Otto-von-Guericke-Universität Magdeburg

TCR sensitivity shapes recognition of tumor antigen presented by host cells and TCR-T cell efficacy in solid tumors

Despite advances in adoptive T cell therapy, therapeutic efficacy in solid tumors remains inconsistent, and the mechanistic determinants of treatment failure are incompletely understood. Increasing evidence suggests that effective antitumor responses depend not only on direct rec...

Countering context effects in consumer decision-making: the limits of information-based debiasing approaches

Abstract The attraction and compromise effects describe preference shifts caused by adding an asymmetrically dominated or extreme alternative to choice sets. Despite the prominence of these context effects in consumer research, little is known about consumers’ coping behaviors in...

Intraoperative ventilation settings in Germany: an observational multicentre cross-sectional study

Intraoperative lung protective ventilation and, in inhalational anesthesia, minimal fresh gas flow (FGF) are recommended. It remains unclear how these recommendations are transferred to clinical routine. We aimed to assess corresponding anesthesia practices in Germany and raise a...

Hydrodynamics substantially affects induced structure formation in magnetic fluids

Magnetorheological fluids consist of micrometer-sized magnetic particles in a carrier liquid. Sufficiently strong external magnetic fields lead to the formation of string-like particle aggregates. We demonstrate that hydrodynamic interactions, that is, mutual couplings via induce...

Stall mitigation and performance enhancement in axial-flow air turbines using a hybrid passive–active flow control strategy

Harvesting maximum energy from axial turbines remains a significant challenge, particularly under stall conditions. Wells turbine, commonly used as self-rectifying axial turbine in wave energy conversion (WEC) systems, is limited by a narrow operating range, low power output, and...

Automated SSIM regression for detection and quantification of motion artefacts in brain MR images

Abstract Motion artefacts in magnetic resonance brain images can have a strong impact on diagnostic confidence. The assessment of MR image quality is fundamental before proceeding with the clinical diagnosis. Motion artefacts can alter the delineation of structures such as the br...

Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in a multiethnic US population

Abstract Neuroinflammation is associated with depression and anxiety risk, both of which demonstrate a bilateral relationship with cardiometabolic disorders. Systemic inflammation was also commonly described in patients with cardiometabolic disorders. It is, thus, unclear whether...

Different ties, different returns? Bonding and bridging social capital across mental health and academic transitions

Relationships are important higher-education resources, but different ties may have different longer-term returns. Using longitudinal data from the German National Educational Panel Study, we examine the functional specificity of bonding and bridging social capital. We test wheth...

Supporting AI Readiness Through Digital Workflows in Materials Science

Materials science produces heterogeneous data across experiments, simulations, and industrial processes that often remain bound to local formats, manual procedures, and project‐specific software. Digital workflows address this fragmentation through explicit, repeatable, and machi...

The QOLA study: psychometric validation of the Quality of Life of Parents of Children with Achondroplasia (QOLA) questionnaire - a multinational study in Germany, Italy, and Portugal

Abstract Background Parents of children with achondroplasia experience multidimensional impacts on quality of life (QoL), yet validated condition-specific instruments for assessing these outcomes across countries are scarce. This study evaluated the psychometric properties of the...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Partial Observation of Linear Systems With the Mori–Zwanzig Formalism

ABSTRACT The Mori–Zwanzig (MZ) formalism provides a systematic framework for deriving reduced‐order model of dynamical systems when only part of the state is observed, but its practical use is often limited by the complexity of the resulting computations. This paper develops an e...

On-demand therapies–emergency medication or daily routine?

Abstract Fluctuations represent a major therapeutic challenge in Parkinson’s disease (PD) and become increasingly prevalent with disease progression. While oral and device-aided therapies (DAT) improve symptom control, patients continue to experience disabling OFF episodes, in pa...

An efficient and cost-effective statistical voltage-based method for passive islanding detection in microgrids

Unintentional islanding is defined as the condition in which a section of the power grid continues to be energized by distributed generators after disconnection from the utility grid, for example, due to a fault. This situation remains a significant protection challenge in microg...

Coverage and adherence to the German childhood vaccination schedule: results from the KUNO-Kids health study

In Germany, the childhood vaccination schedule in 2015–2020 included 13 vaccines, for which primary immunization series was recommended to be completed by 24 months of age. Childhood vaccination coverage is monitored through health insurance claims data and pre-school entry exami...

Anisotropic Gas Permeability of Beech Wood from X-ray Microtomography and Pore Network Modeling: The Role of Vessels, Fibers, and Pyrolytic Conversion

Abstract Gas transport within biomass particles is a key factor controlling volatile release, secondary reactions, and product formation during pyrolysis. However, the influence of the anisotropic microstructure and its evolution during thermal conversion remains insufficiently u...

Scientific Competence in Undergraduate Medical Education: Professional Orientations of Physiology Educators

Introduction: Scientific Competence (SC) is a central objective in medical education, but its conceptualization remains insufficiently differentiated, particularly regarding the relationship between evidence use and participation in scientific knowledge generation. Objective: Thi...

Gender History: A Necessary Key to Understanding Central Europe

Abstract Seven specialists in Central and East Central European history have come together to discuss the state of the field of gender studies in their subfields. Much emphasis is placed on thinking about how the current political situation in the 2020s is affecting what historia...

Vacuum ultraviolet dielectric function of cubic InGaN for the entire composition range

The cubic zincblende polymorph of InGaN is a very promising candidate for optical applications. Its absence of spontaneous polarization fields in the (001) orientation and lower fundamental band gap compared to its wurtzite counterpart makes it especially interesting for efficien...

Coronary artery calcification score as a prognostic factor in patients undergoing allogeneic stem cell transplantation – a retrospective analysis

Abstract Background Coronary artery calcification (CAC) scoring can be measured as a by-product of computed tomography (CT). CAC scoring reflects the general cardiovascular risk profile of patients. The aim of the present study was to determine the prognostic role of CAC on overa...