Oslo University Hospital

Comparison of CT-based migration analysis against radiostereometric analysis for assessing two-year migration in an uncemented medial pivot tibial knee implant

Aims: Radiostereometric analysis (RSA) is the gold standard for migration analysis of orthopaedic implants, but CT-based RSA has shown comparable results in an increasing number of joints. In this study, we compared the method in an uncemented medial pivot tibial implant. Our pri...

N1-Methylpseudouridine-Modified mRNA-Transfected Dendritic Cells Enable Efficient Generation of Functional Tumor Antigen-Specific Cytotoxic T Lymphocytes

Efficient generation of tumor-specific cytotoxic T lymphocytes (CTLs) remains challenging. Although mRNA-based approaches enable the delivery and expression of diverse tumor-specific antigens, unmodified mRNA can trigger innate immune responses that suppress translation. Here, we...

Feasibility and acceptability of including advance care planning in a home-based palliative-care coordination meeting: a longitudinal ethnographic study of the experiences of older patients, their relatives and healthcare professionals

Abstract Background Advance care planning provides a structured approach to conversations about values and preferences but is uncommon in clinical practice. We implemented advance care planning as routine at the initiation of an individually tailored palliative care pathway in No...

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Sociodemographic, Criminological and Clinical Determinants in Suicide After Release From Prison: A 23‐Year National Cohort Study

ABSTRACT Background Suicide risk is elevated after prison release, but population‐level evidence on temporal risk patterns and associated factors remains limited. We aimed to describe characteristics of individuals who die by suicide after release from Norwegian prisons, compare...

Zonation Hallmarks in Human PSC‐Derived Hepatic Organoids Integrated into an Immune‐Compatible Organ‐on‐Chip for Liver Injury Modeling

ABSTRACT Liver metabolic zonation enables hepatocytes to carry out diverse, spatially organized functions essential for liver homeostasis and metabolism. However, in vitro recapitulation of zone‐specific diversity, particularly in human pluripotent stem cell (PSC)‐derived hepatoc...

Low‐level light therapy for dry eye disease and meibomian gland dysfunction: A systematic review and meta‐analysis

Abstract A healthy tear film is vital for ocular surface integrity and relies on the coordinated function of the lacrimal glands, meibomian glands and conjunctival goblet cells. Dysfunction in any of these elements can lead to dry eye disease (DED). This systematic review and met...

A phosphoinositide and RAB switch controls early macropinocytosis

Macropinocytosis is a non-selective endocytic process by which cells take up large amounts of extracellular fluid into giant vesicles known as macropinosomes. This mechanism is used by immune cells to sample the surroundings for antigens and can be exploited by cancer cells for n...

Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease

Importance Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential disease-modifying therapy for Parkinson disease based on preclinical and early studies. Whether prolonged oral nicotinamide riboside improves clinical outcomes in Par...

Analysis of circulatory extracellular vesicle–associated cytokines as candidate disease-associated markers in ER-positive breast cancer

Abstract Introduction Cytokines are signaling molecules produced by various cell types, including immune cells, and play important roles in tumor development and progression. Extracellular vesicles (EVs) are small membrane-bound particles secreted by all cell types, including can...

Combining TAG ‐ 72CAR with anti‐ MUC16CAR improves the potency of ovarian cancer treatment

Ovarian cancer (OC) is typically associated with poor prognosis and high mortality. Chimeric antigen receptor (CAR) T‐cell therapy offers a promising strategy, yet its application in solid tumours remains constrained by limited efficacy and on‐target/off‐tumour toxicities. We pre...

Preventable in-hospital deaths due to adverse events: a retrospective case record review study

Abstract Background There is no single parameter that describes the level of patient safety in hospitals. Among options, retrospective case record review (RCRR) is an established method for analysing in-hospital deaths to determine the percentage that were preventable. The assess...

The rate of total hip arthroplasty after closed reduction of late-detected hip dislocation

Aims The outcome of late-detected developmental dysplasia and dislocation of the hip (DDH) deteriorates with the length of follow-up. The aims of this study were to explore the rate of total hip arthroplasty (THA) with follow-up to patient age 60 to 76 years, and to define risk f...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Insensitivity to skin pain, tickling, and spicy food in a woman with a pathogenic NAA10 variant: a case report

Abstract Background The NAA10 gene on the X chromosome encodes NAA10, the catalytic subunit of the N-terminal acetyltransferase complex NatA, which co-translationally acetylates nearly half the human proteome. From the variety of NAA10 substrates, one would surmise that the pheno...

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

No impact of parity on global gene expression levels in breast cancer tissue and normal breast tissue – a nested case-control study in the Norwegian Women and Cancer study

Abstract Background We have previously demonstrated that the linear decrease in postmenopausal breast cancer incidence with increasing parity is linked to expression changes in hundreds of genes in the peripheral blood cells of healthy women. However, these changes are not observ...