Oslo University Hospital

Application of [ 18 F]NaF and [ 18 F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage

Objective Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study investigated the role of [ 18 F]-sodium fluoride ([ 18 F]NaF) and 2-[ 18 F]fluoro-2-deoxy-D-glucose ([ 18 F]FDG) PET/CT in evaluating of physiological molecular calcification...

Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials

BACKGROUND: Narcolepsy type 1 is characterized by excessive daytime sleepiness, cataplexy, disrupted sleep, sleep paralysis, and hypnagogic or hypnopompic hallucinations. Oveporexton (TAK-861), an oral orexin receptor 2-selective agonist, reduced symptoms of narcolepsy type 1 in...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Results from the Pan-European CIEMAR study: Local Tumour Control After Microwave Ablation of Colorectal Liver Metastases and Exploratory Associations with Ablation Margins and Confirmation Software

Abstract Purpose The CIRSE Emprint Microwave Ablation (MWA) Registry (CIEMAR) was designed to evaluate real-world effectiveness of MWA for colorectal liver metastases (CRLM). This analysis reports on local tumour control and includes post-hoc analyses of ablation margin size and...

Atrial cardiomyopathy and MRI-detected covert brain infarction in an elderly population-based cohort: the Akershus Cardiac Examination 1950 study

Abstract Introduction Atrial fibrillation is associated with both clinical stroke and covert brain infarction (CBI). Atrial cardiomyopathy has been proposed in absence of atrial fibrillation as an independent stroke risk factor, but supporting evidence is limited. This study aime...

Childhood inductive reasoning, cardiovascular and cardiometabolic morbidity and dementia risk – a population representative cohort study across six decades

Abstract Background Higher cognitive ability in late adolescence and young adulthood associate with reduced risk of dementia, but such assessments are influenced by educational selection. Whether specific cognitive abilities earlier in childhood associate with later dementia risk...

Interlocking plate compared with conventional pin fixation for undisplaced femoral neck fractures: a randomized controlled trial with radiostereometric analysis

Aims: In undisplaced femoral neck fractures, fixation failure remains a concern. In vitro studies suggest that interlocking plates increase torsional stability. However, whether this leads to clinically relevant improvement in fixation stability in vivo remains unclear. According...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

The paracrine Ephrin A4/BMP4 feed-forward loop sustains a tumor–CAF vicious cycle in osteosarcoma

Abstract Background Advanced osteosarcoma (OS) remains a clinical challenge due to its aggressive behavior and poor prognosis. Cancer-associated fibroblasts (CAFs) have been shown to contribute to tumor progression, but the tumor–CAF crosstalk in OS is still poorly defined. Eluci...

The SISAQOL-IMI glossary: harmonising terminology for patient-reported outcomes in cancer clinical trials

Abstract Background This study presents the development of a glossary designed to harmonize terminology, foster consensus and support the successful implementation of the Setting International Standards in Analysing Patient-Reported Outcomes and Quality of Life Endpoints in Cance...

Sex differences in dementia with Lewy bodies: a systematic review

Abstract Sex differences are increasingly recognized across neurodegenerative disorders, including Dementia with Lewy Bodies (DLB). Despite ongoing refinement of diagnostic criteria, DLB remains frequently misdiagnosed—particularly among females—reflecting gaps in our understandi...

Obstetric Factors Associated with Pelvic Floor Disorders and Surgery 30 Years After Childbirth: A Prospective Cohort Study

We aimed to compare symptoms of pelvic floor disorders (PFDs) and surgery risk by mode of delivery 30 years after first childbirth and assess symptom changes over time. We also examined associations between PFDs and pelvic floor muscle injuries. Prospective cohort study in 2024 o...

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

ABSTRACT Background There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challe...

Multi-modal learning with incomplete data

Multi-modal learning, in which diverse data types are integrated and analyzed together, has become a central area of research in artificial intelligence, driving major advances in a wide range of domains. However, in many practical situations, certain modalities or variables may...

The Psychopathology in Autism Checklist–Revised (PAC-R): Development and Validation

There are few appropriate screening tools for mental health in autistic people, particularly for individuals with co-occurring intellectual disabilities. A specially developed screening tool for this population, the Psychopathology in Autism Checklist (PAC), has shown acceptable...

Context-dependent localization and expression of glutamate and GABA and their machinery in microglia

Microglia are central regulators of brain homeostasis and synaptic architecture, but whether they, like astrocytes, act as reservoirs and handlers of glutamate and GABA is unknown. Using post-embedding immunogold electron microscopy, we provide the first ultrastructural evidence...

High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage

High grade serous ovarian cancer (HGSC) has low survival partly due to the lack of methods for detection, diagnosis, and risk prediction. TP53 mutations, which drive HGSC, are found in gynecological tissues as the result of somatic evolution, but it is unknown whether an excess o...

Classification of type 1 diabetes and type 2 diabetes based on administrative registry data: a nationwide study from Norway

Abstract Background Type 1 diabetes (T1D) and type 2 diabetes (T2D) differ in health care needs, and precise prevalence estimates by diabetes type are important for health care planning. Data and Methods Using Norwegian health registry data on diagnoses from primary and specialis...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

Abstract The adaptive immune receptor repertoire (AIRR) - the collection of an individual’s B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental exposures. Skewed repertoires have b...