Oslo University Hospital

No impact of parity on global gene expression levels in breast cancer tissue and normal breast tissue – a nested case-control study in the Norwegian Women and Cancer study

Abstract Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these changes are not observ...

Seasonal influences on DNA methylation at birth or at sampling time and their interaction with psychosis risk

Abstract Background Season at birth has been associated with increased risk for psychotic disorders. Epigenetic markers, which can be influenced by environmental exposures, may help to understand the mechanisms of seasonal effects. Aims To investigate two types of seasonal influe...

An integrated spatially defined roadmap of normal and cancer-associated colon fibroblasts

Abstract Cancer-associated fibroblasts (CAFs) promote tumorigenesis and represent potential therapeutic targets, highlighting the need for precise understanding of CAF heterogeneity. In colorectal cancer (CRC), CAF subsets and nomenclature vary widely, and many studies overlook t...

Prevalence of meeting aerobic physical activity and resistance training guidelines in advanced prostate cancer: a descriptive study of racial and regional disparities in the IRONMAN registry

Abstract Purpose To estimate guideline-based aerobic physical activity and resistance training participation in an international population of people with newly diagnosed metastatic hormone-sensitive or castration-resistant prostate cancer, and to assess racial and regional diffe...

Structural variants contribute substantially to complex trait heritability

Despite accumulating evidence that structural variants (SVs) exert disproportionate functional effects, their genome-wide contribution to complex trait heritability has not yet been systematically quantified. Here, we introduce MiXeR-SV, a tool that integrates long-read-derived S...

LARGE-SCALE PROTEOMICS REVEALS NEW CANDIDATE BIOMARKERS OF PREECLAMPSIA

Preeclampsia is one of the great obstetrical syndromes affecting approximately 5% of pregnancies worldwide. Arising from placental dysfunction, it remains a leading causes of maternal and fetal morbidity and mortality, and is associated with long-term cardiovascular, endothelial...

65. HIGHER POLY-METHYLATION SCORE FOR SCHIZOPHRENIA IS ASSOCIATED WITH GREATER NEGATIVE SYMPTOM SEVERITY AT 10-YEAR FOLLOW-UP

Background Negative symptoms are among the most disabling features of psychotic disorders and frequently persist over time. Baseline clinical measures (e.g. symptom severity at illness onset) explain only part of the variability in long-term outcomes, highlighting the need for im...

A GENOME WIDE ASSOCIATION ANALYSIS ON NITRENIUM-DERIVED CLOZAPINE METABOLITES – A STUDY WITH 306 SUBJECTS WITH KNOWN SMOKING STATUS

Background and aim Clozapine is the most effective antipsychotic for treatment of schizophrenia, yet its clinical use is limited by potentially life-threatening side effects including agranulocytosis and myocarditis. It has been suggested that bioactivation of clozapine to its re...

GPR35-positive mast cells are enriched in primary sclerosing cholangitis and show an enhanced secretory phenotype

OBJECTIVE: dependent mast cell biology relevant for cholangitis and biliary fibrosis. METHODS: knockdown were determined by DESeq2 and gene set enrichment analysis. Selected cytokines, TNFα and IL13, were measured by qRT-PCR and ELISA. Mast cell-cholangiocyte interaction was stud...

GENOME-WIDE ASSOCIATION STUDIES OF NON-RESPONSE TO ANTIDEPRESSANTS LEVERAGING HARMONIZED POPULATION-WIDE REAL-WORLD DATA FROM HEALTH REGISTRIES AND BIOBANKS

While recent genome-wide association studies (GWAS) have shown that antidepressant response has a genetic component, the robust identification of genetic associations in current studies is limited by insufficient sample sizes as well as variability in defining treatment-related p...

Exercise remodels the circulating extracellular particle proteome in men

Extracellular particles (EPs), including extracellular vesicles, are emerging mediators of inter-organ communication with growing relevance to cardiometabolic health. Whereas acute exercise mobilizes EV-associated proteins into the circulation, the plasma EP-enriched proteome res...

Does active surveillance prior to radical prostatectomy increase the risk of adverse pathological findings or postoperative prostate cancer treatment?

Active surveillance (AS) is an established management strategy for men with low- and favorable intermediate-risk prostate cancer (PCa). Nevertheless, a substantial proportion of patients ultimately undergo radical prostatectomy (RP), and the impact of prior AS on subsequent outco...

Combatting a Tobramycin-resistant Staphylococcus aureus outbreak in a neonatal intensive care unit: the impact of hygiene intervention and antibiotic substitution

Abstract Background Outbreaks of antibiotic-resistant bacteria in neonatal intensive care units (NICUs) is a significant risk to these vulnerable infants. This study describes a decade-long outbreak of tobramycin-resistant Staphylococcus aureus (TRSA) and the interventions implem...

Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation

Abstract Objective To quantify the survival benefit of deceased donor kidney transplantation versus continued dialysis according to patients’ characteristics (age, diabetes, cardiovascular disease), donor quality (standard criteria donor or expanded criteria donor) and donor retr...

Identifying drug‐resistant epilepsy using Swedish National Patient Registry data

Abstract Background Approximately 30% of individuals with epilepsy are drug‐resistant, suffering low quality of life and should be evaluated for other treatment modalities. Drug‐resistant epilepsy has no specific diagnostic code, making identification in national healthcare regis...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Gut microbiome signatures of colorectal cancer development are more pronounced in women compared to men in a population-based screening cohort

Abstract Background The gut microbiome has emerged as a promising source of biomarkers to enhance early detection of colorectal cancer (CRC). However, sex-specific differences in gut microbial profiles and their relationship to CRC risk remain underexplored. Our objective was to...

B7-H6 orchestrates oncogenic signaling and represents a therapeutic vulnerability in metastatic clear cell renal cell carcinoma

B7-H6 (NCR3LG1) is an immune checkpoint protein belonging to the B7 family of immunomodulatory proteins and serves as a ligand for the natural cytotoxicity triggering receptor NKp30 (NCR3) expressed on natural killer (NK) cells. In addition to its extracellular immunomodulatory d...

Toward Optimized Proteomics Analysis to Detect Bacterial and Host Proteins in Calcified Coronary Artery Plaques

Abstract Coronary calcification is the final stage in coronary heart disease, associated with significantly increased morbidity and mortality. The molecular pathology of calcification and especially events triggering calcification are poorly understood. Metagenomic and molecular...

Application of [ 18 F]NaF and [ 18 F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage

Objective Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study investigated the role of [ 18 F]-sodium fluoride ([ 18 F]NaF) and 2-[ 18 F]fluoro-2-deoxy-D-glucose ([ 18 F]FDG) PET/CT in evaluating of physiological molecular calcification...