Northwell Health

Cardiac Myosin-Binding Protein C in Cardiovascular Disease

Cardiac myosin-binding protein C (cMyBPC) is an important sarcomeric regulatory protein that plays a key role in myocardial contraction and relaxation. Through its interactions with thick and thin filament proteins, cMyBPC helps regulate cross-bridge cycling and contributes signi...

Pharmacokinetics of phosphodiesterase type 5 inhibitors and β-adrenergic receptor type 3 agonists for benign prostatic hyperplasia

Introduction Benign prostatic hyperplasia (BPH) is amongst the most common conditions affecting aging men, with resulting lower urinary tract symptoms (LUTS) impeding on quality of life. While many medication classes exist for treatment of LUTS secondary to BPH, their increasing...

Liver Disease, Liver Fibrosis, and the Invasive-Management Gap in Acute Myocardial Infarction: A Single-Center Cohort with Dual ICD and FIB-4 Stratification

Patients with chronic liver disease are systematically excluded from acute myocardial infarction (AMI) trials, and prior real-world data rely on administrative coding alone. Whether ICD-coded liver disease and laboratory-defined liver fibrosis identify the same patients, and whet...

Loss of M1 acetylcholine receptor-mediated orexinergic activity contributes to immune dysfunction in experimental sepsis

<title>Abstract</title> <italic>Background</italic>: Sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection) causes millions of deaths worldwide annually. Sepsis-induced changes in brain regulatory functions remain understudied. Previous wo...

State-of-Art on Multidisciplinary Approaches to Meningioma: A Systematic Review of the Available Evidence

Background: Meningiomas are the most common primary intracranial tumors, often requiring complex management due to their proximity to critical neurovascular and orbital structures. While surgery remains the cornerstone of treatment, achieving optimal outcomes requires coordinated...

A quality improvement initiative to optimize diagnostic and antimicrobial stewardship of ventilator-associated tracheitis in the pediatric intensive care unit

OBJECTIVE: To reduce frequency of endotracheal aspirate culture (EAC) collection and decrease antibiotic days of therapy (DOT) for ventilator-associated tracheitis (VAT). DESIGN: Quality improvement intervention. SETTING: Tertiary-care pediatric intensive care unit (PICU). PATIEN...

Identification of robust speech-based markers of negative symptom severity in schizophrenia spectrum disorders

There is growing interest in using digital health technologies to overcome limitations of traditional negative symptom assessment in schizophrenia spectrum disorders (SSD). For example, computerized speech analysis has been used to quantify speech and language changes associated...

Weight Management Before Pregnancy to Reduce Cardiovascular Risk

Cardiovascular disease remains the leading cause of morbidity and mortality among women globally, with growing evidence suggesting that cardiovascular risk can begin developing well before pregnancy, even during the preconception period. Among the most significant contributing fa...

Peripheral Nerve Entrapment Mimics of Overuse Syndromes

Repetitive use injuries are commonly seen by musculoskeletal providers, usually in the form of tendinopathies. However, focal peripheral nerve entrapment can mimic or coexist with tendon pathology, particularly when weakness, sensory symptoms, or imaging findings are subtle or no...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Why Do Residents Pursue Fellowship Training in Geriatric Medicine?

ABSTRACT Background Despite the important role of Geriatricians in our society, there is a shortage of Geriatric Medicine specialists. This study surveyed fellows enrolled in ACGME approved Geriatric Medicine fellowships in the United States for insight into why they joined a Ger...

A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials

Clozapine was (1) first introduced in Austria and Switzerland in 1972, (2) associated with 8 Finnish deaths due to agranulocytosis in 1975 (almost leading to its withdrawal), and (3) approved in the United States (US) for treatment-resistant schizophrenia in 1989 (resulting in a...