Nuffield Orthopaedic Centre

Knotless Suture Repair For Chronic Lateral Ankle Instability: A Systematic Review and Single-Arm Meta-Analysis

Introduction There is a need to assess the use of knotless sutures in cohorts with chronic ankle instability (CAI). Methods A literature search of Embase, Ovid MEDLINE, Cochrane Library and Scopus was conducted from each database’s inception to August 15, 2025. Eligible studies r...

ORTHOPAEDIC TRAUMA IN NORTHERN MALAWI'S CENTRAL HOSPITAL: INJURY PATTERNS, OPERATIVE NEED, AND SERVICE CONSTRAINTS

Malawi has a high burden of traumatic injury but limited orthopaedic surgical capacity, particularly in the northern region where a single orthopaedic surgeon serves a population of over four million. This study aimed to describe the epidemiology of orthopaedic trauma in northern...

Validation of the European Bone & Joint Infection Society recommendations for debridement, antibiotics, and implant retention in hip and knee periprosthetic joint infection

Aims The aim of this study was to externally validate the European Bone & Joint Infection Society (EBJIS) recommendations for the use of debridement, antibiotics, and implant retention (DAIR) in the treatment of periprosthetic joint infection (PJI), examining the independent asso...

Early national comparison of robotic versus conventional hip replacements for arthritis using National Joint Registry data: target trial emulation study

Abstract Objectives To evaluate the early comparative effectiveness of robotic versus conventional total hip replacement (THR) in the UK. Design Target trial emulation study. Setting Public and private hospitals using data from the National Joint Registry of England, Wales, North...

Test-retest reliability of plasma biomarkers and digital cognitive metrics at clinically meaningful timescales

Abstract Background Digital cognitive testing and plasma biomarkers have emerged as key players for population screening and measuring drug efficacy in clinical trials for Alzheimer’s Disease (AD). Understanding test-retest reliability of these tools is essential to estimate mean...

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, in...

Effect Modification of Rescue Stenting in ICAS-Related Middle Cerebral Artery Occlusion: The Role of Thrombectomy Failure, Stenosis Severity, and ASPECTS

Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the as...

Multifactorial and multiple component interventions for preventing falls in older people living in the community

RATIONALE: Multifactorial fall prevention interventions are those where intervention components are tailored to each person's individual fall risk factor profile. Multiple component interventions provide the same components to everyone. The evidence on the effects of these interv...

A systematic review and individual patient data meta-analysis to determine the effect of primaquine dose on efficacy, tolerability and safety in uncomplicated Plasmodium vivax malaria in Latin America

Background Primaquine is widely used to prevent relapses of Plasmodium vivax malaria, but the optimal dose in Latin America is unknown. We undertook a systematic review and individual patient data meta-analysis to investigate the efficacy, tolerability and safety of different pri...

Comparison of current treatment strategies for AMD-related submacular haemorrhage: Real-world outcomes

Abstract Purpose Comparison of available treatment modalities for neovascular AMD-related submacular haemorrhage including robot-assisted subretinal drug delivery. Methods Single centre, long-term, retrospective analysis of patients treated for nAMD-related submacular haemorrhage...

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

Abstract Urinary tract infection (UTI) remains a major global health burden, with frequent recurrences and rising antimicrobial resistance compromising treatment efficacy. Conventional susceptibility assays often fail to predict clinical outcomes, highlighting the need for more p...

Patient, surgeon, and institutional variation in dual-mobility component use in primary total hip arthroplasty

Aims The aim of this study was to quantify the contribution of patient-, surgeon-, and institution-level factors to variation in dual-mobility component use in primary total hip arthroplasty (DM-THA) in England. We sought to determine whether current patterns reflect appropriate...

HPV DNA negativity following AHCC or nonavalent vaccination or their combination in women with persistent HPV infection without HSIL

Persistent infection with high-risk human papillomavirus (HR-HPV) is a common clinical condition for which no validated systemic antiviral therapy is currently available, and in the absence of high-grade cervical lesions management is generally limited to surveillance. Active Hex...

Osteotomies around the knee are associated with low short‐term adverse event and reoperation rates: A 25‐year national Hospital Episode Statistics analysis in England

Abstract Purpose Osteotomy around the knee (OAK) is an established joint‐preserving procedure. We sought to use large‐scale registry data to examine the short‐term reoperation and adverse outcome rates after OAK. Methods Data on high tibial osteotomy (HTO) and distal femoral oste...

Approaches to sharing trial results with adult patients and the public: a qualitative interview and focus group study

<title>Abstract</title> Background Sharing trial results with participants is increasingly recognised as an ethical obligation that fosters trust, respect, and engagement. Yet in practice, results are rarely shared. Researchers often lack guidance on what information to include o...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Challenges and barriers to musculoskeletal injury research in sub-Saharan Africa

Aims: Musculoskeletal (MSK) injuries are a major cause of morbidity and mortality worldwide. However, research into MSK injuries is hampered by significant challenges and barriers, particularly in low-and middle-income countries (LMICs). Our aim was to identify the most important...

The importance of B cells for osteogenic homeostasis

Abstract Therapeutic interventions for diseases such as leukemia and autoimmune disorders are increasingly designed to selectively target and deplete specific immune cell subsets over prolonged periods. This can disrupt the homeostasis of the adaptive immune system, with conseque...

Neurodevelopmental and neurological features in children with hypochondroplasia

Abstract Aim To assess neurodevelopmental and neurological features, including neuroimaging abnormalities, in children with molecularly confirmed hypochondroplasia. Method A retrospective cohort study of children with molecularly confirmed hypochondroplasia seen at Evelina London...

Risk factors for scaphoid nonunion in acute fractures treated with cast immobilization

Aims: There is a lack of published evidence relating to the risk factors for nonunion seen in acute scaphoid fractures. We aimed to describe the risk factors for nonunion in adult patients (aged ≥ 16 years) treated with cast immobilization for acute scaphoid fractures. Methods: W...