Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurem...

Persisting Region‐Specific Microglia Activation and Synaptic Imbalance During Remission in a DSS ‐Induced Colitis Model

Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with neuropsychiatric comorbidities persisting even during clinical remission. While the dextran sulfate sodium (DSS) mouse model was previously applied to study gut-brain interactions, t...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Decoupling multistep schemes for elliptic–parabolic problems

We study the construction and convergence of decoupling multistep schemes of higher order using the backward differentiation formulae for an elliptic–parabolic problem, which includes multiple-network poroelasticity as a special case. These schemes were first introduced in [Altma...

Deep Learning-Based Temporal Gait Analysis Using a Smartphone IMU in Older Adults with and Without Non-Specific Low Back Pain

Accurate gait event detection using inertial measurement units (IMUs) is essential for temporal gait analysis, but frame-level detection is challenged by sparse initial contact (IC) and foot-off (FO) events. This study evaluated recurrent neural network architectures and training...

ReVita: home-based transcutaneous auricular vagus nerve stimulation for reducing pathological fatigue in chronic neurological and post-infectious conditions—study protocol for a randomized, double-blind, sham-controlled trial

Abstract Background Pathological fatigue is one of the most prevalent and disabling symptoms across chronic neurological, post-infectious, and inflammatory diseases, yet effective treatments remain limited. Transcutaneous auricular vagus nerve stimulation (taVNS) is a safe, non-i...

Subgroup variations in effectiveness of femoropopliteal sirolimus versus paclitaxel-coated balloon angioplasty: post hoc results of the randomised SIRONA trial

INTRODUCTION: The randomised SIRONA trial showed that sirolimus-coated balloon (SCB) angioplasty was non-inferior to paclitaxel-coated balloon angioplasty (PCB) regarding femoropopliteal primary patency. There was no difference in clinically driven target lesion revascularisation...

Characterisation and management of therapy-interrupting system errors associated with the use of the HomeChoice cycler for automated peritoneal dialysis

Abstract Background Methodological and technical education of nurses is required to address challenges of technology integration in peritoneal dialysis (PD). We analysed the nature of therapy interrupting system errors in automated peritoneal dialysis (APD) cyclers of a German PD...

Depressive symptoms in amyotrophic lateral sclerosis: associations with quality of life, disease progression and perceived social support—a German multicenter study

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease. Patients with ALS are at increased risk of developing depressive symptoms. A clearer understanding of the associations between depressive symptoms, disease progression, heal...

Advances and challenges in powder flowability and fluidization quality

Flowability and fluidization quality of bulk solids are closely interlinked and decisive for the processing behavior and homogeneity of product quality in many applications, ranging from fine chemicals to energy generation. In this perspective, we summarize recent advances in the...

Biomarkers of systemic disease burden and outcomes after transcatheter tricuspid edge-to-edge repair

Abstract Background Risk stratification after transcatheter tricuspid edge-to-edge repair (T-TEER) remains challenging, particularly in patients with advanced right-sided heart failure and systemic disease burden. Biomarkers reflecting inflammation, stress response and multiorgan...

Effect of Heating Tube Configuration on Hydrogen Production via Propane Steam Reforming: A Numerical Study

The hydrogen energy has received considerable attention in recent years due to escalating global concerns over climate change. Hydrogen production relies mainly on steam reforming, an endothermic process that requires external heat. Because of this, the rate of heat transfer with...

Comparison and Reliability of Inertial Sensor-Based Gait Data Acquisition Across Three Shank-Mounted Smartphone Configurations in Older Adults

About the Project This dataset was collected within the Spine Interactive project. The aim was to examine whether IMU time series recorded with three different smartphones are comparable during 2-minute treadmill walking trials in older adults. The devices were an iPhone 15 Pro,...