Northwell Health

Artificial Intelligence for Cardiac Ischemia Detection: A Review of Biosensor, Biomarker, and Imaging Applications

Ischemic heart disease is the leading cause of global mortality, yet accurate and timely detection remains constrained by incomplete signal capture, noise, operator dependence, and imperfect reference standards. Artificial intelligence (AI) may enhance cardiovascular sensing by e...

Surgical and Radiographic Outcomes in Cervical Deformity Patients with High T1 Slope and High C2 Slope (HTHC) Versus Low T1 Slope and High C2 Slope (LTHC)

Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

From Classification to Cross-Modal Understanding: Leveraging Vision- Language Models for Fine-Grained Renal Pathology

Fine-grained glomerular subtyping is essential for kidney biopsy interpretation, yet it presents a harder setting than the broad organ- or disease-level recognition tasks commonly used in vision-language model (VLM) evaluation. In this task, all categories arise within the same r...

Exploring provider preferences for HIV treatment support packages integrating long-acting injectable antiretroviral therapy in New York Ryan White Part A medical case management programs

Background: Understanding the preferences of core HIV medical case management (MCM) program staff for long-acting injectable antiretroviral therapy (LAI ART)-related support services could help integrate those services into MCM programs, thus facilitating uptake of LAI ART and in...

PET/CT-first staging in anal cancer: reconsidering the role of routine MRI

Multimodal imaging with pelvic MRI and FDG PET/CT is currently recommended for staging anal squamous cell carcinoma (ASCC). However, accumulating data suggest that PET/CT frequently alters staging and radiotherapy planning, raising questions about whether routine MRI is necessary...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Anatomical and Histologic Response to Neoadjuvant Therapy: Recurrence Patterns Among Poor Responders. A Multi-institutional Observational Cohort Study.

OBJECTIVE: To characterize the prognostic implications after hepatectomy for colorectal liver metastases (CRLM) by integrating anatomical response to neoadjuvant therapy (NAT), quantified using the Tumor Burden Score ratio (TBSr), with histologic response assessed by Tumor Regres...

Increasing Utilization, Rising Facility Charges, and Evolving Procedure Mix in Hip Arthroscopy at United States Hospital‐Based Ambulatory Surgical Centers From 2016 to 2022

Purpose To evaluate national trends in hip arthroscopy utilization and procedure mix, assess adjusted total costs by subtype, and examine regional and payer variation in case distribution among hospital‐based ambulatory surgical centers (ASCs) from 2016 to 2022. Methods Using the...

PREDICTION, SELECTION, AND STIGMA: ETHICAL TENSIONS IN PSYCHIATRIC GENETICS

Overall Abstract Within the past year, the field of psychiatric genetics has continued to advance innovative efforts to understand and improve public health. Several areas raise complex ethical issues, including research on pediatric neurodivergence and neurodiverse populations,...

Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis

Study Design Systematic Review. Objectives The objective of this study was to answer two questions: (1) Did the overall survival (OS) of patients with spinal metastatic renal cell carcinoma (mRCC) improve in publications from 2017 and afterwards compared to 2016 and before? (2) D...

TOTAL KNEE ARTHROPLASTY IN NONAGENARIANS: A COMBINED RETROSPECTIVE REVIEW FROM TWO HEALTHCARE SYSTEMS

Introduction Total knee arthroplasty (TKA) is an effective and durable operation for the management of end-stage osteoarthritis. The American Joint Replacement Registry reports the mean age for TKA is 67.4 years ± 9.4, with nonagenarians representing <1% of TKA. However, some hav...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expan...

Commercial Payors More Likely to Reimburse Unlisted Hip Arthroscopy Procedures Compared With Managed Care but With Similar Overall Dollar Amount

Purpose To compare the reimbursement practices of public managed care (MC) insurance versus private commercial insurance (COM) for hip arthroscopy using the current procedural terminology (CPT) code 29999. Methods The CPT codes and corresponding reimbursements of hip arthroscopie...

Preoperative Risk Factors for Opioid Use Predict Self‐Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction

Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients un...

Prepregnancy Obesity Versus Excessive Gestational Weight Gain: A Comparative Evaluation of Adverse Outcomes

Background/Objectives: Obesity and excessive gestational weight gain (EGWG) are known risk factors for adverse outcomes in pregnancy, but the comparative risk is less well defined and increasingly relevant in an era of increasing use of weight loss medications. We aimed to determ...

Deep Learning Applied to 12-Lead ECGs for Detection of Structural, Metabolic and Systemic Disease

The 12-lead electrocardiogram (ECG) is inexpensive, noninvasive, and widely available, but conventional interpretation may not capture subtle signals related to cardiac structure, systemic physiology, and future risk. This review examines the use of deep learning–enabled ECG anal...

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms t...

Resection Margin Status, Recurrence Pattern, and Salvageability After Resection for Colorectal Liver Metastases

Abstract Background The prognostic significance of margin status after colorectal liver metastases (CRLM) resection remains debated in the era of effective systemic therapy. This study examined the prognostic meaning of microscopically positive (R1) margins, focusing on recurrenc...