Nuffield Orthopaedic Centre

Approaches to sharing trial results with adult patients and the public: a qualitative interview and focus group study

<title>Abstract</title> Background Sharing trial results with participants is increasingly recognised as an ethical obligation that fosters trust, respect, and engagement. Yet in practice, results are rarely shared. Researchers often lack guidance on what information to include o...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Challenges and barriers to musculoskeletal injury research in sub-Saharan Africa

Aims: Musculoskeletal (MSK) injuries are a major cause of morbidity and mortality worldwide. However, research into MSK injuries is hampered by significant challenges and barriers, particularly in low-and middle-income countries (LMICs). Our aim was to identify the most important...

The importance of B cells for osteogenic homeostasis

Abstract Therapeutic interventions for diseases such as leukemia and autoimmune disorders are increasingly designed to selectively target and deplete specific immune cell subsets over prolonged periods. This can disrupt the homeostasis of the adaptive immune system, with conseque...

Neurodevelopmental and neurological features in children with hypochondroplasia

Abstract Aim To assess neurodevelopmental and neurological features, including neuroimaging abnormalities, in children with molecularly confirmed hypochondroplasia. Method A retrospective cohort study of children with molecularly confirmed hypochondroplasia seen at Evelina London...

Risk factors for scaphoid nonunion in acute fractures treated with cast immobilization

Aims: There is a lack of published evidence relating to the risk factors for nonunion seen in acute scaphoid fractures. We aimed to describe the risk factors for nonunion in adult patients (aged ≥ 16 years) treated with cast immobilization for acute scaphoid fractures. Methods: W...

Glucagon-like peptide-1 receptor agonists are associated with improved 90-day outcomes after total hip and knee arthroplasty

Aims Obesity and diabetes are risk factors for developing osteoarthritis and associated with worse outcomes following total hip (THA) and total knee arthroplasty (TKA). Glucagon-like peptide-1 receptor agonists (GLP-1as) improve glycaemic control and promote weight loss. The aim...

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...