Oslo University Hospital

OA03-RF01.05. The Safety and Efficacy of Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma in Scandinavia (SEES-Study)

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Endoscopic submucosal dissection (ESD) is recommended for early-stage esophageal squamous cell carcinoma (ESCC). Most data on the efficacy of ESD for ESCC comes...

Epigenetic ageing is accelerated in drug-resistant epilepsy and dynamically modulated during ketogenic diet therapy

Background The ketogenic diet (KD) is an established treatment for drug-resistant epilepsy. Beyond seizure reduction, many patients report improved energy, cognition, and well-being. DNA methylation (DNAm)–based epigenetic clocks provide molecular indices of biological ageing and...

In vivo quantification of polyethylene wear in total ankle arthroplasty

Aims In vivo assessment of polyethylene (PE) wear in total ankle arthroplasty (TAA) relies on approximation using 2D metal interspace height (2D-MIH) loss on weightbearing radiographs. Weightbearing CT (WBCT), combined with distance mapping, may improve quantification of PE wear...

Calcium handling in post-infarction arrhythmias - evidence from large animals

Understanding the causes of ventricular arrhythmias after myocardial infarction (MI) remains a major challenge to academic and clinical medicine. Key concepts in the pathophysiology underlying such events are based on studies in rodents, in whom altered sarcoplasmic reticulum (SR...

EngineeredNatural Killer Cell Derived-ExtracellularVesicles: An Acellular Immunotherapy with Cytotoxic Effects in SNU-1079Human Cholangiocarcinoma Cells

Abstract The use of natural killer (NK) cells for the treatment of solid tumors such as cholangiocarcinoma has been hindered by challenges related to cell production, persistence and trafficking, as well as by reduced efficacy within an immunosuppressive tumor microenvironment. A...

Adolescents at the crossroads: genetic associations between psychotic symptoms and antisocial traits

<title>Abstract</title> Antisocial behaviour in youth has serious consequences at individual and societal level. Adolescence is also a critical period for the emergence of prodromal psychosis symptoms. Their co-occurrence may aggravate aggression and lead to severe adverse outcom...

Voice metrics and workload in helicopter rescue: insights from ninety-six cockpit recordings

The relationship between subjective workload and task performance is multifaceted. In aviation research, task performance is typically evaluated using multiple variables. Voice metrics can provide valuable insights regarding operational improvements and offer objective assessment...

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Liver Transplantation for Nonresectable Colorectal Liver Metastases

OBJECTIVE: To determine if stringent selection criteria could result long-term overall survival and to determine the proportion of patients that most likely were cured by the transplantation. SUMMARY BACKGROUND DATA: Liver transplantation is a potentially curative option for pati...

No Differences in Blood Pressure or Anthropometric Measures in 3‐Year‐Old Children After a Randomized Mediterranean Dietary Intervention During Pregnancy in Norway

AIM: The randomized controlled Cardiovascular Risk Reduction Diet in Pregnancy (CARRDIP) study demonstrated that a Mediterranean diet during pregnancy could alter maternal lipid levels, improve fetoplacental perfusion, and reduce preterm delivery rate. Here, we examine whether th...

Spatial organization of the tumor-immune microenvironment in ER-positive breast cancer with treatment remodeling and associated clinical responses

The tumor microenvironment influences treatment response in ER-positive breast cancer, but what distinguishes responders from non-responders and how it changes during treatment is poorly understood. Here, we profiled ER-positive breast tumors treated with neoadjuvant chemotherapy...

Patients’ experiences of living with the risk of Alzheimer’s disease – a multicentre qualitative study

Aims and objectives To explore the experiences of receiving and living with a diagnosis of prodromal Alzheimer’s disease. Background Alzheimer’s disease is a progressive dementia disorder, with pathology potentially developing years before clinical symptoms. Evidence concerning p...

Quantitative biochemical profiling of GCase activity and α-synuclein proteoforms in post-mortem human brains from GBA-related and idiopathic Parkinson’s disease

Variants in GBA1 , encoding lysosomal glucocerebrosidase (GCase), are risk factors for Parkinson’s disease (PD), which is characterized by α-synuclein (αSyn) accumulation and lysosomal dysfunction. Nonetheless, the relationship between αSyn accumulation and GCase deficiency remai...

Cardiovascular and cognitive consequences of steep head-down tilt in awake older men

This study investigated cerebral hemodynamics, intracranial pressure, and cognitive function in eighteen older men (median 72 years, IQR 68-75, 94% with ≥1 comorbidity) during a 15-minute 30-degree head-down tilt (HDT). Participants were monitored with continuous non-invasive hem...

Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...