NYU Langone Health

Iatrogenic portobiliary fistula treated with covered stent following percutaneous transhepatic biliary drainage

Percutaneous transhepatic biliary drainage (PTBD) is a common interventional radiology (IR) procedure typically used in the treatment of biliary obstruction when an endoscopic approach has failed or is not technically feasible. PTBD has a low overall complication rate with the So...

Spatial mixed models for assessing environmental exposure effects on the microbiome

Environmental exposures such as air pollution may influence human health partly through microbiome, but statistical modeling is challenged by spatial dependence across regions and ecological correlations among taxa. We propose SpaMixed, a novel spatial mixed modeling framework fo...

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the as...

Intraprosthetic dislocation in modular dual-mobility: does the company matter? A systematic review and meta-analysis

INTRODUCTION: Intraprosthetic dislocation (IPD) is a rare but potentially catastrophic complication of dual-mobility (DM) implants, defined by dissociation of the inner femoral head from the polyethylene liner. Modular dual-mobility (MDM) designs were introduced to improve intrao...

Associations between social determinants of health and clinical diagnosis time of uterine fibroids and endometriosis: a cross-sectional electronic health record-based study

This study characterizes the association between self-reported race/ethnicity, insurance type, and preferred language with clinical diagnosis time for uterine fibroids (UF) and endometriosis patients, defined as time from first symptom consultation to diagnosis date. We extracted...

Long-term Survivorship of Transfibular Trabecular Metal Total Ankle Arthroplasty: 10-Year Minimum Clinical and Radiographic Follow-up

BACKGROUND: Total ankle arthroplasty (TAA) utilization has rapidly increased over the last decade despite relatively unknown long-term survivorship of fourth-generation implants. The purpose of this study was to determine the long-term survivorship of the trabecular metal (TM) tr...

BUB1B Mitotic Kinase Dependency Reveals CENP-E Inhibition as a Tractable Approach for Castration and Enzalutamide Resistant Prostate Cancer

Abstract Castration-resistant prostate cancer (CRPC) progression despite treatment with potent androgen receptor (AR) antagonists such as enzalutamide is a major clinical challenge. The mitotic kinase BUB1B is a central member of an oncogenic seven-gene network that drives CRPC....

Early Changes in Kidney Transplantation following Implementation of the Increasing Organ Transplant Access Model

Background: The Increasing Organ Transplant Access (IOTA) model is a mandatory experimental payment model that aims to improve kidney transplant access using financial incentives and penalties for transplant centers randomized to model participation, based primarily on growth in...

Genotype-driven tumor ecosystems drive immune evasion and immunotherapy resistance in melanoma

Genetic and transcriptional alterations in cancer cells shape their interactions with immune and stromal compartments, thereby influencing tumor progression, immune evasion, and response to immune checkpoint inhibitors (ICIs). Yet, how these interactions are spatially organized w...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Mobile Cardiac Rehabilitation for Older Adults With Ischemic Heart Disease: A 12‐Month Follow‐Up on Hospital Readmissions in the RESILIENT Trial

Kaplan-Meier analysis of time to first all-cause readmission over 12 months among older adults with ischemic heart disease randomized to 3 months of mobile health cardiac rehabilitation (mHealth-CR) or usual care. There was no significant difference in time to first readmission b...

Impact of hormone therapy on mood in a real-world clinical setting: a retrospective observational study

Objective: Mood disturbances—including depressed mood, irritability, anxiety, and mental exhaustion—are common during the menopause transition, affecting up to 68% of women. While menopausal hormone therapy (HT) is FDA-approved for vasomotor and genitourinary symptoms, its role i...

Review of Hypoxemia Quantification Methods for Assessing the Severity of Obstructive Sleep Apnea

Abstract Purpose of Review Obstructive sleep apnea (OSA) is a common nocturnal breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to sleep fragmentation and intermittent hypoxemia. The apnea-hypopnea index (AHI) is the most widely used cl...

Neoadjuvant PD1 plus CTLA-4 immune checkpoint blockade in surgically resectable recurrent glioblastoma: a randomized surgical window-of-opportunity trial

Abstract We conducted a randomized surgical window-of-opportunity trial ( NCT04606316 ) in recurrent, resectable glioblastoma. Between 2021 and 2024, 71 patients were screened, and 63 were randomized (intention-to-treat [ITT] population), and 58 received study treatment. Patients...

Global variability in cardiovascular care of pediatric cancer patients and survivors: survey results from the International Cardio Oncology Society (ICOS)

Childhood cancer survivors (CCS) are at elevated risk for cardiovascular disease due to cardiotoxic cancer therapies. Different international guidelines and recommendations for follow-up were published. However, global practices surrounding cardiovascular risk assessment, screeni...

Evaluating the geographic distribution of rural PFAS contamination and potential dietary sources of exposure

Abstract Aside from specific occupational exposures, ingestion is believed to be the primary route of exposure to PFAS, a class of forever chemicals known for their ability to repel oil and water, reduce friction, and resist high temperatures. The goal was to explore the geograph...

Dietary Fat Intake and Mortality Among Patients With Nonmetastatic Prostate Cancer

Importance There are 3.5 million prostate cancer survivors in the US, with a need for evidence-based lifestyle recommendations that improve survivorship. Objective To assess whether consumption of specific dietary fats after diagnosis is associated with long-term survival among p...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...